KEGG   PATHWAY: that03070
Entry
that03070                   Pathway                                
Name
Bacterial secretion system - Thalassomonas haliotis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
that03070  Bacterial secretion system
that03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Thalassomonas haliotis [GN:that]
Gene
H3N35_06040  tolC; outer membrane channel protein TolC [KO:K12340]
H3N35_06870  TolC family protein [KO:K12340]
H3N35_13880  sctC; type III secretion system outer membrane ring subunit SctC [KO:K03219]
H3N35_13930  sctW; type III secretion system gatekeeper subunit SctW [KO:K04058]
H3N35_13850  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
H3N35_13990  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
H3N35_13995  sctS; type III secretion system export apparatus subunit SctS [KO:K03227]
H3N35_14000  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
H3N35_14005  sctU; type III secretion system export apparatus subunit SctU [KO:K03229]
H3N35_13910  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
H3N35_13940  sctN; type III secretion system ATPase SctN [KO:K03224] [EC:7.4.2.8]
H3N35_13985  sctQ; type III secretion system cytoplasmic ring protein SctQ [KO:K03225]
H3N35_13840  sctL; type III secretion system stator protein SctL [KO:K03223]
H3N35_26100  gspD; type II secretion system secretin GspD [KO:K02453]
H3N35_26105  gspC; type II secretion system protein GspC [KO:K02452]
H3N35_26090  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
H3N35_26085  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
H3N35_07435  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
H3N35_26080  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
H3N35_26075  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
H3N35_26070  gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459]
H3N35_26065  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
H3N35_26060  gspL; type II secretion system protein GspL [KO:K02461]
H3N35_26055  type II secretion system protein M [KO:K02462]
H3N35_26095  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
H3N35_07440  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
H3N35_24390  secD; protein translocase subunit SecD [KO:K03072]
H3N35_05190  secD; protein translocase subunit SecD [KO:K03072]
H3N35_24385  secF; protein translocase subunit SecF [KO:K03074]
H3N35_05195  secF; protein translocase subunit SecF [KO:K03074]
H3N35_25555  secE; preprotein translocase subunit SecE [KO:K03073]
H3N35_11115  secG; preprotein translocase subunit SecG [KO:K03075]
H3N35_25365  secY; preprotein translocase subunit SecY [KO:K03076]
H3N35_05185  yajC; preprotein translocase subunit YajC [KO:K03210]
H3N35_27645  yidC; membrane protein insertase YidC [KO:K03217]
H3N35_23855  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
H3N35_26980  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
H3N35_01955  secB; protein-export chaperone SecB [KO:K03071]
H3N35_05575  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
H3N35_26950  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
H3N35_26945  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
H3N35_26940  tatC; twin-arginine translocase subunit TatC [KO:K03118]
H3N35_10855  tssI; type VI secretion system tip protein VgrG [KO:K11904]
H3N35_12420  tssI; type VI secretion system tip protein VgrG [KO:K11904]
H3N35_00335  tssI; type VI secretion system tip protein VgrG [KO:K11904]
H3N35_10850  type VI secretion system tube protein Hcp [KO:K11903]
H3N35_12395  type VI secretion system tube protein Hcp [KO:K11903]
H3N35_00235  type VI secretion system tube protein Hcp [KO:K11903]
H3N35_10775  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
H3N35_14270  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
H3N35_10790  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
H3N35_00300  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
H3N35_14255  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
H3N35_10785  tssL; type VI secretion system protein TssL [KO:K11892]
H3N35_14260  DotU family type IV/VI secretion system protein [KO:K11892]
H3N35_10845  tssH; type VI secretion system ATPase TssH [KO:K11907]
H3N35_12370  tssH; type VI secretion system ATPase TssH [KO:K11907]
H3N35_00270  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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