KEGG   PATHWAY: nta03050
Entry
nta03050                    Pathway                                
Name
Proteasome - Nicotiana tabacum (common tobacco)
Description
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
nta03050  Proteasome
nta03050

Other DBs
GO: 0000502
Organism
Nicotiana tabacum (common tobacco) [GN:nta]
Gene
107767362  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107767363  21D7; probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107812249  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107812252  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107809945  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107814298  probable 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107800024  26S proteasome non-ATPase regulatory subunit 9-like [KO:K06693]
107826660  26S proteasome non-ATPase regulatory subunit 9-like [KO:K06693]
107808467  26S proteasome non-ATPase regulatory subunit 12 homolog A-like [KO:K03035]
107832668  26S proteasome non-ATPase regulatory subunit 12 homolog A-like [KO:K03035]
107803854  26S proteasome non-ATPase regulatory subunit 12 homolog A-like [KO:K03035]
107829204  26S proteasome non-ATPase regulatory subunit 12 homolog A-like [KO:K03035]
107786727  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
107807364  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
107815473  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
107805482  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
107807153  26S proteasome non-ATPase regulatory subunit 6 homolog [KO:K03037]
107819413  26S proteasome non-ATPase regulatory subunit 6 homolog [KO:K03037]
107816075  26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
107805666  26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
107822910  26S proteasome non-ATPase regulatory subunit 13 homolog B-like [KO:K03039]
107779673  26S proteasome non-ATPase regulatory subunit 13 homolog B-like [KO:K03039]
107806446  26S proteasome non-ATPase regulatory subunit 13 homolog B-like [KO:K03039]
107817768  26S proteasome non-ATPase regulatory subunit 13 homolog B-like [KO:K03039]
107783713  26S proteasome non-ATPase regulatory subunit 13 homolog B [KO:K03039]
107790582  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
107800697  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
107762432  26S proteasome non-ATPase regulatory subunit 8 homolog A-like [KO:K03031]
107813385  26S proteasome non-ATPase regulatory subunit 8 homolog A-like [KO:K03031]
107762302  26S proteasome non-ATPase regulatory subunit 8 homolog A-like [KO:K03031]
107809911  26S proteasome non-ATPase regulatory subunit 8 homolog A-like [KO:K03031]
107785623  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
107797238  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
107824255  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
107772378  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
107770355  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
107808066  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
107821749  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
107798338  26S proteasome non-ATPase regulatory subunit 4 homolog [KO:K03029]
107789750  26S proteasome non-ATPase regulatory subunit 2 homolog A-like [KO:K03028]
107794282  26S proteasome non-ATPase regulatory subunit 2 homolog A-like [KO:K03028]
107820776  26S proteasome non-ATPase regulatory subunit 2 homolog A-like [KO:K03028]
107790251  26S proteasome non-ATPase regulatory subunit 2 homolog A-like [KO:K03028]
107812562  26S proteasome non-ATPase regulatory subunit 2 homolog A-like [KO:K03028]
107808390  26S proteasome non-ATPase regulatory subunit 1 homolog A-like [KO:K03032]
107804491  26S proteasome non-ATPase regulatory subunit 1 homolog A-like [KO:K03032]
107783497  26S proteasome non-ATPase regulatory subunit 1 homolog A-like [KO:K03032]
107800592  26S proteasome regulatory subunit RPN13-like [KO:K06691]
107806049  26S proteasome regulatory subunit RPN13-like [KO:K06691]
107812149  26S protease regulatory subunit 7 homolog A-like [KO:K03061]
107812550  26S protease regulatory subunit 7 homolog A-like [KO:K03061]
107790702  26S protease regulatory subunit 7 homolog A-like [KO:K03061]
107807071  26S protease regulatory subunit 7 homolog A-like [KO:K03061]
107788960  26S protease regulatory subunit 7 homolog A [KO:K03061]
107789506  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
107779199  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
107760308  26S proteasome regulatory subunit 4 homolog A-like [KO:K03062]
107819147  26S proteasome regulatory subunit 4 homolog A-like [KO:K03062]
107816419  26S protease regulatory subunit 8 homolog A-like [KO:K03066]
107831822  26S protease regulatory subunit 8 homolog A [KO:K03066]
107812523  26S protease regulatory subunit 8 homolog A-like [KO:K03066]
107785983  RPT6; 26S protease regulatory subunit 8 homolog A-like [KO:K03066]
107767815  26S protease regulatory subunit S10B homolog B-like [KO:K03064]
107785094  26S protease regulatory subunit S10B homolog B-like [KO:K03064]
107765194  26S protease regulatory subunit S10B homolog B-like [KO:K03064]
107815805  26S protease regulatory subunit S10B homolog B-like [KO:K03064]
107783234  26S protease regulatory subunit S10B homolog B-like [KO:K03064]
107761373  26S protease regulatory subunit 10B homolog A [KO:K03064]
107827589  26S protease regulatory subunit 6A homolog [KO:K03065]
107800555  26S protease regulatory subunit 6A homolog [KO:K03065]
107782228  TBP1; 26S protease regulatory subunit 6A homolog [KO:K03065]
107803920  26S protease regulatory subunit 6A homolog [KO:K03065]
107807278  26S protease regulatory subunit 6B homolog [KO:K03063]
107770439  26S protease regulatory subunit 6B homolog [KO:K03063]
107809414  26S protease regulatory subunit 6B homolog [KO:K03063]
107827877  26S protease regulatory subunit 6B homolog [KO:K03063]
107770176  26S protease regulatory subunit 6B homolog [KO:K03063]
107791257  26S protease regulatory subunit 6B homolog [KO:K03063]
107829807  proteasome activator subunit 4-like [KO:K06699]
107782113  proteasome activator subunit 4 [KO:K06699]
107824016  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
107815705  PAA1; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
107823755  proteasome subunit alpha type-2-B-like [KO:K02726] [EC:3.4.25.1]
107789536  proteasome subunit alpha type-2-B [KO:K02726] [EC:3.4.25.1]
107796873  proteasome subunit alpha type-2-A [KO:K02726] [EC:3.4.25.1]
107793517  proteasome subunit alpha type-2-A [KO:K02726] [EC:3.4.25.1]
107768309  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
107789018  a3; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
107816410  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
107815406  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
107814160  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
107782966  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
107800739  a4; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
107823402  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
107803419  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
107807090  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
107783032  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107805979  a5; proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107805624  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107806762  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107817032  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107785901  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
107814220  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107799456  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
107786955  proteasome subunit alpha type-1-A-like [KO:K02725] [EC:3.4.25.1]
107822157  proteasome subunit alpha type-1-B-like [KO:K02725] [EC:3.4.25.1]
107799726  proteasome subunit alpha type-1-A-like [KO:K02725] [EC:3.4.25.1]
107819554  a6; proteasome subunit alpha type-1-B [KO:K02725] [EC:3.4.25.1]
107781489  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
107832196  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
107786909  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
107809579  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
107815086  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
107803244  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107830275  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107772964  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107810801  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107781217  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107778088  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
107777055  proteasome subunit beta type-7-A-like [KO:K02739] [EC:3.4.25.1]
107787670  proteasome subunit beta type-7-A [KO:K02739] [EC:3.4.25.1]
107762226  proteasome subunit beta type-7-A-like [KO:K02739] [EC:3.4.25.1]
107778362  b2; proteasome subunit beta type-7-A-like [KO:K02739] [EC:3.4.25.1]
107830087  proteasome subunit beta type-7-B-like [KO:K02739] [EC:3.4.25.1]
107810939  proteasome subunit beta type-3-A-like [KO:K02735] [EC:3.4.25.1]
107826949  b3; proteasome subunit beta type-3-A-like [KO:K02735] [EC:3.4.25.1]
107776809  proteasome subunit beta type-3-A [KO:K02735] [EC:3.4.25.1]
107817251  proteasome subunit beta type-3-A-like [KO:K02735] [EC:3.4.25.1]
107794572  b4; proteasome subunit beta type-2-A [KO:K02734] [EC:3.4.25.1]
107776568  proteasome subunit beta type-2-A [KO:K02734] [EC:3.4.25.1]
107831212  proteasome subunit beta type-5-like [KO:K02737] [EC:3.4.25.1]
107817858  proteasome subunit beta type-5-like [KO:K02737] [EC:3.4.25.1]
107826209  proteasome subunit beta type-5-like [KO:K02737] [EC:3.4.25.1]
107798450  b5; proteasome subunit beta type-5-like [KO:K02737] [EC:3.4.25.1]
107764037  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
107771299  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
107774588  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
107798889  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
107774109  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
107810770  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
107796267  proteasome subunit beta type-4-like [KO:K02736] [EC:3.4.25.1]
107830555  proteasome subunit beta type-4-like [KO:K02736] [EC:3.4.25.1]
107785082  b7; proteasome subunit beta type-4-like [KO:K02736] [EC:3.4.25.1]
107825913  proteasome subunit beta type-4-like [KO:K02736] [EC:3.4.25.1]
107825043  probable proteasome inhibitor [KO:K06700]
107821577  probable proteasome inhibitor [KO:K06700]
107786032  cyclin-B1-2-like [KO:K11599]
107766475  cyclin-B1-2-like [KO:K11599]
107772088  cyclin-B1-2-like [KO:K11599]
107824349  cyclin-B1-2-like [KO:K11599]
Reference
PMID:16338359
  Authors
Hirano Y, Murata S, Tanaka K
  Title
Large- and small-scale purification of mammalian 26S proteasomes.
  Journal
Methods Enzymol 399:227-40 (2005)
DOI:10.1016/S0076-6879(05)99015-0
Reference
PMID:18497808
  Authors
Saeki Y, Tanaka K
  Title
Cell biology: two hands for degradation.
  Journal
Nature 453:460-1 (2008)
DOI:10.1038/453460a
Reference
PMID:16919475
  Authors
Smith DM, Benaroudj N, Goldberg A
  Title
Proteasomes and their associated ATPases: a destructive combination.
  Journal
J Struct Biol 156:72-83 (2006)
DOI:10.1016/j.jsb.2006.04.012
Reference
PMID:16181324
  Authors
Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  Title
Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  Journal
Immunol Rev 207:19-30 (2005)
DOI:10.1111/j.0105-2896.2005.00308.x
Reference
PMID:19483713
  Authors
Darwin KH
  Title
Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
  Journal
Nat Rev Microbiol 7:485-91 (2009)
DOI:10.1038/nrmicro2148
Reference
PMID:23495936
  Authors
Tomko RJ Jr, Hochstrasser M
  Title
Molecular architecture and assembly of the eukaryotic proteasome.
  Journal
Annu Rev Biochem 82:415-45 (2013)
DOI:10.1146/annurev-biochem-060410-150257
Reference
PMID:28583440
  Authors
Budenholzer L, Cheng CL, Li Y, Hochstrasser M
  Title
Proteasome Structure and Assembly.
  Journal
J Mol Biol 429:3500-3524 (2017)
DOI:10.1016/j.jmb.2017.05.027
Reference
PMID:29071527
  Authors
Cloos J, Roeten MS, Franke NE, van Meerloo J, Zweegman S, Kaspers GJ, Jansen G
  Title
(Immuno)proteasomes as therapeutic target in acute leukemia.
  Journal
Cancer Metastasis Rev 36:599-615 (2017)
DOI:10.1007/s10555-017-9699-4
Reference
PMID:22215586
  Authors
Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  Title
Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
  Journal
Proc Natl Acad Sci U S A 109:1479-84 (2012)
DOI:10.1073/pnas.1119394109
Related
pathway
nta04120  Ubiquitin mediated proteolysis
KO pathway
ko03050   
LinkDB

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