KEGG   PATHWAY: pag03070
Entry
pag03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa LESB58
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
pag03070  Bacterial secretion system
pag03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa LESB58 [GN:pag]
Gene
PLES_53621  probable outer membrane protein precursor [KO:K12340]
PLES_07831  probable outer membrane protein precursor [KO:K12340]
PLES_49761  probable outer membrane protein precursor [KO:K12340]
PLES_36101  pscF; type III export protein PscF [KO:K03221]
PLES_36311  pscO; translocation protein in type III secretion [KO:K04056]
PLES_36261  conserved hypothetical protein in type III secretion [KO:K04059]
PLES_36131  pscC; Type III secretion outer membrane protein PscC precursor [KO:K03219]
PLES_36291  popN; Type III secretion outer membrane protein PopN precursor [KO:K04058]
PLES_36061  pscJ; type III export protein PscJ [KO:K03222]
PLES_36331  pscR; translocation protein in type III secretion [KO:K03226]
PLES_36341  probable translocation protein in type III secretion [KO:K03227]
PLES_36351  pscT; translocation protein in type III secretion [KO:K03228]
PLES_36361  pscU; translocation protein in type III secretion [KO:K03229]
PLES_36241  pcrD; type III secretory apparatus protein PcrD [KO:K03230]
PLES_36301  ATP synthase in type III secretion system [KO:K03224] [EC:7.4.2.8]
PLES_36321  pscQ; translocation protein in type III secretion [KO:K03225]
PLES_36041  pscL; type III export protein PscL [KO:K03223]
PLES_46451  probable type II secretion system protein [KO:K02453]
PLES_19551  xcpQ; general secretion pathway protein D [KO:K02453]
PLES_34551  xqhA; secretion protein XqhA [KO:K02453]
PLES_46501  hypothetical protein [KO:K02452]
PLES_19561  xcpP; secretion protein XcpP [KO:K02452]
PLES_34561  xphA; XphA [KO:K02452]
PLES_19581  xcpS; general secretion pathway protein F [KO:K02455]
PLES_24281  probable type II secretion system protein [KO:K02455]
PLES_46431  probable type II secretion system protein [KO:K02455]
PLES_24291  probable type II secretion system protein [KO:K02456]
PLES_24301  probable type II secretion system protein [KO:K02456]
PLES_46481  HxcT pseudopilin [KO:K02456]
PLES_19591  xcpT; general secretion pathway protein G [KO:K02456]
PLES_46511  HxcU putative pseudopilin [KO:K02457]
PLES_19601  xcpU; General secretion pathway outer membrane protein H precursor [KO:K02457]
PLES_24311  probable type II secretion system protein [KO:K02458]
PLES_19611  xcpV; general secretion pathway protein I [KO:K02458]
PLES_46491  HxcV putative pseudopilin [KO:K02458]
PLES_24321  probable type II secretion system protein [KO:K02459]
PLES_46521  HxcW putative pseudopilin [KO:K02459]
PLES_19621  xcpW; general secretion pathway protein J [KO:K02459]
PLES_46471  HxcX atypical pseudopilin [KO:K02460]
PLES_19631  xcpX; general secretion pathway protein K [KO:K02460]
PLES_19641  xcpY; general secretion pathway protein L [KO:K02461]
PLES_19651  xcpZ; general secretion pathway protein M [KO:K02462]
PLES_46461  probable type II secretion system protein [KO:K02462]
PLES_56041  probable secretion pathway ATPase [KO:K02454] [EC:7.4.2.8]
PLES_19571  xcpR; general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
PLES_46441  probable type II secretion system protein [KO:K02454] [EC:7.4.2.8]
PLES_11531  secD; secretion protein SecD [KO:K03072]
PLES_11541  secF; secretion protein SecF [KO:K03074]
PLES_06521  secE; secretion protein SecE [KO:K03073]
PLES_51321  secG; secretion protein SecG [KO:K03075]
PLES_06851  secY; secretion protein SecY [KO:K03076]
PLES_11521  putative preprotein translocase [KO:K03210]
PLES_59641  putative inner membrane protein, 60 kDa [KO:K03217]
PLES_47821  secA; secretion protein SecA [KO:K03070] [EC:7.4.2.8]
PLES_03701  ftsY; signal recognition particle receptor FtsY [KO:K03110]
PLES_55181  secB; secretion protein SecB [KO:K03071]
PLES_12341  ffh; signal recognition particle protein Ffh [KO:K03106] [EC:3.6.5.4]
PLES_54581  tatA; translocation protein TatA [KO:K03116]
PLES_54591  tatB; translocation protein TatB [KO:K03117]
PLES_54601  tatC; transport protein TatC [KO:K03118]
PLES_02581  conserved hypothetical protein [KO:K11904]
PLES_17721  hypothetical protein [KO:K11904]
PLES_38991  conserved hypothetical protein [KO:K11904]
PLES_56601  conserved hypothetical protein [KO:K11904]
PLES_00921  conserved hypothetical protein [KO:K11904]
PLES_00961  conserved hypothetical protein [KO:K11904]
PLES_24191  conserved hypothetical protein [KO:K11904]
PLES_29291  conserved hypothetical protein [KO:K11904]
PLES_54801  conserved hypothetical protein [KO:K11904]
PLES_29361  hypothetical protein [KO:K11903]
PLES_02591  hcpC; secreted protein Hcp [KO:K11903]
PLES_38981  hcpA; secreted protein Hcp [KO:K11903]
PLES_56611  hcpB; secreted protein Hcp [KO:K11903]
PLES_00861  conserved hypothetical protein [KO:K11903]
PLES_00811  putative lipoprotein [KO:K11906]
PLES_36611  putative lipoprotein [KO:K11906]
PLES_36581  hypothetical protein [KO:K11891]
PLES_29421  hypothetical protein [KO:K11891]
PLES_00781  hypothetical protein [KO:K11891]
PLES_36591  putative outer membrane protein [KO:K11892]
PLES_29411  hypothetical protein [KO:K11892]
PLES_00791  hypothetical protein [KO:K11892]
PLES_36651  probable ClpA/B-type protease [KO:K11907]
PLES_00911  probable ClpA/B-type chaperone [KO:K11907]
PLES_29321  probable ClpA/B-type protease [KO:K11907]
PLES_00751  ppkA; serine/threonine protein kinase PpkA [KO:K11912] [EC:2.7.11.1]
PLES_00821  hypothetical protein [KO:K11913]
PLES_36571  stp1; serine/threonine phosphoprotein phosphatase Stp1 [KO:K11915] [EC:3.1.3.16]
PLES_00761  probable phosphoprotein phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
LinkDB

DBGET integrated database retrieval system