KEGG   PATHWAY: mrh02010
Entry
mrh02010                    Pathway                                
Name
ABC transporters - Mycolicibacterium rhodesiae
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
mrh02010  ABC transporters
mrh02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Mycolicibacterium rhodesiae [GN:mrh]
Gene
MycrhN_4294  sulfate/thiosulfate-binding protein [KO:K23163]
MycrhN_4295  sulfate ABC transporter, permease protein CysT [KO:K02046]
MycrhN_4296  sulfate ABC transporter, permease protein CysW [KO:K02047]
MycrhN_4297  sulfate ABC transporter, ATP-binding protein [KO:K02045] [EC:7.3.2.3]
MycrhN_4304  ABC-type taurine transport system, periplasmic component [KO:K15551]
MycrhN_4305  ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [KO:K15552]
MycrhN_4303  ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [KO:K10831] [EC:7.6.2.7]
MycrhN_2943  ABC transporter, substrate-binding protein, aliphatic sulfonates family [KO:K15553]
MycrhN_5058  ABC transporter, substrate-binding protein, aliphatic sulfonates family [KO:K15553]
MycrhN_2937  ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [KO:K15554]
MycrhN_5060  ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [KO:K15554]
MycrhN_2938  ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [KO:K15555] [EC:7.6.2.14]
MycrhN_5059  ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [KO:K15555] [EC:7.6.2.14]
MycrhN_5565  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
MycrhN_4842  molybdate ABC transporter, permease protein [KO:K02018]
MycrhN_4843  ABC-type sulfate/molybdate transport systems, ATPase component [KO:K02017] [EC:7.3.2.5]
MycrhN_5788  ABC-type Fe3+ transport system, periplasmic component [KO:K02012]
MycrhN_5789  ABC-type Fe3+ transport system, permease component [KO:K02011]
MycrhN_5790  ABC-type spermidine/putrescine transport system, ATPase component [KO:K02010] [EC:7.2.2.7]
MycrhN_5034  spermidine/putrescine-binding periplasmic protein [KO:K11069]
MycrhN_5036  ABC-type spermidine/putrescine transport system, permease component II [KO:K11070]
MycrhN_5035  ABC-type spermidine/putrescine transport system, permease component I [KO:K11071]
MycrhN_5033  spermidine/putrescine ABC transporter ATP-binding subunit [KO:K11072] [EC:7.6.2.11]
MycrhN_1996  periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [KO:K05845]
MycrhN_5075  periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [KO:K05845]
MycrhN_1998  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
MycrhN_1999  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
MycrhN_5076  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
MycrhN_5078  ABC-type proline/glycine betaine transport system, permease component [KO:K05846]
MycrhN_1997  ABC-type proline/glycine betaine transport system, ATPase component [KO:K05847] [EC:7.6.2.9]
MycrhN_5077  ABC-type proline/glycine betaine transport system, ATPase component [KO:K05847] [EC:7.6.2.9]
MycrhN_3284  ATPase component of ABC-type sugar transporter [KO:K10112] [EC:7.5.2.-]
MycrhN_3710  ATPase component of ABC-type sugar transporter [KO:K10112] [EC:7.5.2.-]
MycrhN_3281  ABC-type sugar transport system, periplasmic component [KO:K10227]
MycrhN_3282  permease component of ABC-type sugar transporter [KO:K10228]
MycrhN_3283  ABC-type sugar transport system, permease component [KO:K10229]
MycrhN_3707  ABC-type sugar transport system, periplasmic component [KO:K10236]
MycrhN_3708  permease component of ABC-type sugar transporter [KO:K10237]
MycrhN_3709  ABC-type sugar transport system, permease component [KO:K10238]
MycrhN_4035  virulence factor Mce family protein [KO:K02067]
MycrhN_4036  virulence factor Mce family protein [KO:K02067]
MycrhN_4183  virulence factor Mce family protein [KO:K02067]
MycrhN_4184  virulence factor Mce family protein [KO:K02067]
MycrhN_4185  virulence factor Mce family protein [KO:K02067]
MycrhN_4186  virulence factor Mce family protein [KO:K02067]
MycrhN_4187  virulence factor Mce family protein [KO:K02067]
MycrhN_1145  virulence factor Mce family protein [KO:K02067]
MycrhN_1146  virulence factor Mce family protein [KO:K02067]
MycrhN_2601  virulence factor Mce family protein [KO:K02067]
MycrhN_2602  virulence factor Mce family protein [KO:K02067]
MycrhN_2604  virulence factor Mce family protein [KO:K02067]
MycrhN_2605  virulence factor Mce family protein [KO:K02067]
MycrhN_2606  virulence factor Mce family protein [KO:K02067]
MycrhN_2338  virulence factor Mce family protein [KO:K02067]
MycrhN_2339  virulence factor Mce family protein [KO:K02067]
MycrhN_2341  virulence factor Mce family protein [KO:K02067]
MycrhN_2342  virulence factor Mce family protein [KO:K02067]
MycrhN_3001  virulence factor Mce family protein [KO:K02067]
MycrhN_3002  virulence factor Mce family protein [KO:K02067]
MycrhN_3004  virulence factor Mce family protein [KO:K02067]
MycrhN_3170  virulence factor Mce family protein [KO:K02067]
MycrhN_3172  virulence factor Mce family protein [KO:K02067]
MycrhN_3173  virulence factor Mce family protein [KO:K02067]
MycrhN_1581  virulence factor Mce family protein [KO:K02067]
MycrhN_1582  virulence factor Mce family protein [KO:K02067]
MycrhN_1584  virulence factor Mce family protein [KO:K02067]
MycrhN_1585  virulence factor Mce family protein [KO:K02067]
MycrhN_1586  virulence factor Mce family protein [KO:K02067]
MycrhN_3578  virulence factor Mce family protein [KO:K02067]
MycrhN_3579  virulence factor Mce family protein [KO:K02067]
MycrhN_3580  virulence factor Mce family protein [KO:K02067]
MycrhN_3581  virulence factor Mce family protein [KO:K02067]
MycrhN_3582  virulence factor Mce family protein [KO:K02067]
MycrhN_3583  virulence factor Mce family protein [KO:K02067]
MycrhN_4182  virulence factor Mce family protein [KO:K02067]
MycrhN_2337  virulence factor Mce family protein [KO:K02067]
MycrhN_2340  virulence factor Mce family protein [KO:K02067]
MycrhN_3000  virulence factor Mce family protein [KO:K02067]
MycrhN_3363  virulence factor Mce family protein [KO:K02067]
MycrhN_0010  virulence factor Mce family protein [KO:K02067]
MycrhN_0009  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
MycrhN_2603  virulence factor Mce family protein [KO:K02067]
MycrhN_2526  virulence factor Mce family protein [KO:K02067]
MycrhN_3003  virulence factor Mce family protein [KO:K02067]
MycrhN_2999  virulence factor Mce family protein [KO:K02067]
MycrhN_3169  virulence factor Mce family protein [KO:K02067]
MycrhN_3171  virulence factor Mce family protein [KO:K02067]
MycrhN_3174  virulence factor Mce family protein [KO:K02067]
MycrhN_3362  virulence factor Mce family protein [KO:K02067]
MycrhN_3359  virulence factor Mce family protein [KO:K02067]
MycrhN_3360  virulence factor Mce family protein [KO:K02067]
MycrhN_3361  virulence factor Mce family protein [KO:K02067]
MycrhN_3364  virulence factor Mce family protein [KO:K02067]
MycrhN_1583  virulence factor Mce family protein [KO:K02067]
MycrhN_0006  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
MycrhN_0007  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
MycrhN_0008  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
MycrhN_1144  virulence factor Mce family protein [KO:K02067]
MycrhN_1147  virulence factor Mce family protein [KO:K02067]
MycrhN_1148  virulence factor Mce family protein [KO:K02067]
MycrhN_1149  virulence factor Mce family protein [KO:K02067]
MycrhN_4039  virulence factor Mce family protein [KO:K02067]
MycrhN_4034  virulence factor Mce family protein [KO:K02067]
MycrhN_4037  virulence factor Mce family protein [KO:K02067]
MycrhN_4038  virulence factor Mce family protein [KO:K02067]
MycrhN_0011  ABC-type transport system involved in resistance to organic solvents, periplasmic component [KO:K02067]
MycrhN_2997  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_4032  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_4033  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_4180  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_4181  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_2600  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_2335  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_2336  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_2998  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_1587  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_1588  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_3577  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_3576  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_0013  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_0495  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_3168  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_0012  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_2599  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_3167  ABC-type transport system involved in resistance to organic solvents, permease component [KO:K02066]
MycrhN_0747  ABC-type transport system involved in resistance to organic solvents, ATPase component [KO:K02065]
MycrhN_2570  phosphate ABC transporter, phosphate-binding protein [KO:K02040]
MycrhN_2571  phosphate ABC transporter, permease protein PstC [KO:K02037]
MycrhN_2572  phosphate ABC transporter, permease protein PstA [KO:K02038]
MycrhN_2573  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
MycrhN_0845  amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family [KO:K10036 K10037]
MycrhN_0844  ABC-type polar amino acid transport system, ATPase component [KO:K10038] [EC:7.4.2.1]
MycrhN_5597  periplasmic component of amino acid ABC-type transporter/signal transduction system [KO:K10005]
MycrhN_5598  amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family [KO:K10006]
MycrhN_5599  amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family [KO:K10007]
MycrhN_5596  ABC-type polar amino acid transport system, ATPase component [KO:K10008] [EC:7.4.2.1]
MycrhN_2025  amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family [KO:K02424 K10009]
MycrhN_2024  ABC-type polar amino acid transport system, ATPase component [KO:K10010] [EC:7.4.2.1]
MycrhN_4598  ABC-type branched-chain amino acid transport system, periplasmic component [KO:K01999]
MycrhN_5829  hypothetical protein [KO:K01999]
MycrhN_5839  hypothetical protein [KO:K01999]
MycrhN_4599  branched-chain amino acid ABC-type transport system, permease component [KO:K01997]
MycrhN_4600  ABC-type branched-chain amino acid transport system, permease component [KO:K01998]
MycrhN_4601  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01995]
MycrhN_4602  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01996]
MycrhN_5446  urea ABC transporter, urea binding protein [KO:K11959]
MycrhN_5447  urea ABC transporter, permease protein UrtB [KO:K11960]
MycrhN_5448  urea ABC transporter, permease protein UrtC [KO:K11961]
MycrhN_5449  urea ABC transporter, ATP-binding protein UrtD [KO:K11962]
MycrhN_5450  urea ABC transporter, ATP-binding protein UrtE [KO:K11963]
MycrhN_3764  ABC-type dipeptide transport system, periplasmic component [KO:K13889]
MycrhN_3767  ABC-type dipeptide/oligopeptide/nickel transport system, permease component [KO:K13890]
MycrhN_3766  ABC-type dipeptide/oligopeptide/nickel transport system, permease component [KO:K13891]
MycrhN_3765  oligopeptide/dipeptide ABC transporter, ATP-binding protein [KO:K13892]
MycrhN_4366  ABC-type cobalt transport system, permease component CbiQ [KO:K16785]
MycrhN_1966  ABC-type polysaccharide/polyol phosphate export systems, permease component [KO:K09690]
MycrhN_1968  ABC-type polysaccharide/polyol phosphate transport system, ATPase component [KO:K09691] [EC:7.5.2.14]
MycrhN_0217  cell division protein [KO:K09811]
MycrhN_0218  cell division ATP-binding protein FtsE [KO:K09812]
MycrhN_4327  ABC-type multidrug transport system, ATPase and permease component [KO:K14698] [EC:7.-.-.-]
MycrhN_4326  ABC-type multidrug transport system, ATPase and permease component [KO:K14699] [EC:7.-.-.-]
MycrhN_3752  ABC-type multidrug transport system, ATPase and permease component [KO:K18887]
MycrhN_4582  fused ATPase/permease component of ABC-type transporter involved in cytochrome bd biogenesis [KO:K16012]
MycrhN_4583  cysteine export CydDC family ABC transporter permease subunit/ATP-binding protein CydD [KO:K16013]
MycrhN_4806  ABC-type uncharacterized transport system, permease and ATPase component [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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