Entry
Name
Tuberculosis - Mycobacterium canettii CIPT 140060008
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mycobacterium canettii CIPT 140060008 [GN:
mcq ]
Gene
BN44_11020 pstS; Periplasmic phosphate ABC transporter substrate-binding protein PstS3 (PBP-3) (PSTS3) (PHOS1) [KO:K02040 ]
BN44_11024 pstS; Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PSTS2) [KO:K02040 ]
BN44_11026 pstS; Phosphate-binding lipoprotein PstS1 (PBP-1) (PSTS1) [KO:K02040 ]
BN44_10391 dnaK; Putative chaperone protein DnaK (Heat Shock Protein 70) (Heat Shock 70 kDa Protein) (HSP70) [KO:K04043 ]
BN44_10485 groEL; 60 kDa chaperonin 2 GroEL2 (protein cpn60.2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A) [KO:K04077 ] [EC:5.6.1.7 ]
BN44_120009 esxW; Conserved protein of unknown function, putative ESAT-6 like protein EsxW (ESAT-6 Like Protein 10) [KO:K14956 ]
BN44_120323 Conserved protein of unknown function, putative ESAT-6-like protein 11 [KO:K14956 ]
BN44_120340 esxF; ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13) [KO:K14956 ]
BN44_11338 Putative ESAT-6-like protein EsxJ (ESAT-6-like protein 2) [KO:K14956 ]
BN44_60505 esxQ; Conserved protein of unknown function, ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8) [KO:K14956 ]
BN44_60513 esxR; Conserved exported protein of unknown function, ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9) [KO:K14956 ]
BN44_60514 esxS; Conserved protein of unknown function, ESAT-6 like protein EsxS [KO:K14956 ]
BN44_120008 esxV; Conserved protein of unknown function, ESAT-6 like protein EsxN (ESAT-6 like protein 5) [KO:K14956 ]
BN44_10331 esxG; ESAT-6 like protein EsxG (conserved hypothetical protein TB9.8) [KO:K14956 ]
BN44_11154 esxV; Putative Esat-6 like protein EsxV (Esat-6 like protein 1) [KO:K14956 ]
BN44_120339 esxE; ESAT-6 like protein EsxE (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 12) [KO:K14956 ]
BN44_11339 esxV; Conserved protein of unknown function, putative ESAT-6 like protein EsxN (ESAT-6 like protein 4) [KO:K14956 ]
BN44_50312 esxN; Conserved protein of unknown function, Esat-6 like protein EsxO (Esat-6 like protein 6) [KO:K14956 ]
BN44_70103 sapM; Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) [KO:K21302 ] [EC:3.1.3.64 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124 Sphingosine 1-phosphate
C19190 Trehalose-6,6'-dibehenate
C21790 Mycobacterial trehalose dimycolate
G13105 Triacylated phosphatidyl-myo-inositol pentamannoside
G13106 Triacylated phosphatidyl-myo-inositol hexamannoside
G13108 Triacylated phosphatidyl-myo-inositol dimannoside
G13109 Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112 Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113 Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13115 Mannose-capped lipoarabinomannan
Reference
Authors
Saiga H, Shimada Y, Takeda K
Title
Innate immune effectors in mycobacterial infection.
Journal
Reference
Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
Title
The immunology of tuberculosis: from bench to bedside.
Journal
Reference
Authors
van Crevel R, Ottenhoff TH, van der Meer JW
Title
Innate immunity to Mycobacterium tuberculosis.
Journal
Reference
Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
Title
Role of C-type lectins in mycobacterial infections.
Journal
Reference
Authors
Jo EK, Yang CS, Choi CH, Harding CV
Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Journal
Reference
Authors
Marakalala MJ, Graham LM, Brown GD
Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
Journal
Reference
Authors
Koul A, Herget T, Klebl B, Ullrich A
Title
Interplay between mycobacteria and host signalling pathways.
Journal
Reference
Authors
Torrelles JB, Schlesinger LS
Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
Journal
Reference
Authors
Briken V, Porcelli SA, Besra GS, Kremer L
Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Journal
Reference
Authors
Baena A, Porcelli SA
Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
Journal
Reference
Authors
Flannagan RS, Cosio G, Grinstein S
Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Journal
Reference
Authors
Pieters J
Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Journal
Reference
Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
Title
Interference of Mycobacterium tuberculosis with macrophage responses.
Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
Title
Regulation of MHC class II gene expression by the class II transactivator.
Journal
Reference
Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
Journal
Reference
Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
Title
Mycobacterium tuberculosis prevents inflammasome activation.
Journal
Reference
Authors
Shtrichman R, Samuel CE
Title
The role of gamma interferon in antimicrobial immunity.
Journal
Related pathway
mcq00571 Lipoarabinomannan (LAM) biosynthesis
KO pathway
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