KEGG   PATHWAY: paei02010
Entry
paei02010                   Pathway                                
Name
ABC transporters - Pseudomonas aeruginosa PAO1-VE2
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
paei02010  ABC transporters
paei02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Pseudomonas aeruginosa PAO1-VE2 [GN:paei]
Gene
N296_1535  sulfate ABC transporter, sulfate-binding family protein [KO:K02048]
N296_289  sulfate ABC transporter, sulfate-binding family protein [KO:K23163]
N296_288  cysT; sulfate ABC transporter, permease protein CysT [KO:K02046]
N296_287  cysW; sulfate ABC transporter, permease protein CysW [KO:K02047]
N296_286  cysA; sulfate ABC transporter, ATP-binding family protein [KO:K02045] [EC:7.3.2.3]
N296_4067  tauA; taurine ABC transporter, periplasmic binding protein [KO:K15551]
N296_4065  binding--dependent transport system inner membrane component family protein [KO:K15552]
N296_4066  ABC transporter family protein [KO:K10831] [EC:7.6.2.7]
N296_3568  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_3572  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_2673  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_2674  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_2675  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_191  NMT1-like family protein [KO:K15553]
N296_2678  ABC transporter, substrate-binding, aliphatic sulfonates family protein [KO:K15553]
N296_2382  NMT1-like family protein [KO:K15553]
N296_2369  NMT1-like family protein [KO:K15553]
N296_3566  binding--dependent transport system inner membrane component family protein [KO:K15554]
N296_3571  binding--dependent transport system inner membrane component family protein [KO:K15554]
N296_190  binding--dependent transport system inner membrane component family protein [KO:K15554]
N296_2380  binding--dependent transport system inner membrane component family protein [KO:K15554]
N296_2368  binding--dependent transport system inner membrane component family protein [KO:K15554]
N296_3565  ssuB; aliphatic sulfonates import ATP-binding protein SsuB [KO:K15555] [EC:7.6.2.14]
N296_3570  ssuB; aliphatic sulfonates import ATP-binding protein SsuB [KO:K15555] [EC:7.6.2.14]
N296_189  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
N296_2381  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
N296_2367  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
N296_1921  modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
N296_1920  modB; molybdate ABC transporter, permease protein [KO:K02018]
N296_1919  modC; molybdate ABC transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
N296_5395  bacterial extracellular solute-binding family protein [KO:K02012]
N296_4844  fbpA; iron-utilization periplasmic protein [KO:K02012]
N296_5394  binding--dependent transport system inner membrane component family protein [KO:K02011]
N296_4845  binding--dependent transport system inner membrane component family protein [KO:K02011]
N296_3661  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
N296_209  bacterial extracellular solute-binding family protein [KO:K11069]
N296_3734  bacterial extracellular solute-binding family protein [KO:K11069]
N296_331  bacterial extracellular solute-binding family protein [KO:K11069]
N296_210  binding--dependent transport system inner membrane component family protein [KO:K11070]
N296_3733  binding--dependent transport system inner membrane component family protein [KO:K11070]
N296_332  binding--dependent transport system inner membrane component family protein [KO:K11070]
N296_211  binding--dependent transport system inner membrane component family protein [KO:K11071]
N296_3732  binding--dependent transport system inner membrane component family protein [KO:K11071]
N296_333  binding--dependent transport system inner membrane component family protein [KO:K11071]
N296_212  polyamine ABC transporter, ATP-binding family protein [KO:K11072] [EC:7.6.2.11]
N296_3731  polyamine ABC transporter, ATP-binding family protein [KO:K11072] [EC:7.6.2.11]
N296_334  polyamine ABC transporter, ATP-binding family protein [KO:K11072] [EC:7.6.2.11]
N296_2793  bacterial extracellular solute-binding family protein [KO:K11073]
N296_2671  bacterial extracellular solute-binding family protein [KO:K11073]
N296_301  bacterial extracellular solute-binding family protein [KO:K11073]
N296_306  bacterial extracellular solute-binding family protein [KO:K11073]
N296_307  bacterial extracellular solute-binding family protein [KO:K11073]
N296_1451  potF; putrescine-binding periplasmic protein [KO:K11073]
N296_310  binding--dependent transport system inner membrane component family protein [KO:K11074]
N296_309  binding--dependent transport system inner membrane component family protein [KO:K11075]
N296_308  polyamine ABC transporter, ATP-binding family protein [KO:K11076] [EC:7.6.2.16]
N296_30  choX; choline ABC transporter, periplasmic binding family protein [KO:K02002]
N296_5269  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002]
N296_5276  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002]
N296_5573  choX; choline ABC transporter, periplasmic binding family protein [KO:K02002]
N296_5563  choX; choline ABC transporter, periplasmic binding family protein [KO:K02002]
N296_3348  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002]
N296_5268  binding--dependent transport system inner membrane component family protein [KO:K02001]
N296_5562  choW; choline ABC transporter, permease protein [KO:K02001]
N296_5267  proV; glycine betaine/L-proline transport ATP binding subunit [KO:K02000] [EC:7.6.2.9]
N296_5561  choV; choline ABC transporter, ATP-binding protein [KO:K02000] [EC:7.6.2.9]
N296_4017  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K05845]
N296_4016  binding--dependent transport system inner membrane component family protein [KO:K05846]
N296_4018  binding--dependent transport system inner membrane component family protein [KO:K05846]
N296_4019  proV; glycine betaine/L-proline transport ATP binding subunit [KO:K05847] [EC:7.6.2.9]
N296_2415  ABC transporter family protein [KO:K10111] [EC:7.5.2.-]
N296_3298  ABC transporter family protein [KO:K10112] [EC:7.5.2.-]
N296_2412  bacterial extracellular solute-binding family protein [KO:K10227]
N296_2413  binding--dependent transport system inner membrane component family protein [KO:K10228]
N296_2414  binding--dependent transport system inner membrane component family protein [KO:K10229]
N296_4598  toluene tolerance, Ttg2 family protein [KO:K07323]
N296_4599  mce related family protein [KO:K02067]
N296_3325  mce related family protein [KO:K02067]
N296_4600  hypothetical protein [KO:K02066]
N296_3323  hypothetical protein [KO:K02066]
N296_4597  STAS domain protein [KO:K07122]
N296_4601  ABC transporter family protein [KO:K02065]
N296_3324  ABC transporter family protein [KO:K02065]
N296_152  basic membrane family protein [KO:K07335]
N296_143  branched-chain amino acid transport system / permease component family protein [KO:K23535]
N296_144  branched-chain amino acid transport system / permease component family protein [KO:K23536]
N296_142  ABC transporter family protein [KO:K23537]
N296_3301  bacterial extracellular solute-binding family protein [KO:K17315]
N296_3300  binding--dependent transport system inner membrane component family protein [KO:K17316]
N296_3299  binding--dependent transport system inner membrane component family protein [KO:K17317]
N296_2008  periplasmic binding s and sugar binding domain of LacI family protein [KO:K10439]
N296_2010  branched-chain amino acid transport system / permease component family protein [KO:K10440]
N296_2009  ABC transporter family protein [KO:K10441] [EC:7.5.2.7]
N296_2620  PBP superfamily domain protein [KO:K02040]
N296_5549  pstS; alkaline phosphatase L [KO:K02040]
N296_5548  binding--dependent transport system inner membrane component family protein [KO:K02037]
N296_5547  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
N296_5546  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
N296_3432  phnD; ABC transporter [KO:K02044]
N296_3503  phnD; ABC transporter [KO:K02044]
N296_3434  binding--dependent transport system inner membrane component family protein [KO:K02042]
N296_3435  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
N296_3502  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
N296_3433  ABC transporter family protein [KO:K02041] [EC:7.3.2.2]
N296_3504  phnC; phosphonate ABC transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
N296_3028  hisM; histidine transport system permease protein hisM [KO:K10015]
N296_3027  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10016]
N296_3029  ABC transporter family protein [KO:K10017] [EC:7.4.2.1]
N296_3026  bacterial extracellular solute-binding s, 3 family protein [KO:K10014]
N296_1382  bacterial extracellular solute-binding s, 3 family protein [KO:K10001]
N296_1380  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10002]
N296_1381  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10003]
N296_1379  ABC transporter family protein [KO:K10004] [EC:7.4.2.1]
N296_3984  bacterial extracellular solute-binding s, 3 family protein [KO:K09969]
N296_322  bacterial extracellular solute-binding s, 3 family protein [KO:K02424]
N296_321  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10009]
N296_916  lysine-arginine-ornithine-binding periplasmic family protein [KO:K10022]
N296_3991  lysine-arginine-ornithine-binding periplasmic family protein [KO:K10022]
N296_918  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10023]
N296_917  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10024]
N296_920  ABC transporter family protein [KO:K10025] [EC:7.4.2.1]
N296_5329  bacterial extracellular solute-binding s, 3 family protein [KO:K23055]
N296_5330  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K23056]
N296_5331  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K23057]
N296_5328  ABC transporter family protein [KO:K23058] [EC:7.4.2.1]
N296_1299  bacterial extracellular solute-binding s, 3 family protein [KO:K23061]
N296_1297  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K23062]
N296_1296  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K23063]
N296_1295  ABC transporter family protein [KO:K23064] [EC:7.4.2.1]
N296_1111  braC; leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
N296_3483  amiC; aliphatic amidase expression-regulating protein [KO:K01999]
N296_5083  receptor ligand binding region family protein [KO:K01999]
N296_1110  branched-chain amino acid transport system / permease component family protein [KO:K01997]
N296_5082  branched-chain amino acid transport system / permease component family protein [KO:K01997]
N296_1109  branched-chain amino acid transport system / permease component family protein [KO:K01998]
N296_5081  branched-chain amino acid transport system / permease component family protein [KO:K01998]
N296_1108  ABC transporter family protein [KO:K01995]
N296_5080  ABC transporter family protein [KO:K01995]
N296_1107  ABC transporter family protein [KO:K01996]
N296_5079  ABC transporter family protein [KO:K01996]
N296_5692  lipo, YaeC family protein [KO:K02073]
N296_2423  NLPA lipofamily protein [KO:K02073]
N296_4060  ABC transporter, phosphonate, periplasmic substrate-binding family protein [KO:K02073]
N296_5691  binding--dependent transport system inner membrane component family protein [KO:K02072]
N296_2425  binding--dependent transport system inner membrane component family protein [KO:K02072]
N296_5690  ABC transporter family protein [KO:K02071]
N296_2424  ABC transporter family protein [KO:K02071]
N296_5028  periplasmic binding domain protein [KO:K11959]
N296_5029  urtB; urea ABC transporter, permease protein UrtB [KO:K11960]
N296_5030  urtC; urea ABC transporter, permease protein UrtC [KO:K11961]
N296_5031  urtD; urea ABC transporter, ATP-binding protein UrtD [KO:K11962]
N296_5032  urtE; urea ABC transporter, ATP-binding protein UrtE [KO:K11963]
N296_4642  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368]
N296_4643  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368]
N296_4646  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368]
N296_4648  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368]
N296_5497  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K12368]
N296_4649  binding--dependent transport system inner membrane component family protein [KO:K12369]
N296_4650  binding--dependent transport system inner membrane component family protein [KO:K12370]
N296_4651  hypothetical protein [KO:K12371]
N296_4652  hypothetical protein [KO:K12372]
N296_1865  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13893]
N296_1866  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13893]
N296_2122  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13893]
N296_1864  binding--dependent transport system inner membrane component family protein [KO:K13894]
N296_2123  binding--dependent transport system inner membrane component family protein [KO:K13894]
N296_1863  binding--dependent transport system inner membrane component family protein [KO:K13895]
N296_2124  binding--dependent transport system inner membrane component family protein [KO:K13895]
N296_1862  nikE; nickel import ATP-binding protein NikE [KO:K13896]
N296_2125  nikE; nickel import ATP-binding protein NikE [KO:K13896]
N296_4291  fepB; ferrienterobactin-binding periplasmic protein [KO:K23185]
N296_4292  fecCD transport family protein [KO:K23186]
N296_4293  fecCD transport family protein [KO:K23187]
N296_4290  ABC transporter family protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
N296_4174  periplasmic binding family protein [KO:K06858]
N296_5685  periplasmic solute binding family protein [KO:K09815]
N296_2479  periplasmic solute binding family protein [KO:K09815]
N296_5688  ABC 3 transport family protein [KO:K09816]
N296_2481  ABC 3 transport family protein [KO:K09816]
N296_5687  ABC transporter family protein [KO:K09817] [EC:7.2.2.20]
N296_2480  ABC transporter family protein [KO:K09817] [EC:7.2.2.20]
N296_5639  ABC-2 type transporter family protein [KO:K09690]
N296_2759  ABC-2 type transporter family protein [KO:K09690]
N296_5638  ABC transporter family protein [KO:K09691] [EC:7.5.2.14]
N296_1427  hypothetical protein [KO:K09691] [EC:7.5.2.14]
N296_3091  liporeleasing system, transmembrane, LolC/E family protein [KO:K09808]
N296_3093  liporeleasing system, transmembrane, LolC/E family protein [KO:K09808]
N296_3092  lolD; liporeleasing system, ATP-binding protein [KO:K09810] [EC:7.6.2.-]
N296_1519  ccmD; heme exporter protein CcmD [KO:K02196]
N296_1518  ccmC; heme exporter CcmC family protein [KO:K02195]
N296_1517  ccmB; heme exporter protein CcmB [KO:K02194]
N296_1516  ccmA; heme ABC exporter, ATP-binding protein CcmA [KO:K02193] [EC:7.6.2.5]
N296_3954  putative permease YjgP/YjgQ family protein [KO:K07091]
N296_3953  putative permease YjgP/YjgQ family protein [KO:K11720]
N296_4607  ABC transporter family protein [KO:K06861] [EC:7.5.2.5]
N296_3515  ABC-2 transporter family protein [KO:K19341]
N296_3514  ABC transporter family protein [KO:K19340]
N296_385  ftsX-like permease family protein [KO:K09811]
N296_384  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
N296_5170  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
N296_4275  ABC transporter family protein [KO:K13409]
N296_3340  ABC transporter family protein [KO:K18893]
N296_1935  type I secretion system ATPase family protein [KO:K12541]
N296_3527  type I secretion system ATPase family protein [KO:K12536]
N296_1285  type I secretion system ATPase family protein [KO:K12536]
N296_2463  ABC transporter family protein [KO:K05685] [EC:7.6.2.-]
N296_2470  cyclic peptide transporter family protein [KO:K06160]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
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Proc Natl Acad Sci U S A 96:13571-6 (1999)
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Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
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Genome Res 11:2034-40 (2001)
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ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
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Mol Microbiol 57:1582-92 (2005)
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Mol Microbiol 43:703-15 (2002)
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J Bacteriol 190:3489-93 (2008)
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The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
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J Bacteriol 187:5861-7 (2005)
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The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
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J Bacteriol 189:8361-5 (2007)
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Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
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