KEGG PATHWAY: mwa03440

KEGG

PATHWAY: mwa03440

Entry

mwa03440                    Pathway

Name

Homologous recombination - Microbacterium wangchenii

Description

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Class

Genetic Information Processing; Replication and repair

Pathway map

Homologous recombination

Other DBs

GO:

Organism

Microbacterium wangchenii [GN:mwa]

Gene

single-stranded DNA-binding protein [KO:K03111]

ssb; single-stranded DNA-binding protein [KO:K03111]

single-stranded DNA-binding protein [KO:K03111]

single-stranded DNA-binding protein [KO:K03111]

recF; DNA replication/repair protein RecF [KO:K03629]

recO; DNA repair protein RecO [KO:K03584]

recR; recombination protein RecR [KO:K06187]

recA; recombinase RecA [KO:K03553]

polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]

ruvA; Holliday junction branch migration protein RuvA [KO:K03550]

ruvB; Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]

ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]

ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]

hypothetical protein [KO:K03581] [EC:3.1.11.5]

dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]

DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]

DNA polymerase III subunit gamma and tau [KO:K02343] [EC:2.7.7.7]

DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]

DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]

3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]

DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]

primosomal protein N' [KO:K04066] [EC:5.6.2.4]

Reference

Authors

Maloisel L, Fabre F, Gangloff S.

Title

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.

Journal

Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07

Reference

Authors

Haruta-Takahashi N, Iwasaki H.

Title

[Recombination mediators]

Journal

Seikagaku 79:449-53 (2007)

Reference

Authors

Ouyang KJ, Woo LL, Ellis NA.

Title

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.

Journal

Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003

Reference

Authors

Kawabata M, Kawabata T, Nishibori M.

Title

Role of recA/RAD51 family proteins in mammals.

Journal

Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987

Reference

Authors

Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.

Title

Mitotic recombination in Saccharomyces cerevisiae.

Journal

Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3

Reference

Authors

Heyer WD, Li X, Rolfsmeier M, Zhang XP.

Title

Rad54: the Swiss Army knife of homologous recombination?

Journal

Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481

Reference

Authors

Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.

Title

Recombination proteins and rescue of arrested replication forks.

Journal

DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016

KO pathway

LinkDB

DBGET integrated database retrieval system