KEGG   PATHWAY: snp02010
Entry
snp02010                    Pathway                                
Name
ABC transporters - Streptococcus pneumoniae AP200 (serotype 11A)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
snp02010  ABC transporters
snp02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Streptococcus pneumoniae AP200 (serotype 11A) [GN:snp]
Gene
SPAP_1822  ABC-type Fe3+ transport system, periplasmic component [KO:K02012]
SPAP_0292  ABC-type Fe3+ transport system, periplasmic component [KO:K02012]
SPAP_1820  ABC-type Fe3+ transport system, permease component [KO:K02011]
SPAP_0289  ABC-type Fe3+ transport system, permease component [KO:K02011]
SPAP_0290  ABC-type Fe3+ transport system, permease component [KO:K02011]
SPAP_1821  ABC-type spermidine/putrescine transport systems, ATPase component [KO:K02010] [EC:7.2.2.7]
SPAP_0291  ABC-type spermidine/putrescine transport systems, ATPase component [KO:K02010] [EC:7.2.2.7]
SPAP_1417  Spermidine/putrescine-binding periplasmic protein [KO:K11069]
SPAP_1418  ABC-type spermidine/putrescine transport system, permease component II [KO:K11070]
SPAP_1419  ABC-type spermidine/putrescine transport system, permease component I [KO:K11071]
SPAP_1420  ABC-type spermidine/putrescine transport systems, ATPase component [KO:K11072] [EC:7.6.2.11]
SPAP_1856  periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system [KO:K05845 K05846]
SPAP_1857  ABC-type proline/glycine betaine transport systems, ATPase component [KO:K05847] [EC:7.6.2.9]
SPAP_1601  ABC-type sugar transport systems, ATPase component [KO:K10112] [EC:7.5.2.-]
SPAP_2156  Maltose-binding periplasmic protein/domain [KO:K15770]
SPAP_2158  ABC-type sugar transport systems, permease component [KO:K15771]
SPAP_2157  ABC-type sugar transport systems, permease component [KO:K15771]
SPAP_2159  ABC-type maltose transport systems, permease component [KO:K15772]
SPAP_1895  ABC-type sugar transport system, periplasmic component [KO:K10117]
SPAP_1894  ABC-type sugar transport systems, permease component [KO:K10118]
SPAP_1893  ABC-type sugar transport system, permease component [KO:K10119]
SPAP_0136  hypothetical protein [KO:K17318]
SPAP_0134  ABC-type polysaccharide transport system, permease component [KO:K17319]
SPAP_0135  ABC-type sugar transport system, permease component [KO:K17320]
SPAP_0812  Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [KO:K07335]
SPAP_0814  ABC-type uncharacterized transport system, permease component [KO:K23535]
SPAP_0815  Uncharacterized ABC-type transport system, permease component [KO:K23536]
SPAP_0813  ABC-type uncharacterized transport systems, ATPase component [KO:K23537]
SPAP_1432  ABC-type phosphate transport system, periplasmic component [KO:K02040]
SPAP_2130  ABC-type phosphate transport system, periplasmic component [KO:K02040]
SPAP_1431  ABC-type phosphate transport system, permease component [KO:K02037]
SPAP_2131  ABC-type phosphate transport system, permease component [KO:K02037]
SPAP_1430  ABC-type phosphate transport system, permease component [KO:K02038]
SPAP_2132  ABC-type phosphate transport system, permease component [KO:K02038]
SPAP_1428  ABC-type phosphate transport system, ATPase component [KO:K02036] [EC:7.3.2.1]
SPAP_1429  ABC-type phosphate transport system, ATPase component [KO:K02036] [EC:7.3.2.1]
SPAP_2133  ABC-type phosphate transport system, ATPase component [KO:K02036] [EC:7.3.2.1]
SPAP_1265  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain protein [KO:K10036 K10037]
SPAP_1266  hypothetical protein [KO:K10038] [EC:7.4.2.1]
SPAP_0596  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain protein [KO:K10039]
SPAP_0594  ABC-type amino acid transport system, permease component [KO:K10040]
SPAP_0595  ABC-type amino acid transport system, permease component [KO:K10040]
SPAP_0597  ABC-type polar amino acid transport system, ATPase component [KO:K10041] [EC:7.4.2.1]
SPAP_0213  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain protein [KO:K02424]
SPAP_1489  ABC-type amino acid transport system, permease component [KO:K10009]
SPAP_1488  hypothetical protein [KO:K10010] [EC:7.4.2.1]
SPAP_1426  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain protein [KO:K23059]
SPAP_0792  ABC-type amino acid transport system, permease component [KO:K17077]
SPAP_0793  hypothetical protein [KO:K23060] [EC:7.4.2.1]
SPAP_0467  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain protein [KO:K17073 K17074]
SPAP_0466  ABC-type polar amino acid transport system, ATPase component [KO:K17076]
SPAP_0723  ABC-type branched-chain amino acid transport systems, periplasmic component [KO:K01999]
SPAP_0724  Branched-chain amino acid ABC-type transport system, permease component [KO:K01997]
SPAP_0725  ABC-type branched-chain amino acid transport system, permease component [KO:K01998]
SPAP_0726  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01995]
SPAP_0727  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01996]
SPAP_0214  ABC-type metal ion transport system, periplasmic component/surface antigen [KO:K02073]
SPAP_0217  ABC-type metal ion transport system, permease component [KO:K02072]
SPAP_0216  ABC-type metal ion transport system, ATPase component [KO:K02071]
SPAP_1550  hypothetical protein [KO:K15580]
SPAP_0390  ABC-type oligopeptide transport system, periplasmic component [KO:K15580]
SPAP_1889  ABC-type oligopeptide transport system, periplasmic component [KO:K15580]
SPAP_1888  ABC-type dipeptide/oligopeptide/nickel transport systems, permease component [KO:K15581]
SPAP_1887  ABC-type dipeptide/oligopeptide/nickel transport systems, permease component [KO:K15582]
SPAP_1886  ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [KO:K15583]
SPAP_1885  hypothetical protein [KO:K10823]
SPAP_1167  ABC-type Fe3+-hydroxamate transport system, periplasmic component [KO:K25286]
SPAP_1166  ABC-type Fe3+-siderophore transport system, permease component [KO:K23186]
SPAP_1165  ABC-type Fe3+-siderophore transport system, permease component [KO:K23187]
SPAP_1164  ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase component [KO:K23188] [EC:7.2.2.17 7.2.2.-]
SPAP_1038  ABC-type metal ion transport system, periplasmic component/surface adhesin [KO:K09815]
SPAP_2219  ABC-type metal ion transport system, periplasmic component/surface adhesin [KO:K09815]
SPAP_2220  ABC-type Mn2+/Zn2+ transport systems, permease component [KO:K09816]
SPAP_2221  ABC-type Mn/Zn transport systems, ATPase component [KO:K09817] [EC:7.2.2.20]
SPAP_1658  ABC-type metal ion transport system, periplasmic component/surface adhesin [KO:K19971]
SPAP_1657  ABC-type Mn2+/Zn2+ transport systems, permease component [KO:K19972]
SPAP_1656  ABC-type Mn/Zn transport systems, ATPase component [KO:K10830] [EC:7.2.2.5]
SPAP_0758  Uncharacterized conserved protein [KO:K03523]
SPAP_0490  ABC-type cobalt transport system, permease component CbiQ-like transporter [KO:K16785]
SPAP_2262  ABC-type cobalt transport system, permease component CbiQ-like transporter [KO:K16785]
SPAP_0697  hypothetical protein [KO:K16785]
SPAP_1468  ABC-type cobalt transport system, permease component CbiQ-like transporter [KO:K16785]
SPAP_2264  hypothetical protein [KO:K16786] [EC:7.-.-.-]
SPAP_2263  ABC-type cobalt transport system, ATPase component [KO:K16787] [EC:7.-.-.-]
SPAP_1768  ABC-type multidrug transport system, permease component [KO:K09694]
SPAP_1769  ABC-type multidrug transport system, ATPase component [KO:K09695]
SPAP_0943  ABC-type antimicrobial peptide transport system, permease component [KO:K19084]
SPAP_0942  ABC-type antimicrobial peptide transport system, ATPase component [KO:K19083]
SPAP_0731  Cell division protein [KO:K09811]
SPAP_0730  Predicted ATPase involved in cell division [KO:K09812]
SPAP_1465  ABC-type multidrug transport system, ATPase and permease component [KO:K14698] [EC:7.-.-.-]
SPAP_1466  ABC-type multidrug transport system, ATPase and permease component [KO:K14699] [EC:7.-.-.-]
SPAP_1834  ABC-type multidrug transport system, ATPase and permease component [KO:K18889]
SPAP_1833  ABC-type multidrug transport system, ATPase and permease component [KO:K18890]
SPAP_2121  ABC-type multidrug transport system, ATPase and permease component [KO:K18891]
SPAP_2119  ABC-type multidrug transport system, ATPase and permease component [KO:K18892]
SPAP_1388  ABC-type multidrug transport system, ATPase and permease component [KO:K18887]
SPAP_1387  ABC-type multidrug transport system, ATPase and permease component [KO:K18888]
SPAP_0091  ABC-type bacteriocin/lantibiotic exporter [KO:K12292] [EC:3.4.22.-]
SPAP_0529  ABC-type bacteriocin/lantibiotic exporter [KO:K20344]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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