KEGG   PATHWAY: mshj05152
Entry
mshj05152                   Pathway                                
Name
Tuberculosis - Mycobacterium shinjukuense
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mshj05152  Tuberculosis
mshj05152

Organism
Mycobacterium shinjukuense [GN:mshj]
Gene
MSHI_34310  hypothetical protein [KO:K14952]
MSHI_26910  lpqH_1; lipoprotein [KO:K14953]
MSHI_33760  lpqH_2; lipoprotein LpqH [KO:K14953]
MSHI_18000  lprG; lipoarabinomannan carrier protein LprG [KO:K14954]
MSHI_04720  lprA_1; lipoprotein LprA [KO:K14955]
MSHI_04780  lprA_2; lipoprotein LprA [KO:K14955]
MSHI_25460  pstS2_2; phosphate-binding protein PstS 3 [KO:K02040]
MSHI_01050  pstS3; phosphate-binding protein PstS 3 [KO:K02040]
MSHI_01090  pstS2_1; phosphate-binding protein PstS [KO:K02040]
MSHI_31260  dnaK; chaperone protein DnaK [KO:K04043]
MSHI_26510  groEL1; 60 kDa chaperonin 1 [KO:K04077] [EC:5.6.1.7]
MSHI_29990  groL2; 60 kDa chaperonin 2 [KO:K04077] [EC:5.6.1.7]
MSHI_30950  esxA_1; 6 kDa early secretory antigenic target [KO:K14956]
MSHI_34750  esxA_2; 6 kDa early secretory antigenic target [KO:K14956]
MSHI_31910  esxR_2; ESAT-6-like protein EsxR [KO:K14956]
MSHI_26710  esxT; ESAT-6-like protein EsxT [KO:K14956]
MSHI_26720  esxU; ESAT-6-like protein EsxU [KO:K14956]
MSHI_30940  esxB_1; ESAT-6-like protein EsxB [KO:K14956]
MSHI_34910  esxC; ESAT-6-like protein EsxC [KO:K14956]
MSHI_34920  esxD; EsxD [KO:K14956]
MSHI_35100  esxF; ESAT-6-like protein EsxF [KO:K14956]
MSHI_08530  esxP; ESAT-6-like protein EsxP [KO:K14956]
MSHI_00130  esxN_1; ESAT-6-like protein EsxN [KO:K14956]
MSHI_31920  esxG; type VII secretion system protein EsxS [KO:K14956]
MSHI_02390  esxN_2; ESAT-6-like protein EsxN [KO:K14956]
MSHI_02400  esxJ_1; ESAT-6-like protein EsxJ [KO:K14956]
MSHI_08540  esxN_3; ESAT-6-like protein EsxN [KO:K14956]
MSHI_35090  esxE; ESAT-6-like protein EsxE [KO:K14956]
MSHI_06620  esxS; type VII secretion system protein EsxS [KO:K14956]
MSHI_06630  esxR_1; ESAT-6-like protein EsxR [KO:K14956]
MSHI_08620  esxJ_2; ESAT-6-like protein EsxJ [KO:K14956]
MSHI_08630  esxN_4; ESAT-6-like protein EsxN [KO:K14956]
MSHI_14000  esxN_5; ESAT-6-like protein EsxN [KO:K14956]
MSHI_14010  esxJ_3; ESAT-6-like protein EsxJ [KO:K14956]
MSHI_34740  esxB_2; ESAT-6-like protein EsxB [KO:K14956]
MSHI_38030  esxJ_4; ESAT-6-like protein EsxJ [KO:K14956]
MSHI_38040  esxN_6; ESAT-6-like protein EsxN [KO:K14956]
MSHI_41110  esxN_7; ESAT-6-like protein EsxN [KO:K14956]
MSHI_25610  acid phosphatase [KO:K21302] [EC:3.1.3.64]
MSHI_30460  pknG; serine/threonine-protein kinase PknG [KO:K14949] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
mshj00571  Lipoarabinomannan (LAM) biosynthesis
KO pathway
ko05152   
LinkDB

DBGET integrated database retrieval system