KEGG   PATHWAY: pss04136
Entry
pss04136                    Pathway                                
Name
Autophagy - other - Pelodiscus sinensis (Chinese soft-shelled turtle)
Description
Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pss04136  Autophagy - other
pss04136

Other DBs
GO: 0006914
Organism
Pelodiscus sinensis (Chinese soft-shelled turtle) [GN:pss]
Gene
102450550  RPTOR; regulatory-associated protein of mTOR isoform X3 [KO:K07204]
102451030  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
102451779  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102444812  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
102447911  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
102454741  ATG101; autophagy-related protein 101 [KO:K19730]
102451707  IGBP1; immunoglobulin-binding protein 1 [KO:K17606]
102446185  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102457538  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102450218  autophagy-related protein 9A-like [KO:K17907]
102461517  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
102460860  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
102449560  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
102458634  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
102460442  BECN1; beclin-1 [KO:K08334]
102445385  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102454205  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102447537  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
102456776  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
102462041  ATG16L1; autophagy-related protein 16-1 isoform X2 [KO:K17890]
102462167  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
102459714  ATG10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
102458795  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
102460066  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
102444496  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
102449838  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X3 [KO:K08341]
102445170  ATG4C; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
102443632  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
102445356  ATG4B; cysteine protease ATG4B isoform X2 [KO:K08342] [EC:3.4.22.-]
102457935  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  Title
Autophagy in protists.
  Journal
Autophagy 7:127-58 (2011)
DOI:10.4161/auto.7.2.13310
Reference
  Authors
Avin-Wittenberg T, Honig A, Galili G
  Title
Variations on a theme: plant autophagy in comparison to yeast and mammals.
  Journal
Protoplasma 249:285-99 (2012)
DOI:10.1007/s00709-011-0296-z
Reference
  Authors
Liu Y, Bassham DC
  Title
Autophagy: pathways for self-eating in plant cells.
  Journal
Annu Rev Plant Biol 63:215-37 (2012)
DOI:10.1146/annurev-arplant-042811-105441
Reference
  Authors
Yoshimoto K
  Title
Beginning to understand autophagy, an intracellular self-degradation system in plants.
  Journal
Plant Cell Physiol 53:1355-65 (2012)
DOI:10.1093/pcp/pcs099
Reference
  Authors
Li F, Chung T, Vierstra RD
  Title
AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  Journal
Plant Cell 26:788-807 (2014)
DOI:10.1105/tpc.113.120014
Reference
  Authors
Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  Title
Autophagy in Plants--What's New on the Menu?
  Journal
Trends Plant Sci 21:134-44 (2016)
DOI:10.1016/j.tplants.2015.10.008
Reference
  Authors
Yang X, Bassham DC
  Title
New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  Journal
Int Rev Cell Mol Biol 320:1-40 (2015)
DOI:10.1016/bs.ircmb.2015.07.005
KO pathway
ko04136   
LinkDB

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