KEGG   PATHWAY: mcab02010
Entry
mcab02010                   Pathway                                
Name
ABC transporters - Micromonospora carbonacea
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
mcab02010  ABC transporters
mcab02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Micromonospora carbonacea [GN:mcab]
Gene
HXZ27_26590  ABC transporter substrate-binding protein [KO:K15553]
HXZ27_26600  ABC transporter permease [KO:K15554]
HXZ27_26595  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
HXZ27_19255  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
HXZ27_19260  modB; molybdate ABC transporter permease subunit [KO:K02018]
HXZ27_19265  ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
HXZ27_23885  extracellular solute-binding protein [KO:K02012]
HXZ27_23875  iron ABC transporter permease [KO:K02011]
HXZ27_23880  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
HXZ27_05765  spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069]
HXZ27_05780  ABC transporter permease [KO:K11070]
HXZ27_05775  ABC transporter permease [KO:K11071]
HXZ27_05770  ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
HXZ27_29255  glycine/betaine ABC transporter substrate-binding protein [KO:K05845]
HXZ27_29260  ABC transporter permease subunit [KO:K05846]
HXZ27_29265  ABC transporter permease [KO:K05846]
HXZ27_29270  ATP-binding cassette domain-containing protein [KO:K05847] [EC:7.6.2.9]
HXZ27_02825  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
HXZ27_20930  ATP-binding cassette domain-containing protein [KO:K10112] [EC:7.5.2.-]
HXZ27_20935  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
HXZ27_21295  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10112] [EC:7.5.2.-]
HXZ27_28930  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10112] [EC:7.5.2.-]
HXZ27_04765  maltose ABC transporter substrate-binding protein [KO:K15770]
HXZ27_04770  ABC transporter permease subunit [KO:K15771]
HXZ27_04775  sugar ABC transporter permease [KO:K15772]
HXZ27_12750  extracellular solute-binding protein [KO:K10117]
HXZ27_13795  extracellular solute-binding protein [KO:K10117]
HXZ27_15010  extracellular solute-binding protein [KO:K10117]
HXZ27_21360  extracellular solute-binding protein [KO:K10117]
HXZ27_12755  sugar ABC transporter permease [KO:K10118]
HXZ27_13800  sugar ABC transporter permease [KO:K10118]
HXZ27_15015  sugar ABC transporter permease [KO:K10118]
HXZ27_21365  sugar ABC transporter permease [KO:K10118]
HXZ27_12760  carbohydrate ABC transporter permease [KO:K10119]
HXZ27_13805  carbohydrate ABC transporter permease [KO:K10119]
HXZ27_15020  carbohydrate ABC transporter permease [KO:K10119]
HXZ27_21370  carbohydrate ABC transporter permease [KO:K10119]
HXZ27_15715  carbohydrate ABC transporter substrate-binding protein [KO:K10232]
HXZ27_16815  carbohydrate ABC transporter substrate-binding protein [KO:K10232]
HXZ27_25530  carbohydrate ABC transporter substrate-binding protein [KO:K10232]
HXZ27_15720  ABC transporter permease subunit [KO:K10233]
HXZ27_25535  sugar ABC transporter permease [KO:K10233]
HXZ27_15725  carbohydrate ABC transporter permease [KO:K10234]
HXZ27_25540  carbohydrate ABC transporter permease [KO:K10234]
HXZ27_14750  extracellular solute-binding protein [KO:K17318]
HXZ27_18930  extracellular solute-binding protein [KO:K17318]
HXZ27_14760  sugar ABC transporter permease [KO:K17319]
HXZ27_18935  sugar ABC transporter permease [KO:K17319]
HXZ27_14755  carbohydrate ABC transporter permease [KO:K17320]
HXZ27_18940  carbohydrate ABC transporter permease [KO:K17320]
HXZ27_21310  ABC transporter substrate-binding protein [KO:K10236]
HXZ27_21305  sugar ABC transporter permease [KO:K10237]
HXZ27_21300  carbohydrate ABC transporter permease [KO:K10238]
HXZ27_21415  ngcE; carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein [KO:K10200]
HXZ27_21410  sugar ABC transporter permease [KO:K10201]
HXZ27_21405  carbohydrate ABC transporter permease [KO:K10202]
HXZ27_07575  extracellular solute-binding protein [KO:K10240]
HXZ27_09585  extracellular solute-binding protein [KO:K10240]
HXZ27_28405  extracellular solute-binding protein [KO:K10240]
HXZ27_07580  sugar ABC transporter permease [KO:K10241]
HXZ27_09590  sugar ABC transporter permease [KO:K10241]
HXZ27_28410  sugar ABC transporter permease [KO:K10241]
HXZ27_07585  carbohydrate ABC transporter permease [KO:K10242]
HXZ27_09595  carbohydrate ABC transporter permease [KO:K10242]
HXZ27_28415  carbohydrate ABC transporter permease [KO:K10242]
HXZ27_24645  sugar ABC transporter substrate-binding protein [KO:K17329]
HXZ27_24640  sugar ABC transporter permease [KO:K17330]
HXZ27_24635  carbohydrate ABC transporter permease [KO:K17331]
HXZ27_18000  sugar-binding protein [KO:K10546]
HXZ27_17990  sugar ABC transporter permease [KO:K10547]
HXZ27_17995  ATP-binding cassette domain-containing protein [KO:K10548] [EC:7.5.2.-]
HXZ27_04790  BMP family ABC transporter substrate-binding protein [KO:K07335]
HXZ27_12910  BMP family ABC transporter substrate-binding protein [KO:K07335]
HXZ27_04800  ABC transporter permease [KO:K23535]
HXZ27_12920  ABC transporter permease [KO:K23535]
HXZ27_04805  ABC transporter permease [KO:K23536]
HXZ27_12925  ABC transporter permease [KO:K23536]
HXZ27_04795  ABC transporter ATP-binding protein [KO:K23537]
HXZ27_12915  ABC transporter ATP-binding protein [KO:K23537]
HXZ27_14920  substrate-binding domain-containing protein [KO:K10439]
HXZ27_11905  sugar ABC transporter substrate-binding protein [KO:K10439]
HXZ27_16555  substrate-binding domain-containing protein [KO:K10439]
HXZ27_24315  substrate-binding domain-containing protein [KO:K10439]
HXZ27_14915  ABC transporter permease [KO:K10440]
HXZ27_16550  ATP-binding cassette domain-containing protein [KO:K10440 K10441] [EC:7.5.2.7]
HXZ27_16560  ABC transporter permease [KO:K10440]
HXZ27_24320  ABC transporter permease [KO:K10440]
HXZ27_24325  sugar ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
HXZ27_14930  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
HXZ27_13705  ABC transporter substrate-binding protein [KO:K23508]
HXZ27_13715  ABC transporter permease [KO:K23509]
HXZ27_13720  yjfF; sugar ABC transporter permease YjfF [KO:K23509]
HXZ27_13710  sugar ABC transporter ATP-binding protein [KO:K10820] [EC:7.5.2.9]
HXZ27_27200  substrate-binding domain-containing protein [KO:K10543]
HXZ27_27210  ABC transporter permease [KO:K10544]
HXZ27_27205  sugar ABC transporter ATP-binding protein [KO:K10545] [EC:7.5.2.10]
HXZ27_28590  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
HXZ27_28595  pstC; phosphate ABC transporter permease subunit PstC [KO:K02037]
HXZ27_28600  pstA; phosphate ABC transporter permease PstA [KO:K02038]
HXZ27_28605  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
HXZ27_08785  transporter substrate-binding domain-containing protein [KO:K10005]
HXZ27_09025  glutamate ABC transporter substrate-binding protein [KO:K10005]
HXZ27_29545  transporter substrate-binding domain-containing protein [KO:K10005]
HXZ27_09020  amino acid ABC transporter permease [KO:K10006]
HXZ27_09015  amino acid ABC transporter permease [KO:K10007]
HXZ27_09030  amino acid ABC transporter ATP-binding protein [KO:K10008] [EC:7.4.2.1]
HXZ27_00935  ABC transporter substrate-binding protein [KO:K01999]
HXZ27_22210  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
HXZ27_27385  ABC transporter substrate-binding protein [KO:K01999]
HXZ27_28040  substrate-binding domain-containing protein [KO:K01999]
HXZ27_31345  ABC transporter substrate-binding protein [KO:K01999]
HXZ27_22205  branched-chain amino acid ABC transporter permease [KO:K01997]
HXZ27_28025  branched-chain amino acid ABC transporter permease [KO:K01997]
HXZ27_22200  branched-chain amino acid ABC transporter permease [KO:K01998]
HXZ27_28020  branched-chain amino acid ABC transporter permease [KO:K01998]
HXZ27_22195  ABC transporter ATP-binding protein [KO:K01995]
HXZ27_28035  ABC transporter ATP-binding protein [KO:K01995]
HXZ27_22190  ABC transporter ATP-binding protein [KO:K01996]
HXZ27_28030  ABC transporter ATP-binding protein [KO:K01996]
HXZ27_13245  substrate-binding domain-containing protein [KO:K11959]
HXZ27_13250  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
HXZ27_13255  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
HXZ27_13260  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
HXZ27_13265  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
HXZ27_13270  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
HXZ27_27060  ABC transporter substrate-binding protein [KO:K15580]
HXZ27_27055  ABC transporter permease [KO:K15581]
HXZ27_27050  ABC transporter permease [KO:K15582]
HXZ27_27045  ABC transporter ATP-binding protein [KO:K15583]
HXZ27_27040  dipeptide ABC transporter ATP-binding protein [KO:K10823]
HXZ27_14005  ABC transporter substrate-binding protein [KO:K25287]
HXZ27_01480  iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
HXZ27_24160  iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
HXZ27_11205  iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
HXZ27_01475  iron ABC transporter permease [KO:K23186]
HXZ27_11190  iron ABC transporter permease [KO:K23186]
HXZ27_14000  iron ABC transporter permease [KO:K23186]
HXZ27_24165  iron chelate uptake ABC transporter family permease subunit [KO:K23186]
HXZ27_01470  iron chelate uptake ABC transporter family permease subunit [KO:K23187]
HXZ27_11195  iron ABC transporter permease [KO:K23187]
HXZ27_13995  iron chelate uptake ABC transporter family permease subunit [KO:K23187]
HXZ27_24170  iron chelate uptake ABC transporter family permease subunit [KO:K23187]
HXZ27_01465  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
HXZ27_11200  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
HXZ27_13990  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
HXZ27_24175  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
HXZ27_24430  zinc ABC transporter substrate-binding protein [KO:K09815]
HXZ27_24440  metal ABC transporter permease [KO:K09816]
HXZ27_24435  metal ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
HXZ27_07275  PDGLE domain-containing protein [KO:K02009]
HXZ27_07270  energy-coupling factor ABC transporter permease [KO:K02007]
HXZ27_07280  cbiQ; cobalt ECF transporter T component CbiQ [KO:K02008]
HXZ27_07285  ATP-binding cassette domain-containing protein [KO:K02006]
HXZ27_24520  energy-coupling factor transporter transmembrane protein EcfT [KO:K16785]
HXZ27_10770  ABC transporter permease [KO:K09692]
HXZ27_10765  ABC transporter ATP-binding protein [KO:K09693] [EC:7.5.2.4]
HXZ27_07425  ABC transporter permease [KO:K18233]
HXZ27_07420  ATP-binding cassette domain-containing protein [KO:K18232]
HXZ27_06600  ABC transporter permease [KO:K09811]
HXZ27_06595  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
HXZ27_04990  ABC transporter ATP-binding protein [KO:K18887]
HXZ27_04985  ABC transporter ATP-binding protein [KO:K18888]
HXZ27_04870  cydC; thiol reductant ABC exporter subunit CydC [KO:K16012]
HXZ27_06100  rosA; ABC-F type ribosomal protection protein [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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