Entry Name ABC transporters - Mycolicibacterium smegmatis MC2 155
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Mycolicibacterium smegmatis MC2 155 [GN:
msg ]
Gene MSMEI_0129 yrbE1A; conserved hypothetical integral membrane protein Yrbe1a [KO:K02066 ]
MSMEI_0130 yrbE1B; conserved hypothetical integral membrane protein Yrbe1b [KO:K02066 ]
MSMEI_1110 yrbE3B; Conserved hypothetical integral membrane protein YrbE6B [KO:K02066 ]
MSMEI_1327 mkl; Ribonucleotide ABC transporter ATP-binding protein Mkl [KO:K02065 ]
MSMEI_1971 modA; Molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
MSMEI_3148 cydC; Component linked with the assembly of cytochrome' ABC transporter ATP-binding protein CydC [KO:K16012 ]
MSMEI_3149 cydD; Transmembrane ATP-binding protein ABC transporter cydD [KO:K16013 ]
MSMEI_4931 sugC; Sugar-transport ATP-binding protein ABC transporter sugC [KO:K10112 ] [EC:7.5.2.-]
MSMEI_4932 sugB; Sugar-transport integral membrane protein ABC transporter SugB [KO:K10238 ]
MSMEI_5628 pstC2; Phosphate-transport integral membrane ABC transporter PstC2 [KO:K02037 ]
MSMEI_5741 yrbE4B; conserved hypothetical integral membrane protein Yrbe1b [KO:K02066 ]
MSMEI_6165 proZ; Binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
MSMEI_6166 proW; Binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
MSMEI_6167 proV; Osmoprotectant (Glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter proV [KO:K05847 ] [EC:7.6.2.9 ]
MSMEI_6168 proX; Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 ]
MSMEI_6200 rfbD; O-antigen/lipopolysaccharide ABC transporter permease protein RfbD [KO:K09690 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
