KEGG   PATHWAY: paec03070
Entry
paec03070                   Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa c7447m
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
paec03070  Bacterial secretion system
paec03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa c7447m [GN:paec]
Gene
M802_4274  outer membrane efflux family protein [KO:K12340]
M802_5144  type I secretion outer membrane, TolC family protein [KO:K12340]
M802_4741  outer membrane efflux family protein [KO:K12340]
M802_1763  eprI; type III secretion apparatus needle protein [KO:K03221]
M802_1740  type III secretion YscO family protein [KO:K04056]
M802_1739  type III secretion system needle length determinant [KO:K04057]
M802_1745  type III secretion protein, YscX family [KO:K04059]
M802_1760  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
M802_1742  type III secretion regulator YopN/LcrE/InvE/MxiC [KO:K04058]
M802_1767  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
M802_1737  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
M802_1736  type III secretion, HrpO family protein [KO:K03227]
M802_1735  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
M802_1734  yscU; yscU [KO:K03229]
M802_1747  type III secretion, HrcV family protein [KO:K03230]
M802_1741  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
M802_1738  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
M802_1769  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
M802_1420  bacterial type II and III secretion system family protein [KO:K02453]
M802_703  gspD; type II secretion system protein D [KO:K02453]
M802_1925  gspD; type II secretion system protein D [KO:K02453]
M802_3212  gspD; type II secretion system protein D [KO:K02453]
M802_696  type IV pilus biogenesis family protein [KO:K02452]
M802_1924  type IV pilus biogenesis family protein [KO:K02452]
M802_3211  xcpP; general secretion pathway protein N [KO:K02452]
M802_705  gspF; type II secretion system protein F [KO:K02455]
M802_2754  type II secretion system (T2SS), F family protein [KO:K02455]
M802_3209  gspF; type II secretion system protein F [KO:K02455]
M802_698  gspG; type II secretion system protein G [KO:K02456]
M802_2752  hypothetical protein [KO:K02456]
M802_2753  gspG; type II secretion system protein G [KO:K02456]
M802_3208  gspG; type II secretion system protein G [KO:K02456]
M802_695  gspH; type II secretion system protein H [KO:K02457]
M802_3207  gspH; type II secretion system protein H [KO:K02457]
M802_697  gspI; type II secretion system protein I [KO:K02458]
M802_2751  hypothetical protein [KO:K02458]
M802_3206  gspI; type II secretion system protein I [KO:K02458]
M802_694  hypothetical protein [KO:K02459]
M802_2750  type II secretion system (T2SS), J family protein [KO:K02459]
M802_3205  gspJ; type II secretion system protein J [KO:K02459]
M802_699  type II secretion system (T2SS), K family protein [KO:K02460]
M802_3204  type II secretion system (T2SS), K family protein [KO:K02460]
M802_3203  gspL; type II secretion system protein L [KO:K02461]
M802_702  type II secretion system (T2SS), M family protein [KO:K02462]
M802_3202  type II secretion system (T2SS), M family protein [KO:K02462]
M802_704  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
M802_5386  hypothetical protein [KO:K02454] [EC:7.4.2.8]
M802_3210  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
M802_3944  secD; export membrane protein SecD [KO:K03072]
M802_3943  secF; export membrane protein SecF [KO:K03074]
M802_4373  secY; preprotein translocase, SecY subunit [KO:K03076]
M802_3945  yajC; preprotein translocase, YajC subunit [KO:K03210]
M802_5753  yidC; membrane protein insertase [KO:K03217]
M802_4546  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
M802_382  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
M802_5299  secB; protein-export chaperone SecB [KO:K03071]
M802_3867  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
M802_5239  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
M802_5240  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
M802_5241  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
M802_97  Rhs element Vgr family protein [KO:K11904]
M802_2764  Rhs element Vgr family protein [KO:K11904]
M802_267  Rhs element Vgr family protein [KO:K11904]
M802_5444  Rhs element Vgr family protein [KO:K11904]
M802_2443  Rhs element Vgr family protein [KO:K11904]
M802_3608  Rhs element Vgr family protein [KO:K11904]
M802_101  Rhs element Vgr family protein [KO:K11904]
M802_5261  Rhs element Vgr family protein [KO:K11904]
M802_3409  Rhs element Vgr family protein [KO:K11904]
M802_1551  hcpC; major exported protein [KO:K11903]
M802_91  hcp1; protein hcp1 [KO:K11903]
M802_268  hcpC; major exported protein [KO:K11903]
M802_2438  hypothetical protein [KO:K11903]
M802_5445  hcpC; major exported protein [KO:K11903]
M802_1709  type VI secretion lipofamily protein [KO:K11906]
M802_86  type VI secretion lipofamily protein [KO:K11906]
M802_1712  intracellular multiplication and macrophage-killing family protein [KO:K11891]
M802_83  intracellular multiplication and macrophage-killing family protein [KO:K11891]
M802_2432  hypothetical protein [KO:K11891]
M802_1711  type IV/VI secretion system, DotU family domain protein [KO:K11892]
M802_84  type VI secretion system OmpA/MotB family protein [KO:K11892]
M802_2433  type IV/VI secretion system, DotU family domain protein [KO:K11892]
M802_1705  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
M802_96  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
M802_2442  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
M802_80  phosphotransferase enzyme family protein [KO:K11912] [EC:2.7.11.1]
M802_87  FHA domain protein [KO:K11913]
M802_1713  stage II sporulation E family protein [KO:K11915] [EC:3.1.3.16]
M802_81  stage II sporulation E family protein [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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