KEGG   PATHWAY: mna04136
Entry
mna04136                    Pathway                                
Name
Autophagy - other - Miniopterus natalensis (Natal long-fingered bat)
Description
Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mna04136  Autophagy - other
mna04136

Other DBs
GO: 0006914
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107532063  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107533377  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
107524513  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
107530320  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
107528161  ATG101; autophagy-related protein 101 [KO:K19730]
107532903  IGBP1; LOW QUALITY PROTEIN: immunoglobulin-binding protein 1 [KO:K17606]
107525394  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107534103  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107524932  ATG9B; autophagy-related protein 9B [KO:K17907]
107524776  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
107528082  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
107533647  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
107537602  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
107528402  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
107528923  BECN1; beclin-1 [KO:K08334]
107528319  BECN2; beclin-2 [KO:K08334]
107546605  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
107546108  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
107546475  ATG12; LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
107540698  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
107530749  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
107534739  ATG7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
107535031  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
107527438  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
107524724  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107544101  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
107544523  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
107530050  ATG4B; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
107533296  ATG4D; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
107533703  ATG4C; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
107526051  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  Title
Autophagy in protists.
  Journal
Autophagy 7:127-58 (2011)
DOI:10.4161/auto.7.2.13310
Reference
  Authors
Avin-Wittenberg T, Honig A, Galili G
  Title
Variations on a theme: plant autophagy in comparison to yeast and mammals.
  Journal
Protoplasma 249:285-99 (2012)
DOI:10.1007/s00709-011-0296-z
Reference
  Authors
Liu Y, Bassham DC
  Title
Autophagy: pathways for self-eating in plant cells.
  Journal
Annu Rev Plant Biol 63:215-37 (2012)
DOI:10.1146/annurev-arplant-042811-105441
Reference
  Authors
Yoshimoto K
  Title
Beginning to understand autophagy, an intracellular self-degradation system in plants.
  Journal
Plant Cell Physiol 53:1355-65 (2012)
DOI:10.1093/pcp/pcs099
Reference
  Authors
Li F, Chung T, Vierstra RD
  Title
AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  Journal
Plant Cell 26:788-807 (2014)
DOI:10.1105/tpc.113.120014
Reference
  Authors
Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  Title
Autophagy in Plants--What's New on the Menu?
  Journal
Trends Plant Sci 21:134-44 (2016)
DOI:10.1016/j.tplants.2015.10.008
Reference
  Authors
Yang X, Bassham DC
  Title
New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  Journal
Int Rev Cell Mol Biol 320:1-40 (2015)
DOI:10.1016/bs.ircmb.2015.07.005
KO pathway
ko04136   
LinkDB

DBGET integrated database retrieval system