KEGG   PATHWAY: mil02010
Entry
mil02010                    Pathway                                
Name
ABC transporters - Micromonospora sp. L5
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
mil02010  ABC transporters
mil02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Micromonospora sp. L5 [GN:mil]
Gene
ML5_4813  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
ML5_2994  aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553]
ML5_4812  binding-protein-dependent transport systems inner membrane component [KO:K15554]
ML5_2992  binding-protein-dependent transport systems inner membrane component [KO:K15554]
ML5_4811  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
ML5_2993  ABC transporter related protein [KO:K15555] [EC:7.6.2.14]
ML5_4779  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
ML5_4780  molybdate ABC transporter, inner membrane subunit [KO:K02018]
ML5_4781  ABC transporter related protein [KO:K02017] [EC:7.3.2.5]
ML5_4628  iron ABC transporter substrate-binding protein [KO:K02012]
ML5_4630  binding-protein-dependent transport systems inner membrane component [KO:K02011]
ML5_4629  ABC transporter related protein [KO:K02010] [EC:7.2.2.7]
ML5_1212  extracellular solute-binding protein family 1 [KO:K11069]
ML5_1215  binding-protein-dependent transport systems inner membrane component [KO:K11070]
ML5_1214  binding-protein-dependent transport systems inner membrane component [KO:K11071]
ML5_1213  ABC transporter related protein [KO:K11072] [EC:7.6.2.11]
ML5_2631  Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845]
ML5_2629  binding-protein-dependent transport systems inner membrane component [KO:K05846]
ML5_2630  binding-protein-dependent transport systems inner membrane component [KO:K05846]
ML5_2628  ABC transporter related protein [KO:K05847] [EC:7.6.2.9]
ML5_2692  ABC transporter related protein [KO:K10112] [EC:7.5.2.-]
ML5_4126  ABC transporter related protein [KO:K10112] [EC:7.5.2.-]
ML5_0720  ABC transporter related protein [KO:K10112] [EC:7.5.2.-]
ML5_1012  extracellular solute-binding protein family 1 [KO:K15770]
ML5_1013  binding-protein-dependent transport systems inner membrane component [KO:K15771]
ML5_1014  binding-protein-dependent transport systems inner membrane component [KO:K15772]
ML5_4755  extracellular solute-binding protein family 1 [KO:K10117]
ML5_4756  binding-protein-dependent transport systems inner membrane component [KO:K10118]
ML5_4757  binding-protein-dependent transport systems inner membrane component [KO:K10119]
ML5_3269  binding-protein-dependent transport systems inner membrane component [KO:K10233]
ML5_3268  binding-protein-dependent transport systems inner membrane component [KO:K10234]
ML5_4499  extracellular solute-binding protein family 1 [KO:K17318]
ML5_4790  extracellular solute-binding protein family 1 [KO:K17318]
ML5_4501  binding-protein-dependent transport systems inner membrane component [KO:K17319]
ML5_4791  binding-protein-dependent transport systems inner membrane component [KO:K17319]
ML5_4500  binding-protein-dependent transport systems inner membrane component [KO:K17320]
ML5_4792  binding-protein-dependent transport systems inner membrane component [KO:K17320]
ML5_4123  extracellular solute-binding protein family 1 [KO:K10236]
ML5_4124  binding-protein-dependent transport systems inner membrane component [KO:K10237]
ML5_4125  binding-protein-dependent transport systems inner membrane component [KO:K10238]
ML5_4095  extracellular solute-binding protein family 1 [KO:K10200]
ML5_4088  extracellular solute-binding protein family 1 [KO:K10200]
ML5_4096  binding-protein-dependent transport systems inner membrane component [KO:K10201]
ML5_4089  binding-protein-dependent transport systems inner membrane component [KO:K10201]
ML5_4097  binding-protein-dependent transport systems inner membrane component [KO:K10202]
ML5_4090  binding-protein-dependent transport systems inner membrane component [KO:K10202]
ML5_1922  extracellular solute-binding protein family 1 [KO:K10240]
ML5_2811  extracellular solute-binding protein family 1 [KO:K10240]
ML5_4261  extracellular solute-binding protein family 1 [KO:K10240]
ML5_1535  extracellular solute-binding protein family 1 [KO:K10240]
ML5_1536  binding-protein-dependent transport systems inner membrane component [KO:K10241]
ML5_1923  binding-protein-dependent transport systems inner membrane component [KO:K10241]
ML5_2810  binding-protein-dependent transport systems inner membrane component [KO:K10241]
ML5_4260  binding-protein-dependent transport systems inner membrane component [KO:K10241]
ML5_1924  binding-protein-dependent transport systems inner membrane component [KO:K10242]
ML5_2809  binding-protein-dependent transport systems inner membrane component [KO:K10242]
ML5_4259  binding-protein-dependent transport systems inner membrane component [KO:K10242]
ML5_1537  binding-protein-dependent transport systems inner membrane component [KO:K10242]
ML5_3440  extracellular solute-binding protein family 1 [KO:K17329]
ML5_3441  binding-protein-dependent transport systems inner membrane component [KO:K17330]
ML5_3442  binding-protein-dependent transport systems inner membrane component [KO:K17331]
ML5_4715  xylose ABC transporter, substrate-binding protein [KO:K10546]
ML5_4717  inner-membrane translocator [KO:K10547]
ML5_4716  ABC transporter related protein [KO:K10548] [EC:7.5.2.-]
ML5_1017  basic membrane lipoprotein [KO:K07335]
ML5_1019  inner-membrane translocator [KO:K23535]
ML5_1020  inner-membrane translocator [KO:K23536]
ML5_1018  ABC transporter related protein [KO:K23537]
ML5_2068  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
ML5_3512  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
ML5_4289  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
ML5_3511  inner-membrane translocator [KO:K10440]
ML5_4288  inner-membrane translocator [KO:K10440]
ML5_2071  inner-membrane translocator [KO:K10440]
ML5_4287  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
ML5_3510  ABC transporter related protein [KO:K10441] [EC:7.5.2.7]
ML5_4721  periplasmic binding protein/LacI transcriptional regulator [KO:K23508]
ML5_4724  inner-membrane translocator [KO:K23509]
ML5_4723  inner-membrane translocator [KO:K23509]
ML5_4722  ABC transporter related protein [KO:K10820] [EC:7.5.2.9]
ML5_0526  hypothetical protein [KO:K10543]
ML5_0528  inner-membrane translocator [KO:K10544]
ML5_0527  ABC transporter related protein [KO:K10545] [EC:7.5.2.10]
ML5_2773  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
ML5_2772  phosphate ABC transporter, inner membrane subunit PstC [KO:K02037]
ML5_2771  phosphate ABC transporter, inner membrane subunit PstA [KO:K02038]
ML5_2770  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:7.3.2.1]
ML5_1801  extracellular solute-binding protein family 3 [KO:K10005]
ML5_1800  polar amino acid ABC transporter, inner membrane subunit [KO:K10006]
ML5_1799  polar amino acid ABC transporter, inner membrane subunit [KO:K10007]
ML5_1802  ABC transporter related protein [KO:K10008] [EC:7.4.2.1]
ML5_2898  Extracellular ligand-binding receptor [KO:K01999]
ML5_1035  Extracellular ligand-binding receptor [KO:K01999]
ML5_6193  extracellular ligand-binding receptor [KO:K01999]
ML5_3913  Extracellular ligand-binding receptor [KO:K01999]
ML5_0568  Extracellular ligand-binding receptor [KO:K01999]
ML5_4828  Extracellular ligand-binding receptor [KO:K01999]
ML5_0214  Extracellular ligand-binding receptor [KO:K01999]
ML5_2901  inner-membrane translocator [KO:K01997]
ML5_3914  inner-membrane translocator [KO:K01997]
ML5_4826  inner-membrane translocator [KO:K01997]
ML5_2902  inner-membrane translocator [KO:K01998]
ML5_3915  inner-membrane translocator [KO:K01998]
ML5_4827  inner-membrane translocator [KO:K01998]
ML5_2899  ABC transporter related protein [KO:K01995]
ML5_3916  ABC transporter related protein [KO:K01995]
ML5_4824  ABC transporter related protein [KO:K01995]
ML5_2900  ABC transporter related protein [KO:K01996]
ML5_3917  ABC transporter related protein [KO:K01996]
ML5_4825  ABC transporter related protein [KO:K01996]
ML5_0501  extracellular solute-binding protein family 5 [KO:K15580]
ML5_0478  extracellular solute-binding protein family 5 [KO:K15580]
ML5_0500  binding-protein-dependent transport systems inner membrane component [KO:K15581]
ML5_0479  binding-protein-dependent transport systems inner membrane component [KO:K15581]
ML5_0499  binding-protein-dependent transport systems inner membrane component [KO:K15582]
ML5_0480  binding-protein-dependent transport systems inner membrane component [KO:K15582]
ML5_0498  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583]
ML5_0481  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583]
ML5_0497  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823]
ML5_0482  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823]
ML5_2268  periplasmic binding protein [KO:K25286]
ML5_2265  transport system permease protein [KO:K23186]
ML5_2266  transport system permease protein [KO:K23187]
ML5_2267  ABC transporter related protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
ML5_5802  periplasmic binding protein [KO:K23227]
ML5_5801  transport system permease protein [KO:K23228]
ML5_5803  ABC transporter related protein [KO:K10829] [EC:7.2.2.16]
ML5_3478  periplasmic solute binding protein [KO:K09815]
ML5_3476  ABC-3 protein [KO:K09816]
ML5_3477  ABC transporter related protein [KO:K09817] [EC:7.2.2.20]
ML5_1452  hypothetical protein [KO:K02009]
ML5_1451  cobalamin (vitamin B12) biosynthesis CbiM protein [KO:K02007]
ML5_1453  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
ML5_1454  cobalt ABC transporter, ATPase subunit [KO:K02006]
ML5_4486  cobalt transport protein [KO:K16785]
ML5_3466  cobalt transport protein [KO:K16785]
ML5_2190  ABC-2 type transporter [KO:K09692]
ML5_2189  ABC transporter related protein [KO:K09693] [EC:7.5.2.4]
ML5_4491  protein of unknown function DUF214 [KO:K09813]
ML5_4666  protein of unknown function DUF214 [KO:K09813]
ML5_4665  ABC transporter related protein [KO:K09814] [EC:7.6.2.-]
ML5_4492  ABC transporter related protein [KO:K09814] [EC:7.6.2.-]
ML5_1271  protein of unknown function DUF214 [KO:K09811]
ML5_1270  cell division ATP-binding protein FtsE [KO:K09812]
ML5_1066  ABC transporter related protein [KO:K18887]
ML5_1065  ABC transporter transmembrane region [KO:K18888]
ML5_1040  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012]
ML5_1041  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
ML5_3606  ABC transporter related protein [KO:K18230]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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