KEGG   PATHWAY: mad02010
Entry
mad02010                    Pathway                                
Name
ABC transporters - Marinobacter adhaerens
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
mad02010  ABC transporters
mad02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Marinobacter adhaerens [GN:mad]
Gene
HP15_1344  thiosulfate transporter subunit [KO:K02048]
HP15_1345  sulphate ABC transporter, permease protein CysT [KO:K02046]
HP15_1346  sulfate ABC transporter, inner membrane subunit CysW [KO:K02047]
HP15_1347  sulfate/thiosulfate transporter subunit [KO:K02045] [EC:7.3.2.3]
HP15_4133  sulfate/tungstate uptake family ABC transporter, periplasmic substrate-binding protein [KO:K05772]
HP15_4135  binding-protein-dependent transport systems inner membrane component [KO:K05773]
HP15_4134  ABC-type polar amino acid transport system, ATPase component [KO:K06857] [EC:7.3.2.6]
HP15_1012  nitrate transporter component, NrtA [KO:K15576]
HP15_1013  nitrate transport system permease protein [KO:K15577]
HP15_1014  nitrate ABC transporter, ATPase subunits C and D [KO:K15578] [EC:7.3.2.4]
HP15_3304  molybdenum ABC transporter, periplasmic binding protein [KO:K02020]
HP15_3580  molybdenum ABC transporter-like protein, periplasmic binding protein [KO:K02020]
HP15_3305  molybdate ABC transporter, inner membrane subunit [KO:K02018]
HP15_3306  molybdenum ABC transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
HP15_3843  iron(III) ABC transporter, periplasmic iron-compound-binding protein [KO:K02012]
HP15_1456  extracellular solute-binding protein, family 1 [KO:K02012]
HP15_3841  iron(III) ABC transporter permease protein [KO:K02011]
HP15_1455  iron(III) ABC transporter, permease protein [KO:K02011]
HP15_3842  iron(III) ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
HP15_749  iron(III) ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
HP15_4066  extracellular solute-binding protein, family 1 [KO:K11069]
HP15_4065  spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069]
HP15_4069  binding-protein-dependent transport systems inner membrane component [KO:K11070]
HP15_4064  spermidine/putrescine ABC transporter membrane protein [KO:K11070]
HP15_4068  binding-protein-dependent transport systems inner membrane component [KO:K11071]
HP15_4063  spermidine/putrescine ABC transporter, permease protein PotB [KO:K11071]
HP15_4062  spermidine/putrescine ABC transporter, ATP-binding protein [KO:K11072] [EC:7.6.2.11]
HP15_4067  spermidine/putrescine ABC transporter ATPase subunit [KO:K11072] [EC:7.6.2.11]
HP15_940  putrescine ABC transporter, periplasmic putrescine-binding protein [KO:K11073]
HP15_937  spermidine/putrescine ABC transporter, permease protein [KO:K11074]
HP15_938  spermidine/putrescine ABC transporter, permease protein [KO:K11075]
HP15_939  spermidine/putrescine ABC transporter ATPase subunit [KO:K11076] [EC:7.6.2.16]
HP15_3296  glycine betaine/proline ABC transporter, periplasmic glycine betaine/proline-binding protein [KO:K02002]
HP15_3297  binding-protein-dependent transport systems inner membrane component [KO:K02001]
HP15_3298  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:7.6.2.9]
HP15_991  substrate-binding region of ABC-type glycine betaine transport system [KO:K05845]
HP15_993  binding-protein-dependent transport systems inner membrane component [KO:K05846]
HP15_995  binding-protein-dependent transport systems inner membrane component [KO:K05846]
HP15_994  glycine betaine/carnitine/choline ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
HP15_2955  ATP-binding component of ABC transporter [KO:K10112] [EC:7.5.2.-]
HP15_2433  toluene tolerance family protein [KO:K07323]
HP15_1570  mammalian cell entry related domain protein [KO:K02067]
HP15_2434  mammalian cell entry related domain protein [KO:K02067]
HP15_1572  ABC transporter, permease protein [KO:K02066]
HP15_2435  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
HP15_2432  NTP binding protein (contains STAS domain) [KO:K07122]
HP15_1571  ATP-binding component of ABC transporter [KO:K02065]
HP15_2436  toluene tolerance ABC efflux transporter, ATP-binding protein [KO:K02065]
HP15_2958  extracellular solute-binding protein family 1 [KO:K17315]
HP15_2957  sugar ABC transporter, permease protein [KO:K17316]
HP15_2956  sugar ABC transporter, permease protein [KO:K17317]
HP15_2170  ABC-type sugar transport system, periplasmic component [KO:K17321]
HP15_2158  ABC-type sugar transport system, periplasmic component [KO:K17321]
HP15_2162  sugar ABC transporter, permease protein [KO:K17322]
HP15_2161  sugar ABC transporter, permease protein [KO:K17323]
HP15_2164  ATP-binding protein of sugar ABC transporter [KO:K17324]
HP15_2163  sugar ABC transporter, ATP-binding protein [KO:K17325]
HP15_3270  OmpA/MotB domain protein [KO:K02040]
HP15_3389  phosphate ABC transporter periplasmic binding protein [KO:K02040]
HP15_3388  phosphate ABC transporter, inner membrane subunit PstC [KO:K02037]
HP15_3387  phosphate ABC transporter, permease protein PstA [KO:K02038]
HP15_3386  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:7.3.2.1]
HP15_1728  phosphonate ABC transporter, periplasmic phosphonate-binding protein [KO:K02044]
HP15_1730  binding-protein-dependent transport systems inner membrane component [KO:K02042]
HP15_1729  phosphonate ABC transporter, ATPase subunit [KO:K02041] [EC:7.3.2.2]
HP15_2918  glutamine ABC transporter, periplasmic glutamine-binding protein [KO:K10036]
HP15_2919  amino acid ABC transporter, permease protein [KO:K10037]
HP15_2920  amino acid ABC transporter, ATP-binding protein [KO:K10038] [EC:7.4.2.1]
HP15_2196  glutamate/glutamine/aspartate/asparagine ABC transporter, periplasmic substrate-binding protein [KO:K09969]
HP15_2195  amino acid ABC transporter, permease protein [KO:K09970]
HP15_2194  amino acid ABC transporter, permease protein [KO:K09971]
HP15_2193  yhdZ; amino-acid ABC transporter ATP-binding protein-like protein [KO:K09972] [EC:7.4.2.1]
HP15_3031  extracellular solute-binding protein, family 3 [KO:K10022]
HP15_3033  amino acid ABC transporter, inner membrane subunit [KO:K10023]
HP15_3032  amino acid ABC transporter, inner membrane subunit [KO:K10024]
HP15_3030  histidine/lysine/arginine/ornithine transporter subunit [KO:K10025] [EC:7.4.2.1]
HP15_1419  ABC transporter periplasmic amino acid-binding protein [KO:K23061]
HP15_1420  putative amino acid ABC transporter permease protein [KO:K23062]
HP15_1421  ABC transporter, membrane spanning protein [KO:K23063]
HP15_1422  amino acid ABC transporter ATP-binding protein [KO:K23064] [EC:7.4.2.1]
HP15_2707  extracellular ligand-binding receptor [KO:K01999]
HP15_2013  extracellular ligand-binding receptor [KO:K01999]
HP15_2014  extracellular ligand-binding receptor [KO:K01999]
HP15_4098  amino acids binding protein [KO:K01999]
HP15_3055  high-affinity leucine-specific leucine-specific-binding periplasmic protein of high-affinity branched-chain amino acid ABC transporter transport system periplasmic binding protein [KO:K01999]
HP15_928  extracellular ligand-binding receptor [KO:K01999]
HP15_1100  ABC-transporter substrate-binding protein [KO:K01999]
HP15_2153  extracellular ligand-binding receptor [KO:K01999]
HP15_2706  inner-membrane translocator [KO:K01997]
HP15_2015  inner-membrane translocator [KO:K01997]
HP15_4096  inner-membrane translocator [KO:K01997]
HP15_3056  high-affinity branched-chain amino acid ABC transporter, permease protein [KO:K01997]
HP15_929  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
HP15_1099  inner-membrane translocator [KO:K01997]
HP15_2016  inner-membrane translocator [KO:K01998]
HP15_4097  inner-membrane translocator [KO:K01998]
HP15_930  branched-chain amino acid transport permease [KO:K01998]
HP15_2705  inner-membrane translocator [KO:K01998]
HP15_1098  inner-membrane translocator [KO:K01998]
HP15_3057  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
HP15_2704  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
HP15_4095  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
HP15_2017  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
HP15_3058  leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995]
HP15_926  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
HP15_1097  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
HP15_4099  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
HP15_927  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
HP15_2703  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
HP15_1096  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
HP15_2018  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
HP15_3059  high-affinity branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
HP15_3905  lipoprotein, YaeC family [KO:K02073]
HP15_3904  binding-protein-dependent transport systems inner membrane component [KO:K02072]
HP15_3903  metN2; methionine import ATP-binding protein MetN 2 [KO:K02071]
HP15_3658  urea ABC transporter, urea binding protein [KO:K11959]
HP15_2881  urea short-chain amide or branched-chain amino acid uptake ABC transporter periplasmic solute-binding protein [KO:K11959]
HP15_2880  urea ABC transporter, permease protein UrtB [KO:K11960]
HP15_3657  urea ABC transporter, permease protein UrtB [KO:K11960]
HP15_3656  inner-membrane translocator [KO:K11961]
HP15_2879  urea ABC transporter, permease protein UrtC [KO:K11961]
HP15_2878  urea ABC transporter, ATP-binding protein UrtD [KO:K11962]
HP15_3655  urea ABC transporter, ATP-binding protein UrtD [KO:K11962]
HP15_2877  ABC transporter, urea, ATP-binding protein, UrtE [KO:K11963]
HP15_3654  urea ABC transporter, ATP-binding protein UrtE [KO:K11963]
HP15_1807  peptide ABC transporter, periplasmic peptide-binding protein [KO:K13893]
HP15_1808  peptide ABC transporter, permease protein [KO:K13894]
HP15_1809  peptide ABC transporter, permease protein [KO:K13895]
HP15_1810  peptide ABC transporter, ATP-binding protein [KO:K13896]
HP15_838  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K23227]
HP15_837  iron-hydroxamate transporter permease subunit [KO:K23228]
HP15_839  iron-hydroxamate transporter ATP-binding subunit [KO:K10829] [EC:7.2.2.16]
HP15_2237  ABC transporter metal-binding lipoprotein [KO:K09815]
HP15_3523  zinc ABC transporter, permease protein [KO:K09816]
HP15_3522  znuC; zinc import ATP-binding protein znuC [KO:K09817] [EC:7.2.2.20]
HP15_2070  outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808]
HP15_2069  lolD; lipoprotein-releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
HP15_2283  heme exporter protein D (cytochrome c-type biogenesis protein CcmD)-like protein [KO:K02196]
HP15_2284  heme exporter protein CcmC [KO:K02195]
HP15_2285  cytochrome c-type biogenesis protein CcmB [KO:K02194]
HP15_2286  heme exporter protein CcmA [KO:K02193] [EC:7.6.2.5]
HP15_1316  permease YjgP/YjgQ family protein [KO:K07091]
HP15_1317  permease YjgP/YjgQ family protein [KO:K11720]
HP15_2441  protein containing ABC transporter-like domain [KO:K06861] [EC:7.5.2.5]
HP15_3488  ftsX; cell division protein FtsX-like protein [KO:K09811]
HP15_3489  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
HP15_2064  lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA [KO:K11085] [EC:7.5.2.6]
HP15_3710  ABC transporter, ATP-binding/permease protein [KO:K24821]
HP15_1749  transport ATP-binding protein CydC [KO:K16012]
HP15_1748  cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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