KEGG   PATHWAY: ko05152
ko05152                     Pathway                                
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Human Diseases; Infectious disease: bacterial
Pathway map
ko05152  Tuberculosis

H00342  Tuberculosis
K03156  tumor necrosis factor superfamily, member 2
K03158  tumor necrosis factor receptor superfamily member 1A
K03171  tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373  FAS-associated death domain protein
K04398  caspase 8 [EC:]
K04400  caspase 10 [EC:]
K02187  caspase 3 [EC:]
K04726  BH3 interacting domain death agonist
K02159  apoptosis regulator BAX
K08738  cytochrome c
K04399  caspase 9 [EC:]
K02084  apoptotic protease-activating factor
K04456  RAC serine/threonine-protein kinase [EC:]
K02158  Bcl-2-antagonist of cell death
K02161  apoptosis regulator Bcl-2
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:]
K04687  interferon gamma
K05132  interferon gamma receptor 1
K05133  interferon gamma receptor 2
K11217  Janus kinase 1 [EC:]
K04447  Janus kinase 2 [EC:]
K11220  signal transducer and activator of transcription 1
K08060  MHC class II transactivator [EC:]
K08061  regulatory factor X 5
K08062  regulatory factor X-associated ankyrin-containing protein
K08063  regulatory factor X-associated protein
K08064  nuclear transcription factor Y, alpha
K08065  nuclear transcription Y subunit beta
K08066  nuclear transcription factor Y, gamma
K05870  cyclic AMP-responsive element-binding protein 1
K06752  MHC class II antigen
K06505  CD74 antigen
K04498  E1A/CREB-binding protein [EC:]
K05443  interleukin 10
K05134  interleukin 10 receptor alpha
K05135  interleukin 10 receptor beta
K01368  cathepsin S [EC:]
K10059  C-type lectin domain family 4 member E
K07983  high affinity immunoglobulin epsilon receptor subunit gamma
K10074  C-type lectin domain family 7 member A
K05704  tyrosine-protein kinase Src [EC:]
K05855  spleen tyrosine kinase [EC:]
K12794  caspase recruitment domain-containing protein 9
K07369  mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K07368  B-cell CLL/lymphoma 10
K14952  UDP-MurNAc hydroxylase
K10165  nucleotide-binding oligomerization domain-containing protein 2
K08846  receptor-interacting serine/threonine-protein kinase 2 [EC:]
K14953  ipoprotein LpqH
K14954  lipoprotein LprG
K14955  lipoprotein LprA
K02040  phosphate transport system substrate-binding protein
K04043  molecular chaperone DnaK
K04077  chaperonin GroEL [EC:]
K14956  6 kDa early secretory antigenic target
K05399  lipopolysaccharide-binding protein
K10159  toll-like receptor 2
K05398  toll-like receptor 1
K10169  toll-like receptor 6
K10160  toll-like receptor 4
K04391  monocyte differentiation antigen CD14
K05403  toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K04729  myeloid differentiation primary response protein MyD88
K04733  interleukin-1 receptor-associated kinase 4 [EC:]
K04730  interleukin-1 receptor-associated kinase 1 [EC:]
K04731  interleukin-1 receptor-associated kinase 2 [EC:]
K03175  TNF receptor-associated factor 6 [EC:]
K02580  nuclear factor NF-kappa-B p105 subunit
K04735  transcription factor p65
K04441  p38 MAP kinase [EC:]
K04371  mitogen-activated protein kinase 1/3 [EC:]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:]
K13241  nitric-oxide synthase, inducible [EC:]
K05405  interleukin 6
K05406  interleukin 12A
K05425  interleukin 12B
K05482  interleukin 18
K05426  interleukin 23 subunit alpha
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K10048  CCAAT/enhancer binding protein (C/EBP), beta
K10049  CCAAT/enhancer binding protein (C/EBP), gamma
K10161  toll-like receptor 9
K05414  interferon alpha
K05415  interferon beta
K06563  C-type lectin domain family 4 member L/M
K07532  Rho guanine nucleotide exchange factor 12
K04513  Ras homolog gene family, member A
K14957  lymphocyte-specific protein 1
K08862  polo-like kinase 3 [EC:]
K14958  kinase suppressor of Ras 1
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:]
K13375  transforming growth factor beta-1
K13376  transforming growth factor beta-2
K13377  transforming growth factor beta-3
K07438  calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:]
K08539  vitamin D3 receptor
K13916  cathelicidin antimicrobial peptide
K03990  complement component 3
K04011  complement component (3b/4b) receptor 1
K06462  integrin alpha X
K06464  integrin beta 2
K06461  integrin alpha M
K06560  mannose receptor, C type
K04718  sphingosine kinase [EC:]
K02183  calmodulin
K00914  phosphatidylinositol 3-kinase [EC:]
K07887  Ras-related protein Rab-5A
K07888  Ras-related protein Rab-5B
K07889  Ras-related protein Rab-5C
K12478  early endosome antigen 1
K07897  Ras-related protein Rab-7A
K01379  cathepsin D [EC:]
K02154  V-type H+-transporting ATPase subunit a
K02146  V-type H+-transporting ATPase subunit d
K02144  V-type H+-transporting ATPase subunit H
K03662  V-type H+-transporting ATPase S1 subunit
K02155  V-type H+-transporting ATPase 16kDa proteolipid subunit
K03661  V-type H+-transporting ATPase 21kDa proteolipid subunit
K06528  lysosomal-associated membrane protein 1/2
K21302  phosphatidylinositol-3-phosphatase [EC:]
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:]
K06268  serine/threonine-protein phosphatase 2B regulatory subunit
K13882  coronin-1A
K14949  serine/threonine-protein kinase PknG [EC:]
K06856  immunoglobulin heavy chain
K06498  high affinity immunoglobulin gamma Fc receptor I
K06472  low affinity immunoglobulin gamma Fc receptor II-a
K12560  low affinity immunoglobulin gamma Fc receptor II-b
K16824  low affinity immunoglobulin gamma Fc receptor II-c
K06463  low affinity immunoglobulin gamma Fc receptor III
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Saiga H, Shimada Y, Takeda K
Innate immune effectors in mycobacterial infection.
Clin Dev Immunol 2011:347594 (2011)
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
The immunology of tuberculosis: from bench to bedside.
Respirology 15:433-50 (2010)
van Crevel R, Ottenhoff TH, van der Meer JW
Innate immunity to Mycobacterium tuberculosis.
Clin Microbiol Rev 15:294-309 (2002)
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
Role of C-type lectins in mycobacterial infections.
Curr Drug Targets 9:102-12 (2008)
Jo EK, Yang CS, Choi CH, Harding CV
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Cell Microbiol 9:1087-98 (2007)
Marakalala MJ, Graham LM, Brown GD
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
Clin Dev Immunol 2010:567571 (2010)
Koul A, Herget T, Klebl B, Ullrich A
Interplay between mycobacteria and host signalling pathways.
Nat Rev Microbiol 2:189-202 (2004)
Torrelles JB, Schlesinger LS
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
Tuberculosis (Edinb) 90:84-93 (2010)
Briken V, Porcelli SA, Besra GS, Kremer L
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Mol Microbiol 53:391-403 (2004)
Baena A, Porcelli SA
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
Tissue Antigens 74:189-204 (2009)
Flannagan RS, Cosio G, Grinstein S
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Nat Rev Microbiol 7:355-66 (2009)
Pieters J
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Cell Host Microbe 3:399-407 (2008)
Scherr N, Jayachandran R, Mueller P, Pieters J
Interference of Mycobacterium tuberculosis with macrophage responses.
Indian J Exp Biol 47:401-6 (2009)
Reith W, LeibundGut-Landmann S, Waldburger JM.
Regulation of MHC class II gene expression by the class II transactivator.
Nat Rev Immunol 5:793-806 (2005)
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
J Immunol 179:3463-71 (2007)
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
Mycobacterium tuberculosis prevents inflammasome activation.
Cell Host Microbe 3:224-32 (2008)
Shtrichman R, Samuel CE
The role of gamma interferon in antimicrobial immunity.
Curr Opin Microbiol 4:251-9 (2001)
ko00571  Lipoarabinomannan (LAM) biosynthesis
ko04010  MAPK signaling pathway
ko04210  Apoptosis
ko04612  Antigen processing and presentation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04630  JAK-STAT signaling pathway

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