KEGG PATHWAY: sac03440

KEGG

PATHWAY: sac03440

Entry

sac03440                    Pathway

Name

Homologous recombination - Staphylococcus aureus subsp. aureus COL (MRSA)

Description

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Class

Genetic Information Processing; Replication and repair

Pathway map

Homologous recombination

Other DBs

GO:

Organism

Staphylococcus aureus subsp. aureus COL (MRSA) [GN:sac]

Gene

recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]

ssb1; prophage L54a, single-stranded DNA binding protein [KO:K03111]

ssb2; single-stranded DNA-binding protein [KO:K03111]

single-stranded DNA-binding protein family [KO:K03111]

recF protein [KO:K03629]

DNA repair protein RecO family [KO:K03584]

recR; recombination protein RecR [KO:K06187]

recA protein [KO:K03553]

polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]

ruvA; Holliday junction DNA helicase RuvA [KO:K03550]

ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]

recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]

helicase, putative, RecD/TraA family [KO:K03581] [EC:3.1.11.5]

dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]

DNA polymerase III, alpha subunit, Gram-positive type [KO:K03763] [EC:2.7.7.7]

dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]

dnaX; DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]

holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]

DNA polymerase III, delta prime subunit, putative [KO:K02341] [EC:2.7.7.7]

exonuclease [KO:K02342] [EC:2.7.7.7]

priA; primosomal protein N` [KO:K04066] [EC:5.6.2.4]

Reference

Authors

Maloisel L, Fabre F, Gangloff S.

Title

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.

Journal

Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07

Reference

Authors

Haruta-Takahashi N, Iwasaki H.

Title

[Recombination mediators]

Journal

Seikagaku 79:449-53 (2007)

Reference

Authors

Ouyang KJ, Woo LL, Ellis NA.

Title

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.

Journal

Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003

Reference

Authors

Kawabata M, Kawabata T, Nishibori M.

Title

Role of recA/RAD51 family proteins in mammals.

Journal

Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987

Reference

Authors

Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.

Title

Mitotic recombination in Saccharomyces cerevisiae.

Journal

Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3

Reference

Authors

Heyer WD, Li X, Rolfsmeier M, Zhang XP.

Title

Rad54: the Swiss Army knife of homologous recombination?

Journal

Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481

Reference

Authors

Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.

Title

Recombination proteins and rescue of arrested replication forks.

Journal

DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016

KO pathway

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