Entry
Name
Bacterial secretion system - Geobacter sulfurreducens PCA
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Geobacter sulfurreducens PCA [GN:
gsu ]
Gene
GSU0950 efflux pump, RND family, outer membrane protein [KO:K12340 ]
GSU1482 efflux pump, RND family, outer membrane protein [KO:K12340 ]
GSU1609 efflux pump, RND family, outer membrane protein [KO:K12340 ]
GSU1778 pulQ; type II secretion system secretin lipoprotein PulQ [KO:K02453 ]
GSU0329 gspD; type II secretion system lipoprotein GspD, putative [KO:K02453 ]
GSU0330 gspC; type II secretion system protein GspC, putative serine protease [KO:K02452 ]
GSU0327 gspF; type II secretion system inner membrane protein GspF [KO:K02455 ]
GSU1777 pulG; type II secretion system pseudopilin PulG [KO:K02456 ]
GSU0326 gspG; type II secretion system major pseudopilin GspG [KO:K02456 ]
GSU1776 oxpG; type II secretion system pseudopilin OxpG [KO:K02456 ]
GSU0325 gspH; type II secretion system minor pseudopilin GspH [KO:K02457 ]
GSU0324 gspI; type II secretion system minor pseudopilin GspI [KO:K02458 ]
GSU0323 gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459 ]
GSU0322 gspK; type II secretion system minor pseudopilin GspK [KO:K02460 ]
GSU0321 gspL; type II secretion system protein GspL, putative [KO:K02461 ]
GSU0320 gspM; type II secretion system protein GspM, putative [KO:K02462 ]
GSU1132 ftsY; signal recognition particle GTPase FtsY [KO:K03110 ]
GSU0022 tatB; twin-arginine translocation pathway protein TatB [KO:K03116 ]
GSU3190 tatA; twin-arginine translocation pathway protein, TatA/TatE family [KO:K03116 ]
GSU0781 fdnT; twin-arginine translocation pathway protein, TatA/TatE family [KO:K03116 ]
GSU0787 hybT; twin-arginine translocation pathway protein, TatA/TatE family [KO:K03116 ]
GSU1486 tatC; twin-arginine translocation pathway protein TatC [KO:K03118 ]
GSU3177 tssI; type VI secretion system needle syringe protein TssI [KO:K11904 ]
GSU3174 tssD; type VI secretion system needle tube protein TssD [KO:K11903 ]
GSU3166 tssM; type VI secretion system ATPase and inner membrane protein TssM [KO:K11891 ]
GSU3165 tssL; type VI secretion system inner membrane protein TssL [KO:K11892 ]
GSU0433 tssH; type VI secretion system ATPase TssH, putative chaperone [KO:K11907 ]
Compound
Reference
Authors
Kim JF.
Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
Journal
Reference
Authors
Plano GV, Day JB, Ferracci F.
Title
Type III export: new uses for an old pathway.
Journal
Reference
Authors
Gauthier A, Finlay BB.
Title
Bacterial pathogenesis: the answer to virulence is in the pore.
Journal
Reference
Authors
Burns DL.
Title
Biochemistry of type IV secretion.
Journal
Reference
Authors
Christie PJ, Vogel JP.
Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
Journal
Reference
Authors
Christie PJ.
Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
Journal
Reference
Authors
Nunn D.
Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
Journal
Reference
Authors
Sandkvist M.
Title
Biology of type II secretion.
Journal
Reference
Authors
Sandkvist M.
Title
Type II secretion and pathogenesis.
Journal
Reference
Authors
Delepelaire P
Title
Type I secretion in gram-negative bacteria.
Journal
Reference
Authors
Hazes B, Frost L
Title
Towards a systems biology approach to study type II/IV secretion systems.
Journal
Reference
Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
Title
Type II secretion: from structure to function.
Journal
Reference
Authors
Filloux A
Title
The underlying mechanisms of type II protein secretion.
Journal
Reference
Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Journal
Reference
Authors
Ghosh P
Title
Process of protein transport by the type III secretion system.
Journal
Reference
Authors
Cornelis GR
Title
The Yersinia Ysc-Yop 'type III' weaponry.
Journal
Reference
Authors
Baron C
Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
Journal
Reference
Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
Journal
Reference
Authors
Christie PJ, Cascales E
Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
Journal
Reference
Authors
Christie PJ
Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
Journal
Reference
Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
Title
Type V protein secretion pathway: the autotransporter story.
Journal
Reference
Authors
Henderson IR, Navarro-Garcia F, Nataro JP
Title
The great escape: structure and function of the autotransporter proteins.
Journal
Reference
Authors
Filloux A, Hachani A, Bleves S
Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
Journal
Reference
Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
Journal
Reference
Authors
Kulasekara HD, Miller SI
Title
Threonine phosphorylation times bacterial secretion.
Journal
Reference
Authors
Driessen AJ, Nouwen N
Title
Protein translocation across the bacterial cytoplasmic membrane.
Journal
Reference
Authors
Pool MR
Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
Journal
Reference
Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal
Reference
Authors
Nakatogawa H, Murakami A, Ito K
Title
Control of SecA and SecM translation by protein secretion.
Journal
KO pathway
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