KEGG   PATHWAY: spaa04138
Entry
spaa04138                   Pathway                                
Name
Autophagy - yeast - Spathaspora passalidarum
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
spaa04138  Autophagy - yeast
spaa04138

Other DBs
GO: 0006914
Organism
Spathaspora passalidarum [GN:spaa]
Gene
SPAPADRAFT_54778  hypothetical protein [KO:K07827]
SPAPADRAFT_67657  hypothetical protein [KO:K07827]
SPAPADRAFT_61383  hypothetical protein [KO:K04345] [EC:2.7.11.11]
SPAPADRAFT_136577  hypothetical protein [KO:K04345] [EC:2.7.11.11]
SPAPADRAFT_64707  hypothetical protein [KO:K21157] [EC:2.7.11.1]
SPAPADRAFT_61130  hypothetical protein [KO:K12761] [EC:2.7.11.1]
SPAPADRAFT_53808  hypothetical protein [KO:K08269] [EC:2.7.11.1]
SPAPADRAFT_49425  hypothetical protein [KO:K08331]
SPAPADRAFT_131523  autophagy related kinase activator Atg17 [KO:K08329]
SPAPADRAFT_51426  ATG9; hypothetical protein [KO:K17907]
SPAPADRAFT_151331  hypothetical protein [KO:K17906]
SPAPADRAFT_53098  autophagy-related protein 18 [KO:K17908]
SPAPADRAFT_48007  autophagy-related protein 21 [KO:K17908]
SPAPADRAFT_60081  autophagy-related protein 27 [KO:K21141]
SPAPADRAFT_72690  hypothetical protein [KO:K08330]
SPAPADRAFT_59180  hypothetical protein [KO:K17260]
SPAPADRAFT_60349  hypothetical protein [KO:K18584]
SPAPADRAFT_59474  hypothetical protein [KO:K05757]
SPAPADRAFT_58512  ARP2/3 complex 34 kDa subunit [KO:K05758]
SPAPADRAFT_63154  hypothetical protein [KO:K05756]
SPAPADRAFT_54639  hypothetical protein [KO:K05755]
SPAPADRAFT_59460  hypothetical protein [KO:K05754]
SPAPADRAFT_150965  hypothetical protein [KO:K19800] [EC:2.7.11.1]
SPAPADRAFT_60035  hypothetical protein [KO:K04464] [EC:2.7.11.24]
SPAPADRAFT_72021  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
SPAPADRAFT_59307  hypothetical protein [KO:K00654] [EC:2.3.1.50]
SPAPADRAFT_69614  Kontroller of growth [KO:K07204]
SPAPADRAFT_136422  1-phosphatidylinositol 3-kinase [KO:K07203] [EC:2.7.11.1]
SPAPADRAFT_133386  protein required for amino acid permease transport from the Golgi to the cell surface [KO:K08266]
SPAPADRAFT_142674  hypothetical protein [KO:K17606]
SPAPADRAFT_154183  hypothetical protein [KO:K04382] [EC:3.1.3.16]
SPAPADRAFT_142108  hypothetical protein [KO:K17607]
SPAPADRAFT_144352  hypothetical protein [KO:K12767] [EC:2.7.11.36]
SPAPADRAFT_57569  GCN2; putative eIF2-alpha kinase [KO:K16196] [EC:2.7.11.1]
SPAPADRAFT_58437  eukaryotic translation initiation factor 2 alpha subunit [KO:K03237]
SPAPADRAFT_60169  GCN4; hypothetical protein [KO:K09464]
SPAPADRAFT_58158  negative regulator of PHO system CaPho85 [KO:K06655] [EC:2.7.11.22]
SPAPADRAFT_142523  hypothetical protein [KO:K21197]
SPAPADRAFT_48369  hypothetical protein [KO:K09243]
SPAPADRAFT_48331  autophagy-related protein 8 [KO:K08341]
SPAPADRAFT_132815  hypothetical protein [KO:K08334]
SPAPADRAFT_142974  hypothetical protein [KO:K08333] [EC:2.7.11.1]
SPAPADRAFT_142747  hypothetical protein [KO:K00914] [EC:2.7.1.137]
SPAPADRAFT_137738  hypothetical protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]
SPAPADRAFT_134383  hypothetical protein [KO:K07756] [EC:2.7.4.21]
SPAPADRAFT_139029  hypothetical protein [KO:K18083] [EC:3.1.3.64 3.1.3.95]
SPAPADRAFT_139378  hypothetical protein [KO:K08336]
SPAPADRAFT_70290  hypothetical protein [KO:K08337]
SPAPADRAFT_132827  hypothetical protein [KO:K08339]
SPAPADRAFT_57808  hypothetical protein [KO:K08343]
SPAPADRAFT_59751  hypothetical protein [KO:K08342] [EC:3.4.22.-]
SPAPADRAFT_51624  hypothetical protein [KO:K21155]
SPAPADRAFT_63094  hypothetical protein [KO:K08502]
SPAPADRAFT_62124  hypothetical protein [KO:K08493]
SPAPADRAFT_57881  hypothetical protein [KO:K08516]
SPAPADRAFT_71938  vesicular-fusion protein SEC18 [KO:K06027] [EC:3.6.4.6]
SPAPADRAFT_59920  hypothetical protein [KO:K15296]
SPAPADRAFT_60274  hypothetical protein [KO:K07897]
SPAPADRAFT_57876  hypothetical protein [KO:K07897]
SPAPADRAFT_148912  hypothetical protein [KO:K20195]
SPAPADRAFT_63413  hypothetical protein [KO:K21156]
SPAPADRAFT_69768  hypothetical protein [KO:K20179]
SPAPADRAFT_132606  hypothetical protein [KO:K20180]
SPAPADRAFT_140331  hypothetical protein [KO:K20181]
SPAPADRAFT_136646  vacuolar sorting protein VPS33/slp1 [KO:K20182]
SPAPADRAFT_147568  hypothetical protein [KO:K20177]
SPAPADRAFT_56179  hypothetical protein [KO:K20178]
SPAPADRAFT_50087  hypothetical protein [KO:K20183]
SPAPADRAFT_153273  hypothetical protein [KO:K20184]
SPAPADRAFT_143323  hypothetical protein [KO:K12479]
SPAPADRAFT_60314  hypothetical protein [KO:K01381] [EC:3.4.23.25]
SPAPADRAFT_60277  hypothetical protein [KO:K01336] [EC:3.4.21.48 3.4.21.-]
SPAPADRAFT_65953  hypothetical protein [KO:K01336] [EC:3.4.21.48 3.4.21.-]
SPAPADRAFT_63540  hypothetical protein [KO:K01336] [EC:3.4.21.48 3.4.21.-]
SPAPADRAFT_57183  hypothetical protein [KO:K17900] [EC:3.1.1.3]
SPAPADRAFT_138769  hypothetical protein [KO:K14209]
SPAPADRAFT_140616  hypothetical protein [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
LinkDB

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