Entry Name ABC transporters - Mycobacterium tuberculosis H37Rv
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mycobacterium tuberculosis H37Rv [GN:
mtv ]
Gene RVBD_2399c sulfate-transport ABC transporter integral membrane protein CysT [KO:K02046 ]
RVBD_2398c sulfate-transport ABC transporter integral membrane protein CysW [KO:K02047 ]
RVBD_1857 molybdenum-transport ABC transporter molybdate-binding lipoprotein ModA [KO:K02020 ]
RVBD_1858 molybdenum-transport ABC transporter integral membrane protein ModB [KO:K02018 ]
RVBD_3756c osmoprotectant-transport ABC transporter integral membrane protein ProZ [KO:K05846 ]
RVBD_3757c osmoprotectant-transport ABC transporter integral membrane protein ProW [KO:K05846 ]
RVBD_1238 sugar-transport ABC transporter ATP-binding protein [KO:K10112 ] [EC:7.5.2.-]
RVBD_1236 sugar-transport ABC transporter integral membrane protein SugA [KO:K10237 ]
RVBD_1237 sugar-transport ABC transporter integral membrane protein SugB [KO:K10238 ]
RVBD_0655 ribonucleotide-transport ABC transporter ATP-binding protein Mkl [KO:K02065 ]
RVBD_2833c sn-glycerol-3-phosphate transport ABC transporter sn-glycerol-3-phosphate-binding lipoprotein UgpB [KO:K05813 ]
RVBD_2835c sn-glycerol-3-phosphate transport ABC transporter integral membrane protein UgpA [KO:K05814 ]
RVBD_2834c sn-glycerol-3-phosphate transport ABC transporter integral membrane protein UgpE [KO:K05815 ]
RVBD_0929 phosphate-transport ABC transporter integral membrane protein PstC2 [KO:K02037 ]
RVBD_0935 phosphate-transport ABC transporter integral membrane protein PstC1 [KO:K02037 ]
RVBD_0930 phosphate-transport ABC transporter integral membrane protein PstA1 [KO:K02038 ]
RVBD_0936 phosphate-transport ABC transporter integral membrane protein PstA2 [KO:K02038 ]
RVBD_3665c dipeptide-transport ABC transporter integral membrane protein DppB [KO:K15581 ]
RVBD_3664c dipeptide-transport ABC transporter integral membrane protein DppC [KO:K15582 ]
RVBD_1283c oligopeptide-transport ABC transporter integral membrane protein OppB [KO:K13890 ]
RVBD_1282c oligopeptide-transport ABC transporter integral membrane protein OppC [KO:K13891 ]
RVBD_1281c oligopeptide-transport ABC transporter ATP-binding protein OppD [KO:K13892 ]
RVBD_3783 O-antigen/lipopolysaccharide-transport ABC transporter integral membrane protein RfbD [KO:K09690 ]
RVBD_3781 O-antigen/lipopolysaccharide transport ABC transporter ATP-binding protein RfbE [KO:K09691 ] [EC:7.5.2.14 ]
RVBD_1819c drug-transport transmembrane ABC transporter ATP-binding protein BacA [KO:K02471 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
