KEGG   PATHWAY: glc03070
Entry
glc03070                    Pathway                                
Name
Bacterial secretion system - Glaciimonas sp. PAMC28666
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
glc03070  Bacterial secretion system
glc03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Glaciimonas sp. PAMC28666 [GN:glc]
Gene
JQN73_07245  TolC family protein [KO:K12340]
JQN73_08040  TolC family outer membrane protein [KO:K12340]
JQN73_13550  HlyD family type I secretion periplasmic adaptor subunit [KO:K11003]
JQN73_13545  peptidase domain-containing ABC transporter [KO:K11004]
JQN73_18920  EscF/YscF/HrpA family type III secretion system needle major subunit [KO:K03221]
JQN73_18825  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
JQN73_18850  FliM/FliN family flagellar motor switch protein [KO:K03225]
JQN73_16035  gspD; type II secretion system secretin GspD [KO:K02453]
JQN73_20215  gspD; type II secretion system secretin GspD [KO:K02453]
JQN73_21315  secretin [KO:K02453]
JQN73_16050  hypothetical protein [KO:K02452]
JQN73_20200  hypothetical protein [KO:K02452]
JQN73_16045  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
JQN73_20205  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
JQN73_21345  type II secretion system F family protein [KO:K02455]
JQN73_15995  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
JQN73_20255  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
JQN73_21305  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02456]
JQN73_21310  type II secretion system protein [KO:K02456]
JQN73_21355  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
JQN73_16000  GspH/FimT family pseudopilin [KO:K02457]
JQN73_20250  GspH/FimT family pseudopilin [KO:K02457]
JQN73_16005  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
JQN73_20245  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
JQN73_16010  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
JQN73_20240  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
JQN73_16015  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
JQN73_20235  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
JQN73_16020  general secretion pathway protein GspL [KO:K02461]
JQN73_20230  general secretion pathway protein GspL [KO:K02461]
JQN73_16025  type II secretion system protein M [KO:K02462]
JQN73_20225  type II secretion system protein M [KO:K02462]
JQN73_16040  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
JQN73_18650  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
JQN73_20210  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
JQN73_21340  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
JQN73_12120  secD; protein translocase subunit SecD [KO:K03072]
JQN73_12125  secF; protein translocase subunit SecF [KO:K03074]
JQN73_09850  secE; preprotein translocase subunit SecE [KO:K03073]
JQN73_01970  secG; preprotein translocase subunit SecG [KO:K03075]
JQN73_10025  secY; preprotein translocase subunit SecY [KO:K03076]
JQN73_12115  yajC; preprotein translocase subunit YajC [KO:K03210]
JQN73_08390  yidC; membrane protein insertase YidC [KO:K03217]
JQN73_06530  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
JQN73_05890  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
JQN73_07125  secB; protein-export chaperone SecB [KO:K03071]
JQN73_10640  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
JQN73_06130  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
JQN73_06125  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
JQN73_06120  tatC; twin-arginine translocase subunit TatC [KO:K03118]
JQN73_06345  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
JQN73_02180  Hcp family type VI secretion system effector [KO:K11903]
JQN73_02115  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
JQN73_02135  type VI secretion protein VasK [KO:K11891]
JQN73_02170  DotU family type IV/VI secretion system protein [KO:K11892]
JQN73_20340  DotU family type IV/VI secretion system protein [KO:K11892]
JQN73_02185  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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