KEGG   PATHWAY: ppsd03060
Entry
ppsd03060                   Pathway                                
Name
Protein export - Podospora pseudocomata
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ppsd03060  Protein export
ppsd03060

Other DBs
GO: 0043952 0043953
Organism
Podospora pseudocomata [GN:ppsd]
Gene
QC762_207800  uncharacterized protein [KO:K03217]
QC762_000830  SRP54; Signal recognition particle [KO:K03106] [EC:3.6.5.4]
QC762_206490  SEC61; translocon subunit [KO:K10956]
QC762_103880  SBH1; Arf guanine nucleotide exchange factor sbh1 [KO:K09481]
QC762_210810  uncharacterized protein [KO:K07342]
QC762_122710  SEC62; Translocation protein S62 [KO:K12275]
QC762_710810  SEC63; secretory subunit [KO:K09540]
QC762_104560  KAR2_1; ATPase with role in protein import into the ER [KO:K09490] [EC:3.6.4.10]
QC762_406420  KAR2_2; ATPase with role in protein import into the ER [KO:K09490] [EC:3.6.4.10]
QC762_505790  hypothetical protein [KO:K03104]
QC762_205360  srp72; Signal recognition particle subunit SRP72 [KO:K03108]
QC762_602540  SRP68; signal recognition particle subunit srp68 [KO:K03107]
QC762_603860  SEC65; signal recognition particle subunit [KO:K03105]
QC762_114860  uncharacterized protein [KO:K13431]
QC762_703270  hypothetical protein [KO:K12272]
QC762_210780  GET3; Golgi to ER traffic-related protein [KO:K01551] [EC:7.3.2.7 7.3.-.-]
QC762_210470  uncharacterized protein [KO:K23387]
QC762_605730  hypothetical protein [KO:K23388]
QC762_303140  sgt2; Small glutamine-rich tetratricopeptide repeat-containing protein 2 [KO:K16365]
QC762_307110  GET1; GET complex subunit get1 [KO:K22384]
QC762_308345  hypothetical protein [KO:K22386]
QC762_702570  hypothetical protein [KO:K27164]
QC762_611790  PHO88; phosphate transporter (Pho88) [KO:K27165]
QC762_708740  hypothetical protein [KO:K12946] [EC:3.4.-.-]
QC762_607190  SEC11; Signal peptidase complex catalytic subunit [KO:K13280] [EC:3.4.21.89]
QC762_703420  SEC11C; Signal peptidase complex catalytic subunit S11C [KO:K13280] [EC:3.4.21.89]
QC762_205125  uncharacterized protein [KO:K09647] [EC:3.4.21.-]
QC762_605970  hypothetical protein [KO:K09648] [EC:3.4.21.-]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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