KEGG   PATHWAY: ko03440
Entry
ko03440                     Pathway                                
Name
Homologous recombination
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ko03440  Homologous recombination
ko03440

Other DBs
GO: 0000724
Orthology
K01159  ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
K02317  dnaT; DNA replication protein DnaT
K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328  POLD2; DNA polymerase delta subunit 2
K02335  polA; DNA polymerase I [EC:2.7.7.7]
K02337  dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
K02338  dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
K02339  holC; DNA polymerase III subunit chi [EC:2.7.7.7]
K02340  holA; DNA polymerase III subunit delta [EC:2.7.7.7]
K02341  holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
K02342  dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
K02343  dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
K02344  holD; DNA polymerase III subunit psi [EC:2.7.7.7]
K02345  holE; DNA polymerase III subunit theta [EC:2.7.7.7]
K02686  priB; primosomal replication protein N
K03111  ssb; single-strand DNA-binding protein
K03165  TOP3; DNA topoisomerase III [EC:5.6.2.1]
K03504  POLD3; DNA polymerase delta subunit 3
K03505  POLD4; DNA polymerase delta subunit 4
K03550  ruvA; holliday junction DNA helicase RuvA
K03551  ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
K03553  recA; recombination protein RecA
K03581  recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
K03582  recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
K03583  recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
K03584  recO; DNA repair protein RecO (recombination protein O)
K03629  recF; DNA replication and repair protein RecF
K03655  recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
K03763  polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
K04066  priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
K04067  priC; primosomal replication protein N''
K04482  RAD51; DNA repair protein RAD51
K04728  ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
K06187  recR; recombination protein RecR
K07462  recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
K07466  RFA1, RPA1, rpa; replication factor A1
K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
K08991  MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K10683  BARD1; BRCA1-associated RING domain protein 1
K10728  TOPBP1; topoisomerase (DNA) II binding protein 1
K10739  RFA2, RPA2; replication factor A2
K10740  RPA3; replication factor A3
K10741  RPA4; replication factor A4
K10865  MRE11; double-strand break repair protein MRE11
K10866  RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
K10867  NBN, NBS1; nibrin
K10868  XRS2; DNA repair protein XRS2
K10869  RAD51L1, RAD51B; RAD51-like protein 1
K10870  RAD51L2, RAD51C; RAD51-like protein 2
K10871  RAD51L3, RAD51D; RAD51-like protein 3
K10873  RAD52; DNA repair and recombination protein RAD52
K10875  RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
K10877  RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
K10879  XRCC2; DNA-repair protein XRCC2
K10880  XRCC3; DNA-repair protein XRCC3
K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K10882  EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
K10897  PALB2, FANCN; partner and localizer of BRCA2
K10901  BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
K10957  RAD55; DNA repair protein RAD55
K10958  RAD57; DNA repair protein RAD57
K10959  RAD59; DNA repair protein RAD59
K11864  BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
K14159  rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]
K19528  SYCP3; synaptonemal complex protein 3
K20773  RBBP8, CTIP; DNA endonuclease RBBP8 [EC:3.1.-.-]
K20774  FAM175A, ABRA1; BRCA1-A complex subunit Abraxas
K20775  UIMC1, RAP80; BRCA1-A complex subunit RAP80
K20776  BABAM, NBA1, MERIT40; BRISC and BRCA1-A complex member 1
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016

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