KEGG   PATHWAY: lmot03060
Entry
lmot03060                   Pathway                                
Name
Protein export - Listeria monocytogenes SLCC2540 (serotype 3b)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lmot03060  Protein export
lmot03060

Other DBs
GO: 0043952 0043953
Organism
Listeria monocytogenes SLCC2540 (serotype 3b) [GN:lmot]
Gene
LMOSLCC2540_2653  secY; preprotein translocase, SecY subunit [KO:K03076]
LMOSLCC2540_0250  secE; preprotein translocase, SecE subunit [KO:K03073]
LMOSLCC2540_2484  secG; preprotein translocase, SecG subunit [KO:K03075]
LMOSLCC2540_1606  secDF; protein-export membrane protein SecDF [KO:K12257]
LMOSLCC2540_1608  yajC; preprotein translocase subunit [KO:K03210]
LMOSLCC2540_2904  oxaA1; membrane protein OxaA 1 precursor [KO:K03217]
LMOSLCC2540_1430  oxaA2; inner membrane protein oxaA2 precursor [KO:K03217]
LMOSLCC2540_0588  secA2; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
LMOSLCC2540_2543  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
LMOSLCC2540_1882  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
LMOSLCC2540_1884  ftsY; cell division ABC transporter, substrate-binding protein [KO:K03110]
LMOSLCC2540_0375  tatA; Sec-independent protein translocase [KO:K03116]
LMOSLCC2540_0374  tatC; Sec-independent protein translocase [KO:K03118]
LMOSLCC2540_1320  sipX; signal peptidase I [KO:K03100] [EC:3.4.21.89]
LMOSLCC2540_1321  sipY; signal peptidase I [KO:K03100] [EC:3.4.21.89]
LMOSLCC2540_1322  sipZ; signal peptidase I [KO:K03100] [EC:3.4.21.89]
LMOSLCC2540_1926  lspA; lipoprotein signal peptidase [KO:K03101] [EC:3.4.23.36]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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