KEGG   PATHWAY: mchn03060
Entry
mchn03060                   Pathway                                
Name
Protein export - Microbacterium chengjingii
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mchn03060  Protein export
mchn03060

Other DBs
GO: 0043952 0043953
Organism
Microbacterium chengjingii [GN:mchn]
Gene
HCR76_03490  secY; preprotein translocase subunit SecY [KO:K03076]
HCR76_02860  secE; preprotein translocase subunit SecE [KO:K03073]
HCR76_08005  secG; preprotein translocase subunit SecG [KO:K03075]
HCR76_08370  secD; protein translocase subunit SecD [KO:K03072]
HCR76_08365  secF; protein translocase subunit SecF [KO:K03074]
HCR76_08375  yajC; preprotein translocase subunit YajC [KO:K03210]
HCR76_01265  YidC/Oxa1 family membrane protein insertase [KO:K03217]
HCR76_17455  yidC; membrane protein insertase YidC [KO:K03217]
HCR76_10620  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
HCR76_07140  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
HCR76_11925  ffs; signal recognition particle sRNA small type [KO:K01983]
HCR76_07120  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
HCR76_14465  ArsA family ATPase [KO:K01551] [EC:7.3.2.7 7.3.-.-]
HCR76_03965  tatA; twin-arginine translocase TatA/TatE family subunit [KO:K03116]
HCR76_07780  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
HCR76_06230  Sec-independent protein translocase TatB [KO:K03117]
HCR76_07775  tatC; twin-arginine translocase subunit TatC [KO:K03118]
HCR76_07185  lepB; signal peptidase I [KO:K03100] [EC:3.4.21.89]
HCR76_11570  lepB; signal peptidase I [KO:K03100] [EC:3.4.21.89]
HCR76_07580  lspA; signal peptidase II [KO:K03101] [EC:3.4.23.36]
HCR76_11780  signal peptidase I [KO:K13280] [EC:3.4.21.89]
HCR76_12670  signal peptidase I [KO:K13280] [EC:3.4.21.89]
HCR76_12680  hypothetical protein [KO:K13280] [EC:3.4.21.89]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
LinkDB

DBGET integrated database retrieval system