KEGG   PATHWAY: rze00980
Entry
rze00980                    Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Rhagoletis zephyria (snowberry fruit fly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rze00980  Metabolism of xenobiotics by cytochrome P450
rze00980

Organism
Rhagoletis zephyria (snowberry fruit fly) [GN:rze]
Gene
108376522  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
108367117  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
108367274  uncharacterized protein LOC108367274 [KO:K00799] [EC:2.5.1.18]
108377060  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
108368575  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
108377293  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108378168  glutathione S-transferase B-like [KO:K00799] [EC:2.5.1.18]
108378542  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108378543  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108379054  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
108370058  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108379253  glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]
108379443  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108379237  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108370618  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
108380211  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108361115  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108381280  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108381201  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108382343  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
108364371  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
108374995  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
108365443  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
108365444  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
108365448  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108365893  pyrimidodiazepine synthase [KO:K00799] [EC:2.5.1.18]
108355035  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
108354081  glutathione S-transferase D1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
108369393  glutathione S-transferase S1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
108357011  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
108363144  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase-like isoform X1 [KO:K00078] [EC:1.3.1.20 1.1.1.179]
108363146  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
108353932  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase-like [KO:K00078] [EC:1.3.1.20 1.1.1.179]
108367348  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
108377968  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
108369399  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
108369400  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
108369401  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
108369402  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
108369405  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
108369406  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
108379978  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
108380880  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
108371456  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108371458  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
108381934  UDP-glucuronosyltransferase 2B14-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108362437  UDP-glucuronosyltransferase 3A2 [KO:K00699] [EC:2.4.1.17]
108372620  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
108372621  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
108372622  UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
108372623  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
108363061  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
108363062  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
108364269  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
108364539  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108354732  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
108354743  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
108354753  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
108355087  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
108355097  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
108357826  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
108358050  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108359381  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108359609  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00129] [EC:1.2.1.5]
108373981  aldehyde dehydrogenase family 3 member B1-like [KO:K00129] [EC:1.2.1.5]
108378126  geraniol dehydrogenase-like [KO:K13951] [EC:1.1.1.1]
108369754  geraniol dehydrogenase-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
108371433  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
108372304  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   
LinkDB

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