KEGG PATHWAY: ptt03070

KEGG

PATHWAY: ptt03070

Entry

ptt03070                    Pathway

Name

Bacterial secretion system - Photorhabdus thracensis

Description

Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.

Class

Environmental Information Processing; Membrane transport

Pathway map

Bacterial secretion system

Other DBs

GO:	0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953

Organism

Photorhabdus thracensis [GN:ptt]

Gene

membrane protein [KO:K12340]

membrane protein [KO:K12340]

type III export protein pscF [KO:K03221]

type III secretion protein [KO:K04056]

hypothetical protein [KO:K04057]

type III secretion protein [KO:K04059]

secretin [KO:K03219]

type III secretion protein [KO:K04058]

preproteins translocase J [KO:K03222]

ssaR; type III secretion system protein SsaR [KO:K03226]

preprotein translocase S [KO:K03227]

preprotein translocase T [KO:K03228]

preprotein translocase U [KO:K03229]

Low calcium response locus protein D [KO:K03230]

fliI; ATP synthase [KO:K03224] [EC:7.4.2.8]

type III secretion protein [KO:K03225]

type III secretion system protein [KO:K03223]

pilus assembly protein [KO:K02464] [EC:3.4.23.43 2.1.1.-]

prepilin [KO:K02464] [EC:3.4.23.43 2.1.1.-]

secD; preprotein translocase subunit SecD [KO:K03072]

preprotein translocase subunit SecF [KO:K03074]

secE; preprotein translocase subunit SecE [KO:K03073]

preprotein translocase subunit SecG [KO:K03075]

secY; preprotein translocase subunit SecY [KO:K03076]

yajC; preprotein translocase subunit YajC [KO:K03210]

membrane protein insertase [KO:K03217]

secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]

secretion protein [KO:K13301]

cell division protein FtsY [KO:K03110]

preprotein translocase subunit SecB [KO:K03071]

signal recognition particle [KO:K03106] [EC:3.6.5.4]

preprotein translocase subunit TatA [KO:K03116]

preprotein translocase subunit TatB [KO:K03117]

twin-arginine protein translocation system subunit TatC [KO:K03118]

hemolysin activation protein [KO:K11017]

hemolysin activation protein [KO:K11016]

type IV secretion protein Rhs [KO:K11904]

type VI secretion protein [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

Vrg family protein [KO:K11904]

type IV secretion protein Rhs [KO:K11904]

hypothetical protein [KO:K11904]

Vrg family protein [KO:K11904]

hypothetical protein [KO:K11904]

hypothetical protein [KO:K11904]

hypothetical protein [KO:K11904]

hypothetical protein [KO:K11903]

Hcp family T6SS protein CtsH1 [KO:K11903]

Hcp family T6SS protein CtsH1 [KO:K11903]

major exported protein [KO:K11903]

hypothetical protein [KO:K11903]

Hcp family T6SS protein CtsH1 [KO:K11903]

hypothetical protein [KO:K11906]

type VI secretion protein [KO:K11906]

type VI secretion protein [KO:K11906]

type VI secretion protein [KO:K11906]

type VI secretion protein [KO:K11906]

type VI secretion protein IcmF [KO:K11891]

type VI secretion protein IcmF [KO:K11891]

hypothetical protein [KO:K11891]

hypothetical protein [KO:K11891]

type VI secretion protein VasK [KO:K11891]

type VI secretion protein VasK [KO:K11891]

type VI secretion protein VasK [KO:K11891]

type VI secretion protein VasK [KO:K11891]

membrane protein [KO:K11892]

hypothetical protein [KO:K11892]

hypothetical protein [KO:K11892]

type VI secretion protein ImpK [KO:K11892]

type VI secretion protein ImpK [KO:K11892]

membrane protein [KO:K11892]

type VI secretion protein ImpK [KO:K11892]

molecular chaperone [KO:K11907]

ATPase [KO:K11907]

ATPase [KO:K11907]

ATPase [KO:K11907]

Clp protease ClpV [KO:K11907]

ATPase [KO:K11907]

Compound

ATP

Reference

Authors

Kim JF.

Title

Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.

Journal

Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2

Reference

Authors

Plano GV, Day JB, Ferracci F.

Title

Type III export: new uses for an old pathway.

Journal

Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x

Reference

Authors

Gauthier A, Finlay BB.

Title

Bacterial pathogenesis: the answer to virulence is in the pore.

Journal

Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8

Reference

Authors

Burns DL.

Title

Biochemistry of type IV secretion.

Journal

Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6

Reference

Authors

Christie PJ, Vogel JP.

Title

Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Journal

Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3

Reference

Authors

Christie PJ.

Title

Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Journal

Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x

Reference

Authors

Nunn D.

Title

Bacterial type II protein export and pilus biogenesis: more than just homologies?

Journal

Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7

Reference

Authors

Sandkvist M.

Title

Biology of type II secretion.

Journal

Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x

Reference

Authors

Sandkvist M.

Title

Type II secretion and pathogenesis.

Journal

Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001

Reference

Authors

Delepelaire P

Title

Type I secretion in gram-negative bacteria.

Journal

Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001

Reference

Authors

Hazes B, Frost L

Title

Towards a systems biology approach to study type II/IV secretion systems.

Journal

Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011

Reference

Authors

Johnson TL, Abendroth J, Hol WG, Sandkvist M

Title

Type II secretion: from structure to function.

Journal

FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x

Reference

Authors

Filloux A

Title

The underlying mechanisms of type II protein secretion.

Journal

Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003

Reference

Authors

Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Title

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Journal

Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603

Reference

Authors

Ghosh P

Title

Process of protein transport by the type III secretion system.

Journal

Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004

Reference

Authors

Cornelis GR

Title

The Yersinia Ysc-Yop 'type III' weaponry.

Journal

Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932

Reference

Authors

Baron C

Title

VirB8: a conserved type IV secretion system assembly factor and drug target.

Journal

Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148

Reference

Authors

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S

Title

Helicobacter exploits integrin for type IV secretion and kinase activation.

Journal

Nature 449:862-6 (2007)
DOI:10.1038/nature06187

Reference

Authors

Christie PJ, Cascales E

Title

Structural and dynamic properties of bacterial type IV secretion systems (review).

Journal

Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316

Reference

Authors

Christie PJ

Title

Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.

Journal

Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013

Reference

Authors

Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D

Title

Type V protein secretion pathway: the autotransporter story.

Journal

Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004

Reference

Authors

Henderson IR, Navarro-Garcia F, Nataro JP

Title

The great escape: structure and function of the autotransporter proteins.

Journal

Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3

Reference

Authors

Filloux A, Hachani A, Bleves S

Title

The bacterial type VI secretion machine: yet another player for protein transport across membranes.

Journal

Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0

Reference

Authors

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ

Title

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Journal

Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106

Reference

Authors

Kulasekara HD, Miller SI

Title

Threonine phosphorylation times bacterial secretion.

Journal

Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734

Reference

Authors

Driessen AJ, Nouwen N

Title

Protein translocation across the bacterial cytoplasmic membrane.

Journal

Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747

Reference

Authors

Pool MR

Title

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

Journal

Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232

Reference

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004

Reference

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

KO pathway

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