KEGG   PATHWAY: rey02010
Entry
rey02010                    Pathway                                
Name
ABC transporters - Rhodococcus erythropolis CCM2595
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
rey02010  ABC transporters
rey02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Rhodococcus erythropolis CCM2595 [GN:rey]
Gene
O5Y_17325  sulfate ABC transporter sulfate-binding protein [KO:K23163]
O5Y_17320  sulfate ABC transporter permease [KO:K02046]
O5Y_17315  sulfate ABC transporter permease protein [KO:K02047]
O5Y_17310  sulfate ABC transporter ATP-binding protein [KO:K02045] [EC:7.3.2.3]
O5Y_23045  ABC transporter substrate-binding protein [KO:K15551]
O5Y_23050  ABC transporter permease [KO:K15552]
O5Y_23040  ABC transporter ATP-binding protein [KO:K10831] [EC:7.6.2.7]
O5Y_28175  aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
O5Y_28210  aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
O5Y_28180  aliphatic sulfonates ABC transporter permease protein [KO:K15554]
O5Y_28185  aliphatic sulfonates ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
O5Y_22050  molybdate ABC transporter molybdate-binding protein [KO:K02020]
O5Y_22045  molybdate ABC transporter permease [KO:K02018]
O5Y_22040  molybdate ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
O5Y_11735  2-aminoethylphosphonate ABC transporter substrate-binding protein [KO:K11081]
O5Y_11720  ABC transporter permease [KO:K11082]
O5Y_11725  2-aminoethylphosphonate transport system permease PhnU [KO:K11083]
O5Y_11730  ABC transporter ATP-binding protein [KO:K11084]
O5Y_19280  ABC transporter substrate-binding protein [KO:K05845]
O5Y_23270  ABC transporter substrate-binding protein [KO:K05845]
O5Y_19275  ABC transporter substrate-binding protein [KO:K05845]
O5Y_19290  ABC transporter permease [KO:K05846]
O5Y_19295  ABC transporter permease [KO:K05846]
O5Y_23255  ABC transporter permease [KO:K05846]
O5Y_23265  ABC transporter permease [KO:K05846]
O5Y_19285  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
O5Y_23260  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
O5Y_16945  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
O5Y_19360  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
O5Y_28420  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
O5Y_16960  ABC transporter substrate-binding protein [KO:K10227]
O5Y_16955  ABC transporter permease [KO:K10228]
O5Y_16950  ABC transporter permease [KO:K10229]
O5Y_28415  ABC transporter substrate-binding protein [KO:K10236]
O5Y_19375  ABC transporter substrate-binding protein [KO:K10236]
O5Y_28410  ABC transporter permease [KO:K10237]
O5Y_19370  ABC transporter permease [KO:K10237]
O5Y_19365  ABC transporter permease [KO:K10238]
O5Y_28405  ABC transporter permease [KO:K10238]
O5Y_03255  Mce family protein [KO:K02067]
O5Y_03260  Mce family protein [KO:K02067]
O5Y_03270  Mce family protein [KO:K02067]
O5Y_03275  Mce family protein [KO:K02067]
O5Y_04295  Mce family protein [KO:K02067]
O5Y_04300  Mce family protein [KO:K02067]
O5Y_04305  Mce family protein [KO:K02067]
O5Y_04310  Mce family protein [KO:K02067]
O5Y_04315  Mce family protein [KO:K02067]
O5Y_04320  Mce family protein [KO:K02067]
O5Y_08270  Mce family protein [KO:K02067]
O5Y_08275  Mce family protein [KO:K02067]
O5Y_08285  Mce family protein [KO:K02067]
O5Y_08290  Mce family protein [KO:K02067]
O5Y_22495  Mce family protein [KO:K02067]
O5Y_04020  Mce family protein [KO:K02067]
O5Y_04025  Mce family protein [KO:K02067]
O5Y_04035  Mce family protein [KO:K02067]
O5Y_15495  Mce family protein [KO:K02067]
O5Y_15500  Mce family protein [KO:K02067]
O5Y_15505  Mce family protein [KO:K02067]
O5Y_15510  Mce family protein [KO:K02067]
O5Y_15515  Mce family protein [KO:K02067]
O5Y_15520  Mce family protein [KO:K02067]
O5Y_04040  Mce family protein [KO:K02067]
O5Y_08265  Mce family protein [KO:K02067]
O5Y_08280  Mce family protein [KO:K02067]
O5Y_03265  Mce family protein [KO:K02067]
O5Y_03280  Mce family protein [KO:K02067]
O5Y_04030  Mce family protein [KO:K02067]
O5Y_04045  Mce family protein [KO:K02067]
O5Y_03285  YrbE family protein [KO:K02066]
O5Y_03290  YrbE family protein [KO:K02066]
O5Y_04285  YrbE family protein [KO:K02066]
O5Y_04290  YrbE family protein [KO:K02066]
O5Y_08255  YrbE family protein [KO:K02066]
O5Y_08260  YrbE family protein [KO:K02066]
O5Y_15525  YrbE family protein [KO:K02066]
O5Y_15530  YrbE family protein [KO:K02066]
O5Y_04050  YrbE family protein [KO:K02066]
O5Y_04055  YrbE family protein [KO:K02066]
O5Y_08250  ABC transporter ATP-binding protein [KO:K02065]
O5Y_25045  ABC transporter substrate-binding protein [KO:K10439]
O5Y_25035  ABC transporter permease [KO:K10440]
O5Y_25040  ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
O5Y_23560  ABC transporter substrate-binding protein [KO:K05813]
O5Y_23570  ABC transporter permease [KO:K05814]
O5Y_23565  ABC transporter permease [KO:K05815]
O5Y_23555  ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
O5Y_22755  phosphate ABC transporter substrate-binding protein [KO:K02040]
O5Y_22750  phosphate ABC transporter permease [KO:K02037]
O5Y_22745  phosphate ABC transporter permease [KO:K02038]
O5Y_22740  phosphate transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
O5Y_20460  glutamine ABC transporter glutamine-binding/permease protein [KO:K10036 K10037]
O5Y_20465  glutamine ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
O5Y_12670  glutamate ABC transporter glutamate-binding protein [KO:K10005]
O5Y_12665  glutamate ABC transporter permease protein [KO:K10006]
O5Y_12660  glutamate ABC transporter permease protein [KO:K10007]
O5Y_12675  glutamate ABC transporter ATP-binding protein [KO:K10008] [EC:7.4.2.1]
O5Y_07425  ABC transporter substrate-binding protein [KO:K01999]
O5Y_06370  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
O5Y_21070  ABC transporter substrate-binding protein [KO:K01999]
O5Y_15370  ABC transporter substrate-binding protein [KO:K01999]
O5Y_21080  ABC transporter permease [KO:K01997]
O5Y_06375  branched-chain amino acid ABC transporter permease protein [KO:K01997]
O5Y_08085  ABC transporter permease [KO:K01997 K01998]
O5Y_07430  ABC transporter permease [KO:K01997]
O5Y_15350  ABC transporter permease [KO:K01997]
O5Y_06380  branched-chain amino acid ABC transporter permease/ATP-binding protein [KO:K01995 K01998]
O5Y_15355  ABC transporter permease [KO:K01998]
O5Y_07435  ABC transporter permease [KO:K01998]
O5Y_07440  ABC transporter permease [KO:K01998]
O5Y_21075  ABC transporter permease [KO:K01998]
O5Y_21090  ABC transporter ATP-binding protein [KO:K01995]
O5Y_08090  ABC transporter ATP-binding protein [KO:K01995]
O5Y_07445  ABC transporter ATP-binding protein [KO:K01995]
O5Y_15360  ABC transporter ATP-binding protein [KO:K01995]
O5Y_07450  ABC transporter ATP-binding protein [KO:K01996]
O5Y_21085  ABC transporter ATP-binding protein [KO:K01996]
O5Y_08095  ABC transporter ATP-binding protein [KO:K01996]
O5Y_15365  ABC transporter ATP-binding protein [KO:K01996]
O5Y_06385  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
O5Y_24060  ABC transporter substrate-binding protein [KO:K02073]
O5Y_24070  ABC transporter permease [KO:K02072]
O5Y_24065  ABC transporter ATP-binding protein [KO:K02071]
O5Y_07415  ABC transporter substrate-binding protein [KO:K11959]
O5Y_02380  aliphatic amidase regulator [KO:K11959]
O5Y_28505  nitrile hydratase regulator 1 [KO:K11959]
O5Y_07410  ABC transporter permease [KO:K11960]
O5Y_07405  ABC transporter permease [KO:K11961]
O5Y_07400  ABC transporter ATP-binding protein [KO:K11962]
O5Y_07395  ABC transporter ATP-binding protein [KO:K11963]
O5Y_02395  ABC transporter substrate-binding protein [KO:K15580]
O5Y_02400  ABC transporter permease [KO:K15581]
O5Y_02405  ABC transporter permease [KO:K15582]
O5Y_02410  ABC transporter ATP-binding protein [KO:K10823 K15583]
O5Y_27410  iron-enterobactin transporter periplasmic binding protein [KO:K23185]
O5Y_12400  iron-siderophore binding protein [KO:K23185]
O5Y_04640  iron-enterobactin transporter periplasmic binding protein [KO:K23185]
O5Y_25710  iron-siderophore binding protein [KO:K25287]
O5Y_20340  ABC transporter substrate-binding protein [KO:K25287]
O5Y_11575  iron-siderophore binding protein [KO:K25286]
O5Y_17560  ABC transporter substrate-binding protein [KO:K25286]
O5Y_04580  ABC transporter substrate-binding protein [KO:K25286]
O5Y_00095  periplasmic binding protein [KO:K25286]
O5Y_11845  ABC transporter substrate-binding protein [KO:K25286]
O5Y_15850  ABC transporter substrate-binding protein [KO:K25286]
O5Y_13075  ABC transporter substrate-binding protein [KO:K25286]
O5Y_17340  ABC transporter substrate-binding protein [KO:K25286]
O5Y_27025  ABC transporter substrate-binding protein [KO:K25286]
O5Y_21830  iron-siderophore binding protein [KO:K25286]
O5Y_19670  ABC transporter substrate-binding protein [KO:K25286]
O5Y_07315  ABC transporter substrate-binding protein [KO:K25286]
O5Y_01520  iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
O5Y_11035  iron-siderophore binding protein [KO:K25286]
O5Y_04705  ABC transporter substrate-binding protein [KO:K25286]
O5Y_02190  iron-siderophore binding protein [KO:K25286]
O5Y_00775  ABC transporter substrate-binding protein [KO:K25286]
O5Y_04660  ABC transporter substrate-binding protein [KO:K25286]
O5Y_26000  ABC transporter substrate-binding protein [KO:K25286]
O5Y_01525  iron-siderophore ABC transporter permease protein [KO:K23186]
O5Y_14260  iron-siderophore ABC transporter permease protein [KO:K23186]
O5Y_20360  ABC transporter permease [KO:K23186]
O5Y_27405  iron-siderophore ABC transporter permease protein [KO:K23186]
O5Y_27400  iron-siderophore ABC transporter permease protein [KO:K23187]
O5Y_01530  iron-siderophore ABC transporter permease protein [KO:K23187]
O5Y_14255  iron-siderophore ABC transporter permease protein [KO:K23187]
O5Y_20355  ABC transporter permease [KO:K23187]
O5Y_27395  iron-siderophore ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
O5Y_01535  iron-siderophore ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
O5Y_14250  iron-siderophore ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
O5Y_20350  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
O5Y_28645  manganese ABC transporter manganese-binding protein [KO:K11601]
O5Y_28635  manganese ABC transporter permease protein [KO:K11602]
O5Y_28640  manganese ABC transporter ATP-binding protein [KO:K11603] [EC:7.2.2.5]
O5Y_12615  BioY protein [KO:K03523]
O5Y_12605  cobalt transport protein [KO:K16783]
O5Y_12610  ABC transporter ATP-binding protein [KO:K16784] [EC:7.6.2.-]
O5Y_12330  ABC transporter permease [KO:K16785]
O5Y_01285  O-antigen ABC transporter permease [KO:K09690]
O5Y_01280  ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
O5Y_00515  ABC transporter permease [KO:K09813]
O5Y_24370  ABC transporter permease [KO:K09813]
O5Y_24365  ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
O5Y_00520  ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
O5Y_10790  cell division protein FtsX [KO:K09811]
O5Y_10785  cell division protein FtsE [KO:K09812]
O5Y_20320  iron-siderophore ABC transporter permease/ATP-binding protein [KO:K14698] [EC:7.-.-.-]
O5Y_25500  iron-siderophore ABC transporter permease/ATP-binding protein [KO:K14698] [EC:7.-.-.-]
O5Y_20315  iron-siderophore ABC transporter permease/ATP-binding protein [KO:K14699] [EC:7.-.-.-]
O5Y_25495  iron-siderophore ABC transporter permease/ATP-binding protein [KO:K14699] [EC:7.-.-.-]
O5Y_01650  ABC transporter ATP-binding protein/permease [KO:K18887]
O5Y_06775  ABC transporter ATP-binding protein/permease [KO:K18887]
O5Y_01655  ABC transporter ATP-binding protein/permease [KO:K18888]
O5Y_06770  ABC transporter ATP-binding protein/permease [KO:K18888]
O5Y_22810  ABC transporter ATP-binding protein/permease [KO:K16012]
O5Y_22815  ABC transporter ATP-binding protein/permease [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
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