PATHWAY: mcx02010 Help
Entry Name ABC transporters - Mycobacterium canettii CIPT 140070010
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mycobacterium canettii CIPT 140070010 [GN:
mcx ]
Gene BN42_40338 cysT; Putative sulfate-transport integral membrane protein ABC transporter CysT [KO:K02046 ]
BN42_40337 cysW; Putative sulfate-transport integral membrane protein ABC transporter CysW [KO:K02047 ]
BN42_30121 modB; Putative molbdenum-transport integral membrane protein ABC transporter ModB [KO:K02018 ]
BN42_90278 proX; Putative osmoprotectant (glycine betaine/carnitine/choline/l-proline) binding lipoprotein ProX [KO:K05845 ]
BN42_90275 proZ; Putative osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter ProZ [KO:K05846 ]
BN42_90276 proW; Putative osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter ProW [KO:K05846 ]
BN42_90277 proV; Putative osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport ATP-binding protein ABC transporter ProV [KO:K05847 ] [EC:7.6.2.9 ]
BN42_30342 Putative sugar-transport ATP-binding protein ABC transporter [KO:K10112 ] [EC:7.5.2.-]
BN42_21111 sugC; Putative sugar-transport ATP-binding protein ABC transporter SugC [KO:K10112 ] [EC:7.5.2.-]
BN42_21108 lpqY; Conserved lipoprotein of unknown function, sugar-binding lipoprotein lpqY [KO:K10236 ]
BN42_21109 sugA; Putative sugar-transport integral membrane protein ABC transporter SugA [KO:K10237 ]
BN42_21110 sugB; Putative sugar-transport integral membrane protein ABC transporter SugB [KO:K10238 ]
BN42_10216 lprK; Conserved lipoprotein of unknown function, MCE family Mce1E/LprK, involved in entry and survival inside cells [KO:K02067 ]
BN42_10217 mce1F; Conserved protein of unknown function, MCE family Mce1F, involved in entry and survival inside cells [KO:K02067 ]
BN42_10212 mce1A; Conserved protein of unknown function, MCE family Mce1A, involved in entry and survival inside cells [KO:K02067 ]
BN42_10213 mce1B; Conserved protein of unknown function, MCE family Mce1B, involved in entry and survival inside cells [KO:K02067 ]
BN42_10214 mce1C; Conserved protein of unknown function, MCE family Mce1C, involved in entry and survival inside cells [KO:K02067 ]
BN42_50172 mce4F; Conserved protein of unknown function, MCE-family protein Mce4F [KO:K02067 ]
BN42_50173 lprN; Putative MCE-family lipoprotein LprN (MCE-family lipoprotein Mce4E) [KO:K02067 ]
BN42_50174 mce4D; Conserved protein of unknown function, MCE-family protein Mce4D, thought to be involved in host cell invasion. Predicted to be involved in lipid catabolism [KO:K02067 ]
BN42_50175 mce4C; Conserved protein of unknown function, MCE-family protein Mce4C, thought to be involved in host cell invasion. Predicted to be involved in lipid catabolism [KO:K02067 ]
BN42_50176 mce4B; Conserved protein of unknown function, MCE-family protein Mce4B, thought to be involved in host cell invasion. Predicted to be involved in lipid catabolism [KO:K02067 ]
BN42_50177 mce4A; Conserved protein of unknown function, MCE-family protein Mce4A, thought to be involved in host cell invasion. Predicted to be involved in lipid catabolism [KO:K02067 ]
BN42_30253 mce3A; Conserved protein of unknown function, MCE family Mce3A, thought to be involved in host cell invasion [KO:K02067 ]
BN42_30254 mce3B; Conserved protein of unknown function, MCE family Mce3B, thought to be involved in host cell invasion [KO:K02067 ]
BN42_30255 mce3C; Conserved protein of unknown function, MCE family Mce3C, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20336 mce2A; Conserved protein of unknown function, MCE family, Mce2A, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20337 Conserved protein of unknown function, MCE family, Mce2B, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20338 mce2C; Conserved protein of unknown function, MCE family, Mce2C, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20339 mce2D; Conserved protein of unknown function, MCE family, MCE2D, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20340 lprL; Conserved lipoprotein of unknown function, MCE-family lipoprotein Mce2E, thought to be involved in host cell invasion [KO:K02067 ]
BN42_20341 mce2F; Conserved protein of unknown function, MCE family Mce2F, thought to be involved in host cell invasion [KO:K02067 ]
BN42_30256 mce3D; Conserved protein of unknown function MCE-family protein Mce3D [KO:K02067 ]
BN42_30257 Conserved lipoprotein of unknown function, MCE family Mce3E, thought to be involved in host cell invasion [KO:K02067 ]
BN42_30258 mce3F; Conserved protein of unknown function, MCE family Mce3F, thought to be involved in host cell invasion [KO:K02067 ]
BN42_10215 mce1D; Conserved protein of unknown function, MCE family Mce1D, involved in entry and survival inside cells [KO:K02067 ]
BN42_10210 yrbE1A; Conserved membrane protein of unknown function YrbE1A [KO:K02066 ]
BN42_10211 yrbE1B; Conserved membrane protein of unknown function YrbE1B [KO:K02066 ]
BN42_50178 yrbE4B; Putative ABC transporter integral membrane subunit, YrbE4b [KO:K02066 ]
BN42_50179 yrbE4A; Conserved integral membrane protein of unknown function, protein YrbE4a. Putative ABC transporter [KO:K02066 ]
BN42_30251 yrbE3A; Conserved membrane protein of unknown function, YrbE3a [KO:K02066 ]
BN42_30252 yrbE3B; Conserved membrane protein of unknown function, YrbE3B [KO:K02066 ]
BN42_20334 yrbE2A; Conserved membrane protein of unknown function, YrbE2A [KO:K02066 ]
BN42_20335 yrbE2B; Conserved membrane protein of unknown function, YrbE2B [KO:K02066 ]
BN42_20399 mkl; Putative ribonucleotide transport ATP-binding protein Mkl [KO:K02065 ]
BN42_40818 Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB [KO:K05813 ]
BN42_40821 ugpA; Putative Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA [KO:K05814 ]
BN42_40820 ugpE; Putative Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE [KO:K05815 ]
BN42_40817 ugpC; Putative Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC [KO:K05816 ] [EC:7.6.2.10 ]
BN42_20737 pstS; Periplasmic phosphate ABC transporter substrate-binding protein PstS3 (PBP-3) (PSTS3) (PHOS1) [KO:K02040 ]
BN42_20741 pstS; Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PSTS2) [KO:K02040 ]
BN42_20744 pstS; Phosphate-binding lipoprotein PstS1 (PBP-1) (PSTS1) [KO:K02040 ]
BN42_20738 pstC; Phosphate-transport integral membrane ABC transporter PstC2 [KO:K02037 ]
BN42_20745 pstC; Phosphate-transport integral membrane ABC transporter PstC1 [KO:K02037 ]
BN42_20739 pstA; Putative phosphate-transport integral membrane ABC transporter PstA1 [KO:K02038 ]
BN42_20746 pstA; Phosphate-transport integral membrane ABC transporter PstA2 [KO:K02038 ]
BN42_90178 dppA; Putative periplasmic dipeptide-binding lipoprotein DppA [KO:K15580 ]
BN42_90177 dppB; Putative dipeptide-transport integral membrane protein ABC transporter dppB [KO:K15581 ]
BN42_90176 dppC; Putative Dipeptide-transport integral membrane protein ABC transporter DppC [KO:K15582 ]
BN42_90175 yliA; Putative peptide transport fused subunits of ABC superfamily: ATP-binding components [KO:K10823 K15583 ]
BN42_21158 oppA; Putative periplasmic oligopeptide-binding lipoprotein OppA [KO:K13889 ]
BN42_21161 oppB; Putative oligopeptide-transport integral membrane protein ABC transporter OppB [KO:K13890 ]
BN42_21160 oppC; Putative oligopeptide-transport integral membrane protein ABC transporter OppC [KO:K13891 ]
BN42_21159 oppD; Putative oligopeptide-transport ATP-binding protein ABC transporter OppD [KO:K13892 ]
BN42_90306 rfbD; Putative O-antigen/lipopolysaccharide transport ABC transporter permease RfbD [KO:K09690 ]
BN42_90304 rfbE; Putative O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE [KO:K09691 ] [EC:7.5.2.14 ]
BN42_40661 Putative antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter [KO:K16906 ]
BN42_40663 Putative antibiotic-transport ATP-binding protein ABC transporter [KO:K16907 ] [EC:7.6.2.-]
BN42_41133 ftsX; Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) [KO:K09811 ]
BN42_41134 ftsE; Transporter subunit: ATP-binding component of ABC superfamily [KO:K09812 ]
BN42_21258 Iron import ATP-binding/permease protein IrtA (Iron-regulated transporter A) [KO:K14698 ] [EC:7.-.-.-]
BN42_21259 Putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K14699 ] [EC:7.-.-.-]
BN42_10238 Putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K18894 ]
BN42_21150 Putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K18887 ]
BN42_21543 cydC; Putative component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydC [KO:K16012 ]
BN42_21544 cydD; Fused cysteine transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K16013 ]
BN42_30079 Putative drugs-transport transmembrane ATP-binding protein ABC transporter [KO:K02471 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
