KEGG   PATHWAY: haso02010
Entry
haso02010                   Pathway                                
Name
ABC transporters - Halomonas sp. 'Soap Lake #7'
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
haso02010  ABC transporters
haso02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Halomonas sp. 'Soap Lake #7' [GN:haso]
Gene
B2G49_04015  thiosulfate transporter subunit [KO:K02048]
B2G49_04010  sulfate ABC transporter permease subunit CysT [KO:K02046]
B2G49_04005  sulfate ABC transporter permease subunit CysW [KO:K02047]
B2G49_04000  sulfate ABC transporter ATP-binding protein [KO:K02045] [EC:7.3.2.3]
B2G49_04790  sulfate transporter [KO:K05772]
B2G49_04800  ABC transporter permease [KO:K05773]
B2G49_04795  ABC transporter ATP-binding protein [KO:K06857] [EC:7.3.2.6]
B2G49_14995  bicarbonate-binding protein [KO:K15576]
B2G49_15000  nitrate ABC transporter, permease protein [KO:K15577]
B2G49_15005  nitrate ABC transporter ATP-binding protein [KO:K15578] [EC:7.3.2.4]
B2G49_07555  ABC transporter substrate-binding protein [KO:K15598]
B2G49_00480  molybdate ABC transporter substrate-binding protein [KO:K02020]
B2G49_00485  molybdenum ABC transporter permease subunit [KO:K02018]
B2G49_00490  ABC transporter [KO:K02017] [EC:7.3.2.5]
B2G49_20475  ABC transporter substrate-binding protein [KO:K02012]
B2G49_21570  Fe(3+) ABC transporter substrate-binding protein [KO:K02012]
B2G49_14765  ABC transporter substrate-binding protein [KO:K02012]
B2G49_15995  putative 2-aminoethylphosphonate ABC transporter substrate-binding protein [KO:K02012]
B2G49_20470  ABC transporter permease [KO:K02011]
B2G49_21580  iron ABC transporter permease [KO:K02011]
B2G49_14770  ABC transporter permease [KO:K02011]
B2G49_15985  phosphonate ABC transporter permease [KO:K02011]
B2G49_20480  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
B2G49_21575  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
B2G49_14775  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
B2G49_15990  phosphonate ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
B2G49_03885  spermidine/putrescine ABC transporter substrate-binding protein PotF [KO:K11073]
B2G49_03900  putrescine ABC transporter permease PotI [KO:K11074]
B2G49_03895  putrescine ABC transporter permease PotH [KO:K11075]
B2G49_03890  polyamine ABC transporter ATP-binding protein [KO:K11076] [EC:7.6.2.16]
B2G49_07745  ABC transporter substrate-binding protein [KO:K05845]
B2G49_07730  osmoprotectant uptake system permease [KO:K05846]
B2G49_07740  ABC transporter permease [KO:K05846]
B2G49_07735  ABC transporter [KO:K05847] [EC:7.6.2.9]
B2G49_09585  maltose ABC transporter substrate-binding protein MalE [KO:K10108]
B2G49_09590  maltose ABC transporter permease MalF [KO:K10109]
B2G49_09595  malG; maltose transporter permease [KO:K10110]
B2G49_03040  ABC transporter [KO:K10111] [EC:7.5.2.-]
B2G49_09600  ABC transporter [KO:K10111] [EC:7.5.2.-]
B2G49_09640  ABC transporter [KO:K10111] [EC:7.5.2.-]
B2G49_03260  sugar ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
B2G49_03025  sugar ABC transporter substrate-binding protein [KO:K10227]
B2G49_03030  sugar ABC transporter permease [KO:K10228]
B2G49_03035  sugar ABC transporter permease [KO:K10229]
B2G49_01945  ABC transporter substrate-binding protein [KO:K10236]
B2G49_09620  ABC transporter substrate-binding protein [KO:K10236]
B2G49_09625  ABC transporter permease [KO:K10237]
B2G49_09630  sugar ABC transporter permease [KO:K10238]
B2G49_05155  toluene tolerance protein [KO:K07323]
B2G49_05150  outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
B2G49_07700  ABC transporter permease [KO:K02067]
B2G49_05145  ABC transporter permease [KO:K02066]
B2G49_07690  ABC transporter permease [KO:K02066]
B2G49_05160  anti-anti-sigma factor [KO:K07122]
B2G49_05140  phospholipid ABC transporter ATP-binding protein MlaF [KO:K02065]
B2G49_07695  ABC transporter ATP-binding protein [KO:K02065]
B2G49_03245  sugar ABC transporter substrate-binding protein [KO:K17315]
B2G49_03250  ABC transporter permease [KO:K17316]
B2G49_03255  sugar ABC transporter permease [KO:K17317]
B2G49_17870  ribose ABC transporter substrate-binding protein [KO:K10439]
B2G49_17875  ribose ABC transporter permease [KO:K10440]
B2G49_17880  ABC transporter ATP-binding protein [KO:K10562] [EC:7.5.2.-]
B2G49_06225  ABC transporter substrate-binding protein [KO:K17321]
B2G49_06240  ABC transporter permease [KO:K17322]
B2G49_06235  sugar ABC transporter permease [KO:K17323]
B2G49_06250  ABC transporter ATP-binding protein [KO:K17324]
B2G49_06245  ABC transporter ATP-binding protein [KO:K17325]
B2G49_20540  sn-glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
B2G49_14690  ABC transporter substrate-binding protein [KO:K05813]
B2G49_20535  glycerol-3-phosphate transporter permease [KO:K05814]
B2G49_14695  ABC transporter permease [KO:K05814]
B2G49_20530  glycerol-3-phosphate transporter [KO:K05815]
B2G49_14700  ABC transporter permease [KO:K05815]
B2G49_20525  sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K05816] [EC:7.6.2.10]
B2G49_14685  ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
B2G49_06730  ABC transporter substrate-binding protein [KO:K02040]
B2G49_10175  phosphonate ABC transporter substrate-binding protein [KO:K02040]
B2G49_18530  phosphate ABC transporter substrate-binding protein [KO:K02040]
B2G49_10170  phosphate ABC transporter permease subunit PstC [KO:K02037]
B2G49_18535  ABC transporter permease [KO:K02037]
B2G49_10165  phosphate ABC transporter, permease protein PstA [KO:K02038]
B2G49_18540  phosphate ABC transporter, permease protein PstA [KO:K02038]
B2G49_10160  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
B2G49_18545  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
B2G49_20645  phosphonate ABC transporter substrate-binding protein [KO:K02044]
B2G49_17750  phosphonate ABC transporter substrate-binding protein [KO:K02044]
B2G49_20655  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
B2G49_20660  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
B2G49_17760  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
B2G49_17765  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
B2G49_20650  phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
B2G49_17755  phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
B2G49_18945  amino acid ABC transporter substrate-binding protein [KO:K10036]
B2G49_18940  nickel transporter [KO:K10037]
B2G49_18935  peptide ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
B2G49_17710  amino acid ABC transporter substrate-binding protein [KO:K09969]
B2G49_17720  amino acid ABC transporter substrate-binding protein [KO:K09969]
B2G49_17725  amino acid ABC transporter permease [KO:K09970]
B2G49_17730  amino acid ABC transporter permease [KO:K09971]
B2G49_17735  ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
B2G49_21065  amino acid ABC transporter substrate-binding protein [KO:K16961]
B2G49_21070  ABC transporter permease [KO:K16962]
B2G49_21075  amino acid ABC transporter ATP-binding protein [KO:K16963]
B2G49_11350  nickel transporter [KO:K10022]
B2G49_11355  nickel transporter [KO:K10022]
B2G49_11360  nickel transporter [KO:K10022]
B2G49_11345  amino acid ABC transporter permease [KO:K10023]
B2G49_11340  ABC transporter [KO:K10024]
B2G49_11335  histidine/lysine/arginine/ornithine ABC transporter ATP-binding protein [KO:K10025] [EC:7.4.2.1]
B2G49_19850  amino acid ABC transporter substrate-binding protein [KO:K01999]
B2G49_05810  ABC transporter permease [KO:K01999]
B2G49_10015  ABC transporter permease [KO:K01999]
B2G49_10500  ABC transporter substrate-binding protein [KO:K01999]
B2G49_12225  transcriptional regulator [KO:K01999]
B2G49_18125  ABC transporter permease [KO:K01999]
B2G49_19860  branched-chain amino acid ABC transporter permease [KO:K01997]
B2G49_05815  branched-chain amino acid ABC transporter permease [KO:K01997]
B2G49_10505  branched-chain amino acid ABC transporter permease [KO:K01997]
B2G49_18120  branched-chain amino acid ABC transporter permease [KO:K01997]
B2G49_19855  branched-chain amino acid ABC transporter permease [KO:K01998]
B2G49_05820  branched-chain amino acid ABC transporter permease [KO:K01998]
B2G49_10510  branched-chain amino acid ABC transporter permease [KO:K01998]
B2G49_18115  branched-chain amino acid ABC transporter permease [KO:K01998]
B2G49_19870  ABC transporter ATP-binding protein [KO:K01995]
B2G49_05800  ABC transporter ATP-binding protein [KO:K01995]
B2G49_10515  ABC transporter ATP-binding protein [KO:K01995]
B2G49_18110  ABC transporter ATP-binding protein [KO:K01995]
B2G49_19865  ABC transporter ATP-binding protein [KO:K01996]
B2G49_05805  ABC transporter ATP-binding protein [KO:K01996]
B2G49_10520  ABC transporter ATP-binding protein [KO:K01996]
B2G49_18105  ABC transporter ATP-binding protein [KO:K01996]
B2G49_08225  hypothetical protein [KO:K02073]
B2G49_08220  methionine ABC transporter permease [KO:K02072]
B2G49_08215  metN; DL-methionine transporter ATP-binding subunit [KO:K02071]
B2G49_17545  urea ABC transporter substrate-binding protein [KO:K11959]
B2G49_17540  urea ABC transporter permease subunit UrtB [KO:K11960]
B2G49_17535  urea ABC transporter permease subunit UrtC [KO:K11961]
B2G49_17530  urea ABC transporter ATP-binding protein UrtD [KO:K11962]
B2G49_17525  urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
B2G49_07625  hypothetical protein [KO:K13893]
B2G49_07630  microcin ABC transporter permease [KO:K13894]
B2G49_07635  ABC transporter permease [KO:K13895]
B2G49_07640  microcin ABC transporter ATP-binding protein [KO:K13896]
B2G49_12295  ABC transporter substrate-binding protein [KO:K25286]
B2G49_17370  ABC transporter substrate-binding protein [KO:K25286]
B2G49_17375  iron ABC transporter permease [KO:K23186]
B2G49_12290  ABC transporter permease [KO:K23186]
B2G49_12285  ABC transporter permease [KO:K23187]
B2G49_17380  hypothetical protein [KO:K23187]
B2G49_12280  ABC transporter [KO:K23188] [EC:7.2.2.17 7.2.2.-]
B2G49_01355  hypothetical protein [KO:K23227]
B2G49_01495  ABC transporter substrate-binding protein [KO:K23227]
B2G49_01515  hypothetical protein [KO:K23227]
B2G49_01540  hypothetical protein [KO:K23227]
B2G49_17250  ABC transporter substrate-binding protein [KO:K23227]
B2G49_17840  ABC transporter substrate-binding protein [KO:K23227]
B2G49_01395  Fe3+-hydroxamate ABC transporter permease FhuB [KO:K23228]
B2G49_01285  iron-hydroxamate transporter ATP-binding subunit [KO:K10829] [EC:7.2.2.16]
B2G49_06470  ABC transporter [KO:K11603] [EC:7.2.2.5]
B2G49_06475  hypothetical protein [KO:K19976]
B2G49_20750  metal-binding protein ZinT [KO:K09815]
B2G49_06465  ABC transporter substrate-binding protein [KO:K11604]
B2G49_04170  chain-length determining protein [KO:K10107]
B2G49_04165  ABC transporter permease [KO:K09688]
B2G49_04210  polysaccharide/polyol phosphate ABC transporter ATP-binding protein [KO:K09689] [EC:7.6.2.12]
B2G49_05380  ABC transporter permease [KO:K09808]
B2G49_05385  lipoprotein ABC transporter ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
B2G49_12815  heme exporter protein CcmD [KO:K02196]
B2G49_12820  heme ABC transporter permease [KO:K02195]
B2G49_12825  heme exporter protein CcmB [KO:K02194]
B2G49_12830  heme ABC transporter ATP-binding protein CcmA [KO:K02193] [EC:7.6.2.5]
B2G49_13670  LPS export ABC transporter permease LptF [KO:K07091]
B2G49_13665  LPS export ABC transporter permease LptG [KO:K11720]
B2G49_05115  LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
B2G49_14055  cell division protein FtsX [KO:K09811]
B2G49_14060  cell division ATP-binding protein FtsE [KO:K09812]
B2G49_01445  ABC transporter [KO:K14698] [EC:7.-.-.-]
B2G49_17430  ABC transporter ATP-binding protein [KO:K14698] [EC:7.-.-.-]
B2G49_01450  ABC transporter [KO:K14699] [EC:7.-.-.-]
B2G49_17435  ABC transporter ATP-binding protein [KO:K14699] [EC:7.-.-.-]
B2G49_05400  lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
B2G49_01155  ABC transporter [KO:K11004]
B2G49_02560  multidrug ABC transporter ATP-binding protein [KO:K18893]
B2G49_00035  type I secretion system permease/ATPase [KO:K12541]
B2G49_11010  type I secretion system permease/ATPase [KO:K12541]
B2G49_15815  type I secretion system permease/ATPase [KO:K12536]
B2G49_07985  thiol reductant ABC exporter subunit CydC [KO:K16012]
B2G49_07990  thiol reductant ABC exporter subunit CydD [KO:K16013]
B2G49_01405  multidrug ABC transporter permease/ATP-binding protein [KO:K06159]
B2G49_01380  peptide ABC transporter [KO:K06160]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
LinkDB

DBGET integrated database retrieval system