Entry
Name
ABC transporters - Pseudomonas aeruginosa UCBPP-PA14
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Pseudomonas aeruginosa UCBPP-PA14 [GN:
pau ]
Gene
PA14_12920 probable ABC-type taurine transporter, periplasmic component [KO:K15551 ]
PA14_30550 ssuA; putative periplasmic aliphatic sulfonate-binding protein [KO:K15553 ]
PA14_19540 ssuA; putative ABC-type transporter periplasmic sulfonate-binding protein [KO:K15553 ]
PA14_02360 atsR; putative binding protein component of ABC transporter [KO:K15553 ]
PA14_19570 ssuC; putative aliphatic sulfonates transport permease protein [KO:K15554 ]
PA14_40390 modA; molybdate-binding periplasmic protein precursor modA [KO:K02020 ]
PA14_68900 fbpA; putative iron ABC transporter, periplasmic iron-binding protein [KO:K02012 ]
PA14_46220 potF; putative periplasmic putrescine-binding permease protein [KO:K11073 ]
PA14_30570 potF; putative periplasmic spermidine/putrescine-binding protein [KO:K11073 ]
PA14_29090 potF4; putative periplasmic spermidine/putrescine-binding protein [KO:K11073 ]
PA14_67300 proX; putative binding protein component of ABC transporter [KO:K02002 ]
PA14_67400 putative ABC transporter, periplasmic substrate-binding protein [KO:K02002 ]
PA14_71030 putative glycine betaine/L-proline ABC transporter, periplasmic component [KO:K02002 ]
PA14_71160 putative glycine betaine/L-proline ABC transporter, periplasmic substrate-binding protein [KO:K02002 ]
PA14_00360 putative glycine betaine/L-proline ABC transporter, periplasmic substrate-binding protein [KO:K02002 ]
PA14_71020 putative BC-type proline/glycine betaine transport system, permease component [KO:K02001 ]
PA14_34370 mtlk; putative ATP-binding component of ABC maltose/mannitol transporter [KO:K10111 ] [EC:7.5.2.-]
PA14_23010 gltK; putative ATP-binding component of ABC transporter [KO:K10112 ] [EC:7.5.2.-]
PA14_34420 mtlE; putative binding protein component of ABC maltose/mannitol transporter [KO:K10227 ]
PA14_34410 mtlF; putative binding-protein-dependent maltose/mannitol transport protein [KO:K10228 ]
PA14_34390 mtlG; putative binding-protein-dependent maltose/mannitol transport protein [KO:K10229 ]
PA14_22980 gltB; putative binding protein component of ABC sugar transporter [KO:K17315 ]
PA14_39350 rbsB; binding protein component precursor of ABC ribose transporter [KO:K10439 ]
PA14_70860 putative phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040 ]
PA14_20320 phnD; binding protein component of ABC phosphonate transporter [KO:K02044 ]
PA14_21175 putative ABC-type phosphate/phosphonate transport system, periplasmic component [KO:K02044 ]
PA14_46910 ybeJ; putative binding protein component of ABC transporter [KO:K10001 ]
PA14_04090 fliY; putative binding protein component of ABC transporter [KO:K02424 ]
PA14_68070 putative ABC transporter, periplasmic amino acid-binding protein [KO:K23055 ]
PA14_64890 braD; putative permease of ABC branched chain amino acid transporter [KO:K01997 ]
PA14_64880 braE; putative permease of ABC branched-chain amino acid transporter [KO:K01998 ]
PA14_64870 braF; putative branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995 ]
PA14_64860 livF; putative ranched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996 ]
PA14_34280 metQ-l; putative ABC transporter, periplasmic binding protein [KO:K02073 ]
PA14_34270 metN-1; putative ATP-binding component of ABC transporter [KO:K02071 ]
PA14_64270 putative branched-chain amino acid ABC transporter, periplasmic component [KO:K11959 ]
PA14_64280 putative branched-chain amino acid ABC transporter, permease protein [KO:K11960 ]
PA14_70200 putative binding protein component of ABC dipeptide transporter [KO:K12368 ]
PA14_10170 fepB; ferrienterobactin-binding periplasmic protein precursor FepB [KO:K23185 ]
PA14_72550 znuA; putative zinc ABC transporter, periplasmic zinc-binding protein [KO:K09815 ]
PA14_25450 lolE; putative lipoprotein releasing system, permease protein [KO:K09808 ]
PA14_25430 lolC; putative lipoprotein releasing system, permease protein [KO:K09808 ]
PA14_25440 lolD; putative lipoprotein releasing system, ATP-binding protein [KO:K09810 ] [EC:7.6.2.-]
PA14_04920 ftsX; cell division ABC transporter, permease protein FtsX [KO:K09811 ]
PA14_22440 bapA; putative ATP-binding/permease fusion ABC transporter [KO:K18893 ]
PA14_33760 putative ATP-binding/permease fusion ABC transporter [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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