KEGG   PATHWAY: lmc02010
Entry
lmc02010                    Pathway                                
Name
ABC transporters - Listeria monocytogenes CLIP 80459 (serotype 4b)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
lmc02010  ABC transporters
lmc02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Listeria monocytogenes CLIP 80459 (serotype 4b) [GN:lmc]
Gene
Lm4b_01061  Putative molybdate ABC transporter binding protein [KO:K02020]
Lm4b_01060  Putative molybdenum ABC transporter (permease) [KO:K02018]
Lm4b_01059  Putative ABC transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
Lm4b_00825  Putative spermidine/putrescine-binding protein [KO:K11069]
Lm4b_00824  Putative spermidine/putrescine ABC transporter, permease protein [KO:K11070]
Lm4b_00823  Putative spermidine/putrescine ABC transporter, permease protein [KO:K11071]
Lm4b_00822  Putative spermidine/putrescine ABC transporter, ATP-binding protein [KO:K11072] [EC:7.6.2.11]
Lm4b_01036  gbuC; Putative glycine betaine ABC transporter (glycine betaine-binding protein) [KO:K02002]
Lm4b_01035  gbuB; Putative glycine betaine ABC transporter (permease) [KO:K02001]
Lm4b_01034  gbuA; Putative glycine betaine ABC transporter (ATP-binding protein) [KO:K02000] [EC:7.6.2.9]
Lm4b_01431  Putative glycine betaine/carnitine/choline ABC transporter (membrane protein) [KO:K05845 K05846]
Lm4b_01435  opuCC; Putative glycine betaine/carnitine/choline ABC transporter (osmoprotectant-binding protein) [KO:K05845]
Lm4b_01434  opuCD; Putative betaine/carnitine/choline ABC transporter (membrane protein) [KO:K05846]
Lm4b_01436  opuCB; Putative glycine betaine/carnitine/choline ABC transporter (membrane protein) [KO:K05846]
Lm4b_01430  Putative glycine betaine/carnitine/choline ABC transporter (ATP-binding protein) [KO:K05847] [EC:7.6.2.9]
Lm4b_01437  opuCA; Putative glycine betaine/carnitine/choline ABC transporter (ATP-binding protein) [KO:K05847] [EC:7.6.2.9]
Lm4b_00306  Putative sugar ABC transporter, ATP-binding protein [KO:K10112] [EC:7.5.2.-]
Lm4b_02149  Putative maltose/maltodextrin ABC-transporter (binding protein) [KO:K15770]
Lm4b_00275  Putative maltose/maltodextrin ABC transporter (binding protein) [KO:K15770]
Lm4b_00276  Putative maltose/maltodextrin ABC transport system (permease) [KO:K15771]
Lm4b_02148  Putative maltodextrin ABC-transport system (permease) [KO:K15771]
Lm4b_00277  putative maltose/maltodextrin ABC transport system (permease) [KO:K15772]
Lm4b_02147  Putative maltodextrin ABC-transport system (permease) [KO:K15772]
Lm4b_02019  Putative sugar-binding lipoprotein [KO:K17318]
Lm4b_02021  Putative transport system integral membrane protein [KO:K17319]
Lm4b_02020  Putative ABC transporter, permease protein [KO:K17320]
Lm4b_01397  tcsA; Putative CD4+ T cell-stimulating antigen, lipoprotein [KO:K07335]
Lm4b_01399  Putative ABC transporter (permease protein) [KO:K23535]
Lm4b_01400  Putative sugar ABC transporter, permease protein [KO:K23536]
Lm4b_01398  Putative sugar ABC transporter, ATP-binding protein [KO:K23537]
Lm4b_02468  Putative phosphate ABC transporter (binding protein) [KO:K02040]
Lm4b_02467  Putative phosphate ABC transporter (permease protein) [KO:K02037]
Lm4b_02466  Putative phosphate ABC transporter (permease protein) [KO:K02038]
Lm4b_02464  Putative phosphate ABC transporter (ATP-binding protein) [KO:K02036] [EC:7.3.2.1]
Lm4b_02465  Putative phosphate ABC transporter (ATP-binding protein) [KO:K02036] [EC:7.3.2.1]
Lm4b_00863  Putative Glutamine ABC transporter (binding and transport protein) [KO:K10036 K10037]
Lm4b_00864  Putative amino acid ABC transporter, ATP-binding protein [KO:K10038] [EC:7.4.2.1]
Lm4b_02313  Putative amino acid ABC transporter (binding protein) [KO:K16957]
Lm4b_02312  Putative amino acid ABC-transporter (permease) [KO:K16958]
Lm4b_02311  Putative amino acid ABC transporter (permease) [KO:K16959]
Lm4b_02310  Putative amino acid ABC-transporter, ATP-binding protein [KO:K16960] [EC:7.4.2.1]
Lm4b_02277  arpJ; Putative amino acid ABC transporter, permease protein [KO:K17077 K23059]
Lm4b_02278  Putative amino acid ABC transporter (ATP-binding protein) [KO:K23060] [EC:7.4.2.1]
Lm4b_02386  Conserved lipoprotein (putative ABC transporter binding protein) [KO:K02073]
Lm4b_00313  Putative lipoprotein [KO:K02073]
Lm4b_02387  Putative ABC transporter, permease protein [KO:K02072]
Lm4b_00311  Putative ABC transporter permease protein [KO:K02072]
Lm4b_02388  Putative ABC transporter (ATP-binding protein) [KO:K02071]
Lm4b_00312  Putative ABC transporter (ATP-binding protein) [KO:K02071]
Lm4b_02223  Putative pheromone ABC transporter (binding protein) [KO:K15580]
Lm4b_02222  Putative oligopeptide ABC transporter (permease) [KO:K15581]
Lm4b_02221  Putative oligopeptide ABC transporter (permease) [KO:K15582]
Lm4b_02220  Putative oligopeptide ABC transporter (ATP-binding protein) [KO:K15583]
Lm4b_02219  Putative oligopeptide ABC transporter (ATP-binding protein) [KO:K10823]
Lm4b_01863  mntA; Putative Manganese-binding lipoprotein mntA [KO:K19975]
Lm4b_01864  Putative metal cations ABC transporter (permease protein) [KO:K19976]
Lm4b_01865  Putative metal cations ABC transporter, ATP-binding proteins [KO:K19973] [EC:7.2.2.5]
Lm4b_00153  Putative a probable high-affinity zinc ABC transporter (Zn(II)-binding lipoprotein) [KO:K09815]
Lm4b_01684  Putative ABC transporter/adhesion protein [KO:K09815]
Lm4b_00155  Putative high-affinity zinc ABC transporter (membrane protein) [KO:K09816]
Lm4b_01456  zurM; metal (zinc) transport protein (ABC transporter, permease protein) [KO:K09816]
Lm4b_00154  Putative high-affinity zinc ABC transporter (ATP-binding protein) [KO:K09817] [EC:7.2.2.20]
Lm4b_01457  zurA; metal (zinc) transport protein(ABC transporter, ATP-binding protein) [KO:K09817] [EC:7.2.2.20]
Lm4b_01209  Putative cobalt transport protein CbiN [KO:K02009]
Lm4b_01208  Putative cobalamin biosynthesis protein M [KO:K02007]
Lm4b_01210  cbiQ; Putative cobalt transport protein Q [KO:K02008]
Lm4b_01211  Putative cobalt transport ATP-binding protein CbiO [KO:K02006]
Lm4b_00624  Putative protein involved in biotin metabolism (BioY) [KO:K03523]
Lm4b_02566  Putative cobalt ABC transporter, permease protein [KO:K16785]
Lm4b_02601  Putative Cobalt transport protein [KO:K16785]
Lm4b_02568  Putative ABC transporter (ATP-binding protein) [KO:K16786] [EC:7.-.-.-]
Lm4b_02567  Putative ABC transporter (ATP-binding protein) [KO:K16787] [EC:7.-.-.-]
Lm4b_01007  Putative Streptococcus agalactiae CylB protein [KO:K11051]
Lm4b_01006  Putative antibiotic ABC transporter, ATP-binding protein [KO:K11050]
Lm4b_01090  Putative teichoic acid translocation permease protein TagG [KO:K09692]
Lm4b_01091  Putative teichoic acid translocation ATP-binding protein TagH (ABC transporter) [KO:K09693] [EC:7.5.2.4]
Lm4b_02341  Putative ABC-transporter transmembrane subunit [KO:K09813]
Lm4b_02548  unnamed protein product; Conserved hypothetical protein [KO:K09813]
Lm4b_02342  Putative ABC-transporter ATP binding protein [KO:K09814] [EC:7.6.2.-]
Lm4b_02547  Putative ABC transporter, ATP-binding protein [KO:K09814] [EC:7.6.2.-]
Lm4b_02137  Putative ABC transporter (permease) [KO:K11632]
Lm4b_01760  Putative ABC transporter (permease) [KO:K11632]
Lm4b_01761  Putative ABC transporter (ATP-binding protein) [KO:K11631]
Lm4b_02136  Putative ABC transporter (ATP-binding protein) [KO:K11631]
Lm4b_02475  ftsX; Putative cell-division protein FtsX [KO:K09811]
Lm4b_02476  ftsE; Putative the cell-division ATP-binding protein FtsE [KO:K09812]
Lm4b_02266  Hypothetical protein of unknown function [KO:K16919]
Lm4b_02743  Hypothetical membrane protein [KO:K16919]
Lm4b_02267  Putative ABC transporter (ATP-binding protein) [KO:K16921]
Lm4b_02744  Putative ABC transporter, ATP-binding protein [KO:K16921]
Lm4b_01662  Putative ABC transporter (ATP-binding protein) [KO:K18889]
Lm4b_00112  Putative ABC transporter, ATP-binding protein [KO:K18889]
Lm4b_00111  Putative ABC transporter, ATP-binding protein [KO:K18890]
Lm4b_01661  Putative ABC transporter (ATP-binding protein) [KO:K18890]
Lm4b_02719  Putative ABC transporter (ATP-binding protein) [KO:K18104] [EC:7.6.2.2]
Lm4b_02725  Putative ABC transporter, ATP-binding protein [KO:K18891]
Lm4b_02726  Putative ABC transporter, ATP-binding protein [KO:K18892]
Lm4b_00633  Putative ABC transporter, ATP-binding protein [KO:K18887]
Lm4b_00634  Putative ABC transporter, ATP-binding protein [KO:K18888]
Lm4b_02689  cydD; Putative ABC transporter (ATP-binding protein) required for expression of cytochrome BD [KO:K16012]
Lm4b_02690  cydC; Putative ABC transporter required for expression of cytochrome BD [KO:K16013]
Lm4b_00939  Putative ABC transporter ATP-binding protein (antibiotic resistance) [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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