KEGG   PATHWAY: nta00908
Entry
nta00908                    Pathway                                
Name
Zeatin biosynthesis - Nicotiana tabacum (common tobacco)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
nta00908  Zeatin biosynthesis
nta00908

Other DBs
GO: 0009691
Organism
Nicotiana tabacum (common tobacco) [GN:nta]
Gene
107781850  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107816040  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107766196  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107814501  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107821104  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107760037  adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107795022  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107818758  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107811981  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107805874  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107766411  cytokinin hydroxylase-like [KO:K10717]
107810781  cytokinin hydroxylase-like [KO:K10717]
107767396  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
107800769  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107786307  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
107799019  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107800706  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
107778197  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107814889  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
107801329  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
107790677  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
107816221  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
107817189  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
107793379  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107791003  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
107818107  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
107770228  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
107789576  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
107795159  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107778097  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
107759110  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107824610  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
107766515  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
107761609  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
107761611  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107766511  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
107814959  NtGT4; UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107814969  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107819295  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
107782133  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
107820638  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
107820976  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
107777316  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107795998  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107810448  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107790576  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107808866  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107780615  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107793755  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107796877  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107825739  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107827742  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107801620  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107769776  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107824556  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107773195  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107762671  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107813049  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107832357  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107783970  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107798741  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107777483  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107788645  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107788648  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107768192  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107826712  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107821474  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107788105  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107788106  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107788121  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107795312  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107795315  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107795317  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107775337  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107832411  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107806667  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107815118  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107815610  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107779041  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107762674  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107831740  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107759941  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
nta00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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