Entry
Name
ABC transporters - Mycolicibacterium smegmatis MC2 155
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
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Other DBs
Organism
Mycolicibacterium smegmatis MC2 155 [GN:
msg ]
Gene
MSMEI_4419 Sulfate-transport integral membrane protein ABC transporter CysT [KO:K02046 ]
MSMEI_4418 Sulfate-transport integral membrane protein ABC transporter CysW [KO:K02047 ]
MSMEI_0110 Substrate-binding region of ABC-type glycine betaine transport system [KO:K15551 ]
MSMEI_0109 Binding-protein-dependent transport systems inner membrane component [KO:K15552 ]
MSMEI_5377 Aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
MSMEI_0535 Aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
MSMEI_3761 Aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
MSMEI_1197 Nitrate ABC transporter, periplasmic nitrate-binding protein, putative (Putative ABC-type nitrate/sulfonate/bicarbonate transport system periplasmic component) [KO:K15553 ]
MSMEI_0534 Binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
MSMEI_4476 Binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
MSMEI_5378 Binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
MSMEI_1198 Binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
MSMEI_1971 modA; Molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
MSMEI_3550 Binding-protein-dependent transport systems inner membrane component [KO:K02011 ]
MSMEI_0641 Binding-protein-dependent transport systems inner membrane component [KO:K11070 ]
MSMEI_5030 Putative ABC-type proline/glycine betaine transport protein [KO:K02002 ]
MSMEI_2851 Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 ]
MSMEI_6168 proX; Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 ]
MSMEI_2852 Binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
MSMEI_6165 proZ; Binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
MSMEI_6166 proW; Binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
MSMEI_6167 proV; Osmoprotectant (Glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter proV [KO:K05847 ] [EC:7.6.2.9 ]
MSMEI_4931 sugC; Sugar-transport ATP-binding protein ABC transporter sugC [KO:K10112 ] [EC:7.5.2.-]
MSMEI_0505 ATP-binding protein of sugar ABC transporter [KO:K10112 ] [EC:7.5.2.-]
MSMEI_5015 Binding-protein-dependent transport systems inner membrane component [KO:K10119 ]
MSMEI_4932 sugB; Sugar-transport integral membrane protein ABC transporter SugB [KO:K10238 ]
MSMEI_3907 Putative sugar ABC transporter, periplasmic sugar-binding protein [KO:K23545 ]
MSMEI_1110 yrbE3B; Conserved hypothetical integral membrane protein YrbE6B [KO:K02066 ]
MSMEI_0129 yrbE1A; conserved hypothetical integral membrane protein Yrbe1a [KO:K02066 ]
MSMEI_0130 yrbE1B; conserved hypothetical integral membrane protein Yrbe1b [KO:K02066 ]
MSMEI_5741 yrbE4B; conserved hypothetical integral membrane protein Yrbe1b [KO:K02066 ]
MSMEI_1327 mkl; Ribonucleotide ABC transporter ATP-binding protein Mkl [KO:K02065 ]
MSMEI_3516 Periplasmic binding protein/LacI transcriptional regulator [KO:K10439 ]
MSMEI_3515 ABC transporter, carbohydrate uptake transporter-2 (CUT2) family, periplasmic sugar-binding protein [KO:K10439 ]
MSMEI_1335 Putative ribose ABC transporter, periplasmic D-ribose-bindingprotein [KO:K10439 ]
MSMEI_3018 Periplasmic binding protein/LacI transcriptional regulator [KO:K10439 ]
MSMEI_1672 Periplasmic binding protein/LacI transcriptional regulator [KO:K23508 ]
MSMEI_5860 Periplasmic binding protein/LacI transcriptional regulator [KO:K10543 ]
MSMEI_6622 Periplasmic binding protein/LacI transcriptional regulator [KO:K10552 ]
MSMEI_5628 pstC2; Phosphate-transport integral membrane ABC transporter PstC2 [KO:K02037 ]
MSMEI_6697 ABC-type branched-chain amino acid transport system, permease protein I [KO:K01997 ]
MSMEI_6696 Branched-chain amino acid ABC transporter permease protein [KO:K01998 ]
MSMEI_1183 Branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995 ]
MSMEI_1182 Branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996 ]
MSMEI_6694 Branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996 ]
MSMEI_5651 Binding-protein-dependent transport systems inner membrane component [KO:K02072 ]
MSMEI_5194 ABC-type branched-chain amino acid transport system, periplasmic component [KO:K11959 ]
MSMEI_2906 Branched-chain amino acid ABC transporter permease protein [KO:K11960 ]
MSMEI_2905 Branched-chain amino acid ABC transporter permease protein [KO:K11961 ]
MSMEI_2904 ABC branched-chain amino acid transporter, ATP-binding component [KO:K11962 ]
MSMEI_4868 Oligopeptide-transport integral membrane protein ABC transporter OppB [KO:K13890 ]
MSMEI_0015 Ferric enterobactin ABC transporter, permease protein FepG [KO:K23187 ]
MSMEI_6200 rfbD; O-antigen/lipopolysaccharide ABC transporter permease protein RfbD [KO:K09690 ]
MSMEI_1468 Antibiotic-transport integral membrane leucine, alanine and valine rich protein ABC transporter [KO:K16905 ]
MSMEI_1467 putative antibiotic-transport integral membrane leucine and valine rich protein ABC transporter [KO:K16906 ]
MSMEI_1466 putative antibiotic-transport ATP-binding protein ABC transporter [KO:K16907 ] [EC:7.6.2.-]
MSMEI_6377 Transmembrane ATP-binding protein ABC transporter [KO:K14698 ] [EC:7.-.-.-]
MSMEI_6376 Transmembrane ATP-binding protein ABC transporter [KO:K14699 ] [EC:7.-.-.-]
MSMEI_3148 cydC; Component linked with the assembly of cytochrome' ABC transporter ATP-binding protein CydC [KO:K16012 ]
MSMEI_3149 cydD; Transmembrane ATP-binding protein ABC transporter cydD [KO:K16013 ]
MSMEI_3569 Drug-transport transmembrane ATP-binding protein ABC transporter [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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