Entry
Name
ABC transporters - Thermobispora bispora
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Thermobispora bispora [GN:
tbi ]
Gene
Tbis_1322 Substrate-binding region of ABC-type glycine betaine transport system [KO:K15551 ]
Tbis_1323 binding-protein-dependent transport systems inner membrane component [KO:K15552 ]
Tbis_1378 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Tbis_1380 binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
Tbis_1556 binding-protein-dependent transport systems inner membrane component [KO:K15554 ]
Tbis_2690 molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
Tbis_1012 binding-protein-dependent transport systems inner membrane component [KO:K11070 ]
Tbis_1011 binding-protein-dependent transport systems inner membrane component [KO:K11071 ]
Tbis_1134 Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002 ]
Tbis_1885 binding-protein-dependent transport systems inner membrane component [KO:K15771 ]
Tbis_1884 binding-protein-dependent transport systems inner membrane component [KO:K15772 ]
Tbis_3250 binding-protein-dependent transport systems inner membrane component [KO:K10118 ]
Tbis_2414 binding-protein-dependent transport systems inner membrane component [KO:K10118 ]
Tbis_0068 binding-protein-dependent transport systems inner membrane component [KO:K10118 ]
Tbis_2413 binding-protein-dependent transport systems inner membrane component [KO:K10119 ]
Tbis_0067 binding-protein-dependent transport systems inner membrane component [KO:K10119 ]
Tbis_3249 binding-protein-dependent transport systems inner membrane component [KO:K10119 ]
Tbis_0868 binding-protein-dependent transport systems inner membrane component [KO:K10233 ]
Tbis_0867 binding-protein-dependent transport systems inner membrane component [KO:K10234 ]
Tbis_1561 ABC-type sugar transport system periplasmic component-like protein [KO:K17318 ]
Tbis_1563 binding-protein-dependent transport systems inner membrane component [KO:K17319 ]
Tbis_1562 binding-protein-dependent transport systems inner membrane component [KO:K17320 ]
Tbis_0841 binding-protein-dependent transport systems inner membrane component [KO:K10241 ]
Tbis_1892 binding-protein-dependent transport systems inner membrane component [KO:K10241 ]
Tbis_1893 binding-protein-dependent transport systems inner membrane component [KO:K10242 ]
Tbis_0840 binding-protein-dependent transport systems inner membrane component [KO:K10242 ]
Tbis_1104 binding-protein-dependent transport systems inner membrane component [KO:K17330 ]
Tbis_1103 binding-protein-dependent transport systems inner membrane component [KO:K17331 ]
Tbis_2582 periplasmic binding protein/LacI transcriptional regulator [KO:K10439 ]
Tbis_2882 periplasmic binding protein/LacI transcriptional regulator [KO:K10439 ]
Tbis_1217 ABC-type xylose transport system periplasmic component-like protein [KO:K10543 ]
Tbis_2933 phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040 ]
Tbis_2934 phosphate ABC transporter, inner membrane subunit PstC [KO:K02037 ]
Tbis_2935 phosphate ABC transporter, inner membrane subunit PstA [KO:K02038 ]
Tbis_1123 polar amino acid ABC transporter, inner membrane subunit [KO:K10006 ]
Tbis_1122 polar amino acid ABC transporter, inner membrane subunit [KO:K10007 ]
Tbis_1907 binding-protein-dependent transport systems inner membrane component [KO:K02072 ]
Tbis_3310 binding-protein-dependent transport systems inner membrane component [KO:K15581 ]
Tbis_3309 binding-protein-dependent transport systems inner membrane component [KO:K15582 ]
Tbis_3308 oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583 ]
Tbis_3307 oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823 ]
Tbis_2747 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012 ]
Tbis_2748 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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