KEGG   PATHWAY: hvi00980
Entry
hvi00980                    Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Homalodisca vitripennis (glassy-winged sharpshooter)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
hvi00980  Metabolism of xenobiotics by cytochrome P450
hvi00980

Organism
Homalodisca vitripennis (glassy-winged sharpshooter) [GN:hvi]
Gene
124357962  glutathione S-transferase D5-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124368352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124358654  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124369242  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124371224  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361800  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361941  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124361943  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361944  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361945  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124373887  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124363353  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124353840  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
124366181  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124355869  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
124356706  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367172  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124367503  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
124367723  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367830  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367831  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367832  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367833  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367834  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124359197  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359713  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359714  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124372366  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373429  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373430  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124374570  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124355503  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366172  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366173  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366369  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366374  glutathione S-transferase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366381  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366382  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366747  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366896  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367539  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367541  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367542  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367544  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124355024  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase-like [KO:K00078] [EC:1.3.1.20 1.1.1.179]
124358221  carbonyl reductase [NADPH] 3-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
124356882  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
124356884  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
124356684  carbonyl reductase [NADPH] 1-like [KO:K00084] [EC:1.1.1.184]
124356998  carbonyl reductase [NADPH] 3-like isoform X1 [KO:K00084] [EC:1.1.1.184]
124369783  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124369824  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124359966  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124370565  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372159  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372952  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124373602  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124362431  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124374548  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124352719  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124352720  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124352721  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353662  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353979  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354323  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354733  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354735  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354736  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354942  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354943  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354945  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354947  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354948  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354958  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354959  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354963  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365848  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124365857  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365858  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355454  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355520  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355521  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124365982  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124366202  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355879  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355885  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356360  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356361  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356362  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354901  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
124359338  alcohol dehydrogenase class-3 chain L-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
124359339  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
PMID:12487150
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
PMID:10725110
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
PMID:10570027
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
PMID:10490505
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
PMID:15319346
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
PMID:15987776
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
PMID:15298956
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   
LinkDB

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