KEGG   PATHWAY: ksk02010
Entry
ksk02010                    Pathway                                
Name
ABC transporters - Kitasatospora setae
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
ksk02010  ABC transporters
ksk02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Kitasatospora setae [GN:ksk]
Gene
KSE_13160  tauA; putative taurine ABC transporter substrate-binding protein [KO:K15551]
KSE_13170  tauC; putative taurine ABC transporter permease protein [KO:K15552]
KSE_13150  tauB; putative taurine ABC transporter ATP-binding protein [KO:K10831] [EC:7.6.2.7]
KSE_45060  ssuA1; putative aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
KSE_62880  putative aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
KSE_62910  ssuA2; putative aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
KSE_06010  putative ABC transporter substrate-binding protein [KO:K15553]
KSE_19830  ssuA3; putative aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
KSE_33150  putative ABC transporter substrate-binding protein [KO:K15553]
KSE_45070  ssuC1; putative aliphatic sulfonate ABC transporter permease protein [KO:K15554]
KSE_62890  ssuC2; putative aliphatic sulfonate ABC transporter permease protein [KO:K15554]
KSE_19810  ssuC3; putative aliphatic sulfonate ABC transporter permease protein [KO:K15554]
KSE_06000  putative ABC transporter permease protein [KO:K15554]
KSE_33160  putative ABC transporter permease protein [KO:K15554]
KSE_62900  ssuB2; putative aliphatic sulfonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
KSE_45080  ssuB1; putative aliphatic sulfonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
KSE_33170  putative ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
KSE_19820  ssuB3; putative aliphatic sulfonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
KSE_05990  putative ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
KSE_62350  modA; putative molybdate ABC transporter substrate-binding protein [KO:K02020]
KSE_75200  hypothetical protein [KO:K02020]
KSE_62340  modB; putative molybdate ABC transporter permease protein [KO:K02018]
KSE_62330  modC; putative molybdate ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
KSE_61920  putative osmoprotectant ABC transporter substrate-binding protein [KO:K05845]
KSE_61930  putative osmoprotectant ABC transporter permease protein [KO:K05846]
KSE_61940  putative osmoprotectant ABC transporter permease protein [KO:K05846]
KSE_61950  putative osmoprotectant ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
KSE_34400  msiK; putative multiple sugar ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
KSE_17240  malE; putative maltose-binding protein [KO:K15770]
KSE_17230  malF; putative maltose permease [KO:K15771]
KSE_17220  malG; putative maltose permease [KO:K15772]
KSE_73860  putative sugar ABC transporter substrate-binding protein [KO:K10117]
KSE_73850  putative sugar ABC transporter permease protein [KO:K10118]
KSE_73840  putative sugar ABC transporter permease protein [KO:K10119]
KSE_06260  araN; putative L-arabinose ABC transporter substrate-binding protein [KO:K10188]
KSE_06250  araP; putative L-arabinose ABC transporter permease protein [KO:K10189]
KSE_06240  araQ; putative L-arabinose ABC transporter permease protein [KO:K10190]
KSE_53910  aglE2; putative alpha-glucoside ABC transporter substrate-binding protein [KO:K10232]
KSE_53920  aglF2; putative alpha-glucoside ABC transporter permease protein [KO:K10233]
KSE_53930  aglG2; putative alpha-glucoside ABC transporter permease protein [KO:K10234]
KSE_26410  ngcE; putative chitobiose ABC transporter substrate-binding protein [KO:K10200]
KSE_26400  ngcF; putative chitobiose ABC transporter permease protein [KO:K10201]
KSE_26390  ngcG; putative chitobiose ABC transporter permease protein [KO:K10202]
KSE_02330  cebE3; putative cellobiose ABC transporter substrate-binding protein [KO:K10240]
KSE_26970  cebE1; putative cellobiose ABC transporter substrate-binding protein [KO:K10240]
KSE_57730  cebE2; putative cellobiose ABC transporter substrate-binding protein [KO:K10240]
KSE_02340  cebF3; putative cellobiose ABC transporter permease protein [KO:K10241]
KSE_26980  cebF1; putative cellobiose ABC transporter permease protein [KO:K10241]
KSE_57740  cebF2; putative cellobiose ABC transporter permease protein [KO:K10241]
KSE_02350  cebG3; putative cellobiose ABC transporter permease protein [KO:K10242]
KSE_26990  cebG1; putative cellobiose ABC transporter permease protein [KO:K10242]
KSE_57750  cebG2; putative cellobiose ABC transporter permease protein [KO:K10242]
KSE_01630  putative sugar ABC transporter solute-binding protein [KO:K17329]
KSE_49380  dasA2; putative chitobiose ABC transporter solute-binding protein [KO:K17329]
KSE_49390  dasA1; putative chitobiose ABC transporter solute-binding protein [KO:K17329]
KSE_19000  putative sugar ABC transporter solute-binding protein [KO:K17329]
KSE_19010  putative sugar ABC transporter permease protein [KO:K17330]
KSE_01620  putative sugar ABC transporter permease protein [KO:K17330]
KSE_49370  dasB; putative chitobiose ABC transporter permease protein [KO:K17330]
KSE_49360  dasC; putative chitobiose ABC transporter permease protein [KO:K17331]
KSE_19020  putative sugar ABC transporter permease protein [KO:K17331]
KSE_01610  putative sugar ABC transporter permease protein [KO:K17331]
KSE_59560  bxlD; putative beta-xyloside ABC transporter substrate-binding protein [KO:K17326]
KSE_59570  bxlC; putative beta-xyloside ABC transporter permease protein [KO:K17327]
KSE_59580  bxlB; putative beta-xyloside ABC transporter permease protein [KO:K17328]
KSE_30320  putative ABC transporter substrate-binding protein [KO:K07335]
KSE_30300  putative ABC transporter permease protein [KO:K23535]
KSE_30290  putative ABC transporter permease protein [KO:K23536]
KSE_30310  putative ABC transporter ATP-binding protein [KO:K23537]
KSE_45340  putative ABC transporter substrate-binding protein [KO:K17315]
KSE_13630  putative sugar ABC transporter substrate-binding protein [KO:K10439]
KSE_13650  putative sugar ABC transporter permease protein [KO:K10440]
KSE_13640  putative sugar ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
KSE_74110  putative sugar ABC transporter substrate-binding protein [KO:K23508]
KSE_74140  putative sugar ABC transporter permease protein [KO:K23509]
KSE_74130  putative sugar ABC transporter permease protein [KO:K23509]
KSE_74120  putative sugar ABC transporter ATP-binding protein [KO:K10820] [EC:7.5.2.9]
KSE_55000  xylF1; putative xylose ABC transporter substrate-binding protein [KO:K10543]
KSE_61560  putative ABC transporter substrate-binding protein [KO:K10543]
KSE_73890  xylF2; putative xylose ABC transporter substrate-binding protein [KO:K10543]
KSE_55020  xylH1; putative xylose ABC transporter permease protein [KO:K10544]
KSE_73910  xylH2; putative xylose ABC transporter permease protein [KO:K10544]
KSE_73900  xylG2; putative xylose ABC transporter ATP-binding protein [KO:K10545] [EC:7.5.2.10]
KSE_55010  xylG1; putative xylose ABC transporter ATP-binding protein [KO:K10545] [EC:7.5.2.10]
KSE_43400  pstS; putative phosphate ABC transporter substrate-binding protein [KO:K02040]
KSE_10390  putative phosphate ABC transporter substrate-binding protein [KO:K02040]
KSE_10410  putative phosphate ABC transporter permease protein [KO:K02037]
KSE_43410  pstC; putative phosphate ABC transporter permease protein [KO:K02037]
KSE_10400  putative phosphate ABC transporter permease protein [KO:K02038]
KSE_43420  pstA; putative phosphate ABC transporter permease protein [KO:K02038]
KSE_10370  putative phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
KSE_43430  pstB; putative phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
KSE_17430  gluB1; putative glutamate ABC transporter substrate-binding protein [KO:K10005]
KSE_53650  gluB2; putative glutamate ABC transporter substrate-binding protein [KO:K10005]
KSE_66290  putative ABC transporter substrate-binding protein [KO:K10005]
KSE_17420  gluC1; putative glutamate ABC transporter permease protein [KO:K10006]
KSE_53640  gluC2; putative glutamate ABC transporter permease protein [KO:K10006]
KSE_17410  gluD1; putative glutamate ABC transporter permease protein [KO:K10007]
KSE_53630  gluD2; putative glutamate ABC transporter permease protein [KO:K10007]
KSE_17440  gluA1; putative glutamate ABC transporter ATP-binding protein [KO:K10008] [EC:7.4.2.1]
KSE_53660  gluA2; putative glutamate ABC transporter ATP-binding protein [KO:K10008] [EC:7.4.2.1]
KSE_20280  putative branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
KSE_44830  hypothetical protein [KO:K01999]
KSE_20290  livH; putative branched-chain amino acid ABC transporter permease protein [KO:K01997]
KSE_20300  livM; putative branched-chain amino acid ABC transporter permease protein [KO:K01998]
KSE_20310  livG; putative branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
KSE_20320  livF; putative branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
KSE_14800  metQ; putative methionine ABC transporter substrate-binding protein [KO:K02073]
KSE_14810  metI; putative methionine ABC transporter permease protein [KO:K02072]
KSE_14820  metN; putative methionine ABC transporter ATP-binding protein [KO:K02071]
KSE_06090  amiC; putative acetamidase regulator [KO:K11959]
KSE_48150  putative peptide ABC transporter substrate-binding protein [KO:K15580]
KSE_48200  putative peptide ABC transporter substrate-binding protein [KO:K15580]
KSE_48160  putative peptide ABC transporter permease protein [KO:K15581]
KSE_48210  putative peptide ABC transporter permease protein [KO:K15581]
KSE_48170  putative peptide ABC transporter permease protein [KO:K15582]
KSE_48220  putative peptide ABC transporter permease protein [KO:K15582]
KSE_48230  putative peptide ABC transporter ATP-binding protein [KO:K15583]
KSE_48180  putative peptide ABC transporter ATP-binding protein [KO:K15583]
KSE_48240  putative peptide ABC transporter ATP-binding protein [KO:K10823]
KSE_48190  putative peptide ABC transporter ATP-binding protein [KO:K10823]
KSE_06380  putative peptide ABC transporter substrate-binding protein [KO:K13889]
KSE_48300  putative ABC transporter substrate-binding protein [KO:K13889]
KSE_06370  putative peptide ABC transporter permease protein [KO:K13890]
KSE_06360  putative peptide ABC transporter permease protein [KO:K13891]
KSE_06350  putative peptide ABC transporter ATP-binding protein [KO:K13892]
KSE_35420  putative iron-siderophore ABC transporter substrate-binding protein [KO:K25287]
KSE_12650  putative iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
KSE_12620  fepD1; putative iron-siderophore ABC transporter permease protein [KO:K23186]
KSE_35410  fepD2; putative iron-siderophore ABC transporter permease protein [KO:K23186]
KSE_12630  fepG1; putative iron-siderophore ABC transporter permease protein [KO:K23187]
KSE_35400  fepG2; putative iron-siderophore ABC transporter permease protein [KO:K23187]
KSE_12640  fepC1; putative iron-siderophore ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
KSE_35390  fepC2; putative iron-siderophore ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
KSE_25400  putative metal ABC transporter substrate-binding protein [KO:K09815]
KSE_25420  putative metal ABC transporter permease protein [KO:K09816]
KSE_25410  putative metal ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
KSE_26350  putative BioY protein [KO:K03523]
KSE_24240  putative ABC transporter permease protein [KO:K16785]
KSE_17650  rfbA1; putative polysaccharide ABC transporter permease protein [KO:K09692]
KSE_17640  rfbB1; putative polysaccharide ABC transporter ATP-binding protein [KO:K09693] [EC:7.5.2.4]
KSE_66860  putative membrane protein [KO:K09813]
KSE_11660  putative membrane protein [KO:K09813]
KSE_11650  putative ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
KSE_66850  putative ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
KSE_23540  putative multidrug ABC transporter permease protein [KO:K18233]
KSE_23530  putative multidrug ABC transporter ATP-binding protein [KO:K18232]
KSE_28870  ftsX; putative cell division protein FtsX [KO:K09811]
KSE_28880  ftsE; putative cell division ATP-binding protein [KO:K09812]
KSE_25770  putative multidrug ABC transporter ATP-binding and permease protein [KO:K18887]
KSE_25780  putative multidrug ABC transporter ATP-binding and permease protein [KO:K18888]
KSE_40240  cydCD; putative cysteine ABC transporter ATP-binding and permease protein [KO:K16014]
KSE_10780  putative ABC transporter ATP-binding protein [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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