KEGG   PATHWAY: pxn02010
Entry
pxn02010                    Pathway                                
Name
ABC transporters - Pseudomonas xantholysinigenes
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
pxn02010  ABC transporters
pxn02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Pseudomonas xantholysinigenes [GN:pxn]
Gene
HU772_016870  sulfate ABC transporter substrate-binding protein [KO:K02048]
HU772_023745  sulfate ABC transporter substrate-binding protein [KO:K23163]
HU772_023740  cysT; sulfate ABC transporter permease subunit CysT [KO:K02046]
HU772_023735  cysW; sulfate ABC transporter permease subunit CysW [KO:K02047]
HU772_023730  sulfate ABC transporter ATP-binding protein [KO:K02045] [EC:7.3.2.3]
HU772_023915  tauA; taurine ABC transporter substrate-binding protein [KO:K15551]
HU772_023925  tauC; taurine ABC transporter permease TauC [KO:K15552]
HU772_023920  tauB; taurine ABC transporter ATP-binding subunit [KO:K10831] [EC:7.6.2.7]
HU772_023895  sulfonate ABC transporter substrate-binding protein [KO:K15553]
HU772_000915  ABC transporter substrate-binding protein [KO:K15553]
HU772_023885  ssuC; aliphatic sulfonate ABC transporter permease SsuC [KO:K15554]
HU772_000910  ABC transporter permease subunit [KO:K15554]
HU772_023880  ssuB; aliphatic sulfonates ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
HU772_000905  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
HU772_009720  substrate-binding domain-containing protein [KO:K02020]
HU772_010500  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
HU772_010495  modB; molybdate ABC transporter permease subunit [KO:K02018]
HU772_010490  modC; molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
HU772_022265  extracellular solute-binding protein [KO:K02012]
HU772_023535  putative 2-aminoethylphosphonate ABC transporter substrate-binding protein [KO:K02012]
HU772_023870  extracellular solute-binding protein [KO:K02012]
HU772_022270  iron ABC transporter permease [KO:K02011]
HU772_023540  putative 2-aminoethylphosphonate ABC transporter permease subunit [KO:K02011]
HU772_023865  iron ABC transporter permease [KO:K02011]
HU772_023545  putative 2-aminoethylphosphonate ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
HU772_005640  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
HU772_015790  extracellular solute-binding protein [KO:K11073]
HU772_016130  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_020270  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_023790  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_023795  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_024615  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_004005  extracellular solute-binding protein [KO:K11073]
HU772_013325  polyamine ABC transporter substrate-binding protein [KO:K11073]
HU772_023775  ABC transporter permease subunit [KO:K11074]
HU772_023780  ABC transporter permease subunit [KO:K11075]
HU772_023785  potA; polyamine ABC transporter ATP-binding protein [KO:K11076] [EC:7.6.2.16]
HU772_006650  glycine betaine ABC transporter substrate-binding protein [KO:K02002]
HU772_011915  ABC transporter substrate-binding protein [KO:K02002]
HU772_000170  choX; choline ABC transporter substrate-binding protein [KO:K02002]
HU772_001600  choline ABC transporter substrate-binding protein [KO:K02002]
HU772_001640  choX; choline ABC transporter substrate-binding protein [KO:K02002]
HU772_011910  ABC transporter permease subunit [KO:K02001]
HU772_001595  choW; choline ABC transporter permease subunit [KO:K02001]
HU772_016955  hypothetical protein [KO:K02000] [EC:7.6.2.9]
HU772_001590  choV; choline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
HU772_020295  glycine betaine ABC transporter substrate-binding protein [KO:K05845]
HU772_020290  ABC transporter permease [KO:K05846]
HU772_020300  ABC transporter permease [KO:K05846]
HU772_020305  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
HU772_010790  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10111] [EC:7.5.2.-]
HU772_019760  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10112] [EC:7.5.2.-]
HU772_010805  sugar ABC transporter substrate-binding protein [KO:K10227]
HU772_010800  sugar ABC transporter permease [KO:K10228]
HU772_010795  carbohydrate ABC transporter permease [KO:K10229]
HU772_020000  ABC transporter substrate-binding protein [KO:K07323]
HU772_020005  mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
HU772_000520  MCE family protein [KO:K02067]
HU772_020010  mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066]
HU772_000530  ABC transporter permease [KO:K02066]
HU772_019995  STAS domain-containing protein [KO:K07122]
HU772_020015  ATP-binding cassette domain-containing protein [KO:K02065]
HU772_000525  ATP-binding cassette domain-containing protein [KO:K02065]
HU772_019775  ABC transporter substrate-binding protein [KO:K17315]
HU772_019770  sugar ABC transporter permease [KO:K17316]
HU772_019765  carbohydrate ABC transporter permease [KO:K17317]
HU772_010620  sugar ABC transporter substrate-binding protein [KO:K10439]
HU772_010630  ABC transporter permease [KO:K10440]
HU772_010625  sugar ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
HU772_010645  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
HU772_015255  phosphate ABC transporter substrate-binding/OmpA family protein [KO:K02040]
HU772_024555  phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
HU772_024550  ABC transporter permease subunit [KO:K02037]
HU772_024545  pstA; phosphate ABC transporter permease PstA [KO:K02038]
HU772_024540  pstB; phosphate ABC transporter ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
HU772_020520  putative selenate ABC transporter substrate-binding protein [KO:K02044]
HU772_020505  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
HU772_020510  ABC transporter permease subunit [KO:K02042]
HU772_020515  phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
HU772_008735  ABC transporter permease [KO:K10015]
HU772_008740  ABC transporter permease [KO:K10016]
HU772_008730  ATP-binding cassette domain-containing protein [KO:K10017] [EC:7.4.2.1]
HU772_008745  ABC transporter substrate-binding protein [KO:K10014]
HU772_005600  glutamate/aspartate ABC transporter substrate-binding protein [KO:K10001]
HU772_005590  ABC transporter permease subunit [KO:K10002]
HU772_005595  amino acid ABC transporter permease [KO:K10003]
HU772_005585  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
HU772_004465  amino acid ABC transporter substrate-binding protein [KO:K09969]
HU772_004470  amino acid ABC transporter permease [KO:K09970]
HU772_004475  amino acid ABC transporter permease [KO:K09971]
HU772_004480  amino acid ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
HU772_023645  transporter substrate-binding domain-containing protein [KO:K02424]
HU772_023945  tcyJ; cystine ABC transporter substrate-binding protein [KO:K02424]
HU772_023950  tcyL; cystine ABC transporter permease [KO:K10009]
HU772_023955  yecC; L-cystine ABC transporter ATP-binding protein YecC [KO:K10010] [EC:7.4.2.1]
HU772_017515  ABC transporter substrate-binding protein [KO:K10022]
HU772_017505  ABC transporter permease [KO:K10023]
HU772_017510  ABC transporter permease [KO:K10024]
HU772_017500  ATP-binding cassette domain-containing protein [KO:K10025] [EC:7.4.2.1]
HU772_001515  ABC transporter substrate-binding protein [KO:K23055]
HU772_001510  ABC transporter permease [KO:K23056]
HU772_001505  ABC transporter permease [KO:K23057]
HU772_001520  ABC transporter ATP-binding protein [KO:K23058] [EC:7.4.2.1]
HU772_005885  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
HU772_022190  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
HU772_005880  livH; high-affinity branched-chain amino acid ABC transporter permease LivH [KO:K01997]
HU772_022185  branched-chain amino acid ABC transporter permease LivH [KO:K01997]
HU772_005875  high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998]
HU772_022180  livM; high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998]
HU772_005870  livG; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG [KO:K01995]
HU772_022175  ATP-binding cassette domain-containing protein [KO:K01995]
HU772_005865  ATP-binding cassette domain-containing protein [KO:K01996]
HU772_022170  ABC transporter ATP-binding protein [KO:K01996]
HU772_023700  MetQ/NlpA family ABC transporter substrate-binding protein [KO:K02073]
HU772_000375  MetQ/NlpA family ABC transporter substrate-binding protein [KO:K02073]
HU772_000990  MetQ/NlpA family ABC transporter substrate-binding protein [KO:K02073]
HU772_000380  ABC transporter permease [KO:K02072]
HU772_000980  ABC transporter permease [KO:K02072]
HU772_000385  methionine ABC transporter ATP-binding protein [KO:K02071]
HU772_000985  methionine ABC transporter ATP-binding protein [KO:K02071]
HU772_022060  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
HU772_022065  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
HU772_022070  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
HU772_022075  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
HU772_022080  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
HU772_020215  ABC transporter substrate-binding protein [KO:K12368]
HU772_020220  ABC transporter substrate-binding protein [KO:K12368]
HU772_020230  ABC transporter substrate-binding protein [KO:K12368]
HU772_024320  ABC transporter substrate-binding protein [KO:K12368]
HU772_020235  ABC transporter permease subunit [KO:K12369]
HU772_020240  ABC transporter permease subunit [KO:K12370]
HU772_020245  ABC transporter ATP-binding protein [KO:K12371]
HU772_020250  ABC transporter ATP-binding protein [KO:K12372]
HU772_011715  extracellular solute-binding protein [KO:K13893]
HU772_016060  extracellular solute-binding protein [KO:K13893]
HU772_016065  extracellular solute-binding protein [KO:K13893]
HU772_011710  microcin C ABC transporter permease YejB [KO:K13894]
HU772_016070  microcin C ABC transporter permease YejB [KO:K13894]
HU772_011705  ABC transporter permease [KO:K13895]
HU772_016075  ABC transporter permease [KO:K13895]
HU772_016080  ABC transporter ATP-binding protein [KO:K13896]
HU772_002810  cobalamin-binding protein [KO:K06858]
HU772_010880  metal ABC transporter substrate-binding protein [KO:K09815]
HU772_000415  zinc ABC transporter substrate-binding protein [KO:K09815]
HU772_010870  metal ABC transporter permease [KO:K09816]
HU772_000400  znuB; zinc ABC transporter permease subunit ZnuB [KO:K09816]
HU772_010875  metal ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
HU772_000405  znuC; zinc ABC transporter ATP-binding protein ZnuC [KO:K09817] [EC:7.2.2.20]
HU772_006925  ABC transporter permease [KO:K09690]
HU772_006930  ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
HU772_008360  lipoprotein-releasing ABC transporter permease subunit [KO:K09808]
HU772_008370  lipoprotein-releasing ABC transporter permease subunit [KO:K09808]
HU772_008365  lolD; lipoprotein-releasing ABC transporter ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
HU772_017025  ccmD; heme exporter protein CcmD [KO:K02196]
HU772_017030  heme ABC transporter permease [KO:K02195]
HU772_017035  ccmB; heme exporter protein CcmB [KO:K02194]
HU772_017040  ccmA; cytochrome c biogenesis heme-transporting ATPase CcmA [KO:K02193] [EC:7.6.2.5]
HU772_019910  lptF; LPS export ABC transporter permease LptF [KO:K07091]
HU772_019905  lptG; LPS export ABC transporter permease LptG [KO:K11720]
HU772_020040  lptB; LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
HU772_023390  ftsX; permease-like cell division protein FtsX [KO:K09811]
HU772_023395  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
HU772_022505  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
HU772_000300  type I secretion system permease/ATPase [KO:K11004]
HU772_015550  ABC transporter ATP-binding protein/permease [KO:K18893]
HU772_017825  ABC transporter ATP-binding protein/permease [KO:K18893]
HU772_017705  type I secretion system permease/ATPase [KO:K12541]
HU772_024095  type I secretion system permease/ATPase [KO:K12541]
HU772_007200  type I secretion system permease/ATPase [KO:K12536]
HU772_021365  type I secretion system permease/ATPase [KO:K12536]
HU772_012735  MacB family efflux pump subunit [KO:K05685] [EC:7.6.2.-]
HU772_016485  MacB family efflux pump subunit [KO:K05685] [EC:7.6.2.-]
HU772_010930  cyclic peptide export ABC transporter [KO:K06160]
HU772_008545  ABC transporter ATP-binding protein/permease [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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