KEGG   PATHWAY: mtn05152
Entry
mtn05152                    Pathway                                
Name
Tuberculosis - Mycobacterium tuberculosis Erdman = ATCC 35801
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mtn05152  Tuberculosis
mtn05152

Organism
Mycobacterium tuberculosis Erdman = ATCC 35801 [GN:mtn]
Gene
ERDMAN_4185  hypothetical protein [KO:K14952]
ERDMAN_4124  lpqH; 19 kDa lipoprotein antigen precursor [KO:K14953]
ERDMAN_1570  lprG; lipoprotein [KO:K14954]
ERDMAN_1419  lprA; lipoprotein [KO:K14955]
ERDMAN_1029  pstS3; periplasmic phosphate-binding lipoprotein [KO:K02040]
ERDMAN_1033  pstS2; periplasmic phosphate-binding lipoprotein [KO:K02040]
ERDMAN_1035  pstS1; periplasmic phosphate-binding lipoprotein [KO:K02040]
ERDMAN_0389  dnaK; molecular chaperone [KO:K04043]
ERDMAN_0483  groEL; chaperonin [KO:K04077] [EC:5.6.1.7]
ERDMAN_3738  groEL; chaperonin [KO:K04077] [EC:5.6.1.7]
ERDMAN_4249  esxA; 6 kDa early secretory antigenic target ESXA [KO:K14956]
ERDMAN_0322  esxH; low molecular weight protein antigen 7 [KO:K14956]
ERDMAN_1983  esxN; putative ESAT-6 like protein [KO:K14956]
ERDMAN_3772  esxT; putative ESAT-6 like protein [KO:K14956]
ERDMAN_3773  esxU; ESAT-6 like protein [KO:K14956]
ERDMAN_4248  esxB; 10 kDa culture filtrate antigen [KO:K14956]
ERDMAN_4269  esxC; ESAT-6 like protein [KO:K14956]
ERDMAN_4270  esxD; ESAT-6 like protein [KO:K14956]
ERDMAN_4284  esxF; hypothetical protein [KO:K14956]
ERDMAN_2576  esxO; putative ESAT-6 like protein [KO:K14956]
ERDMAN_2577  esxP; putative ESAT-6 like protein [KO:K14956]
ERDMAN_3306  esxQ; ESAT-6 like protein [KO:K14956]
ERDMAN_3964  esxW; putative ESAT-6 like protein [KO:K14956]
ERDMAN_0321  esxG; hypothetical protein [KO:K14956]
ERDMAN_1155  esxV; putative ESAT-6 like protein [KO:K14956]
ERDMAN_1156  esxJ; ESAT-6 like protein [KO:K14956]
ERDMAN_1340  esxK; ESAT-6 like protein [KO:K14956]
ERDMAN_1341  esxL; putative ESAT-6 like protein [KO:K14956]
ERDMAN_4283  esxE; hypothetical protein [KO:K14956]
ERDMAN_3626  acid phosphatase [KO:K21302] [EC:3.1.3.64]
ERDMAN_0452  pknG; serine/threonine-protein kinase [KO:K14949] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
mtn00571  Lipoarabinomannan (LAM) biosynthesis
KO pathway
ko05152   
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