KEGG   PATHWAY: paem03070
Entry
paem03070                   Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa MTB-1
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
paem03070  Bacterial secretion system
paem03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa MTB-1 [GN:paem]
Gene
U769_04125  membrane protein [KO:K12340]
U769_27245  channel protein TolC [KO:K12340]
U769_25150  membrane protein [KO:K12340]
U769_17130  type III export protein pscF [KO:K03221]
U769_17245  translocation protein in type III secretion [KO:K04056]
U769_17250  translocation protein in type III secretion [KO:K04057]
U769_17220  preprotein translocase X [KO:K04059]
U769_17145  secretin [KO:K03219]
U769_17235  type III secretion protein [KO:K04058]
U769_17110  preproteins translocase J [KO:K03222]
U769_17260  ssaR; flagellar biosynthesis protein FliP [KO:K03226]
U769_17265  preprotein translocase S [KO:K03227]
U769_17270  preprotein translocase T [KO:K03228]
U769_17275  preprotein translocase U [KO:K03229]
U769_17210  Low calcium response locus protein D [KO:K03230]
U769_17240  fliI; ATP synthase [KO:K03224] [EC:7.4.2.8]
U769_17255  type III secretion system protein [KO:K03225]
U769_17100  type III secretion system protein [KO:K03223]
U769_09375  general secretion pathway protein D [KO:K02453]
U769_22965  general secretion pathway protein D [KO:K02453]
U769_16315  general secretion pathway protein D [KO:K02453]
U769_18850  secretin [KO:K02453]
U769_09380  general secretion pathway protein N [KO:K02452]
U769_22995  hypothetical protein [KO:K02452]
U769_16320  pilus assembly protein PilZ [KO:K02452]
U769_11785  type II secretion system protein [KO:K02455]
U769_09390  general secretion pathway protein F [KO:K02455]
U769_22955  general secretion pathway protein F [KO:K02455]
U769_11790  type II secretion system protein G [KO:K02456]
U769_11795  type II secretion system protein [KO:K02456]
U769_09395  secretion system protein G [KO:K02456]
U769_22985  general secretion pathway protein G [KO:K02456]
U769_09400  general secretion pathway protein H [KO:K02457]
U769_23000  HxcU pseudopilin [KO:K02457]
U769_11800  type II secretion system protein [KO:K02458]
U769_09405  general secretion pathway protein I [KO:K02458]
U769_22990  general secretion pathway protein I [KO:K02458]
U769_11805  type II secretion system protein [KO:K02459]
U769_09410  general secretion pathway protein J [KO:K02459]
U769_23005  HxcW pseudopilin [KO:K02459]
U769_09415  general secretion pathway protein K [KO:K02460]
U769_22980  HxcX atypical pseudopilin [KO:K02460]
U769_09420  general secretion pathway protein L [KO:K02461]
U769_22975  type II secretion system protein [KO:K02461]
U769_09425  general secretion pathway protein M [KO:K02462]
U769_22970  type II secretion system protein [KO:K02462]
U769_09385  general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
U769_28695  type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
U769_22960  general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
U769_24590  type IV B pilus protein [KO:K02454] [EC:7.4.2.8]
U769_05765  secD; preprotein translocase subunit SecD [KO:K03072]
U769_05770  secF; preprotein translocase subunit SecF [KO:K03074]
U769_03470  preprotein translocase subunit SecE [KO:K03073]
U769_26075  preprotein translocase subunit SecG [KO:K03075]
U769_03635  secY; preprotein translocase subunit SecY [KO:K03076]
U769_05760  preprotein translocase subunit YajC [KO:K03210]
U769_30535  insertase [KO:K03217]
U769_23700  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
U769_01925  cell division protein FtsY [KO:K03110]
U769_28000  preprotein translocase subunit SecB [KO:K03071]
U769_06145  signal recognition particle protein Srp54 [KO:K03106] [EC:3.6.5.4]
U769_27715  tatA; preprotein translocase subunit TatA [KO:K03116]
U769_27720  tatB; preprotein translocase subunit TatB [KO:K03117]
U769_27725  twin-arginine protein translocation system subunit TatC [KO:K03118]
U769_27810  type IV secretion protein Rhs [KO:K11904]
U769_18205  VgrG protein [KO:K11904]
U769_28985  type IV secretion protein Rhs [KO:K11904]
U769_00505  type VI secretion protein ImpA [KO:K11904]
U769_00480  type VI secretion protein ImpA [KO:K11904]
U769_11725  type VI secretion protein ImpA [KO:K11904]
U769_22745  type IV secretion protein Rhs [KO:K11904]
U769_13370  type IV secretion protein Rhs [KO:K11904]
U769_08390  type IV secretion protein Rhs [KO:K11904]
U769_00450  hypothetical protein [KO:K11903]
U769_28990  hypothetical protein [KO:K11903]
U769_22740  hypothetical protein [KO:K11903]
U769_13400  hypothetical protein [KO:K11903]
U769_18200  hypothetical protein [KO:K11903]
U769_00425  type VI secretion protein [KO:K11906]
U769_22715  hypothetical protein [KO:K11906]
U769_17400  type VI secretion protein [KO:K11906]
U769_00410  type VI secretion protein IcmF [KO:K11891]
U769_22660  type VI secretion protein VasK [KO:K11891]
U769_13430  type VI secretion system protein ImpL [KO:K11891]
U769_17385  type VI secretion protein VasK [KO:K11891]
U769_00415  type VI secretion protein [KO:K11892]
U769_22725  hypothetical protein [KO:K11892]
U769_13425  type VI secretion system protein ImpK [KO:K11892]
U769_17390  OmpA family protein [KO:K11892]
U769_00475  ATPase AAA [KO:K11907]
U769_22680  ATPase AAA [KO:K11907]
U769_13380  ATPase [KO:K11907]
U769_17425  ATPase AAA [KO:K11907]
U769_00395  serine/threonine protein kinase [KO:K11912] [EC:2.7.11.1]
U769_00430  signal peptide protein [KO:K11913]
U769_00400  PppA [KO:K11915] [EC:3.1.3.16]
U769_17380  protein phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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