KEGG PATHWAY: spz03440

KEGG

PATHWAY: spz03440

Entry

spz03440                    Pathway

Name

Homologous recombination - Streptococcus pyogenes MGAS5005 (serotype M1)

Description

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Class

Genetic Information Processing; Replication and repair

Pathway map

Homologous recombination

Other DBs

GO:

Organism

Streptococcus pyogenes MGAS5005 (serotype M1) [GN:spz]

Gene

recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]

single-strand DNA binding protein [KO:K03111]

ssb2; phage single-strand DNA binding protein [KO:K03111]

ssb3; phage single-strand DNA binding protein [KO:K03111]

recF; DNA replication and repair protein [KO:K03629]

recO; DNA repair protein [KO:K03584]

recR; recombination protein [KO:K06187]

recA; RecA [KO:K03553]

polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]

ruvA; holliday junction DNA helicase [KO:K03550]

ruvB; holliday junction DNA helicase [KO:K03551] [EC:5.6.2.4]

recG; ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]

recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]

dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]

polC; DNA polymerase III alpha subunit [KO:K03763] [EC:2.7.7.7]

dnaN; DNA polymerase III beta chain [KO:K02338] [EC:2.7.7.7]

DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]

DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]

dnaX; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]

dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]

priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]

Reference

Authors

Maloisel L, Fabre F, Gangloff S.

Title

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.

Journal

Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07

Reference

Authors

Haruta-Takahashi N, Iwasaki H.

Title

[Recombination mediators]

Journal

Seikagaku 79:449-53 (2007)

Reference

Authors

Ouyang KJ, Woo LL, Ellis NA.

Title

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.

Journal

Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003

Reference

Authors

Kawabata M, Kawabata T, Nishibori M.

Title

Role of recA/RAD51 family proteins in mammals.

Journal

Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987

Reference

Authors

Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.

Title

Mitotic recombination in Saccharomyces cerevisiae.

Journal

Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3

Reference

Authors

Heyer WD, Li X, Rolfsmeier M, Zhang XP.

Title

Rad54: the Swiss Army knife of homologous recombination?

Journal

Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481

Reference

Authors

Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.

Title

Recombination proteins and rescue of arrested replication forks.

Journal

DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016

KO pathway

LinkDB

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