KEGG   PATHWAY: ypj03070
Entry
ypj03070                    Pathway                                
Name
Bacterial secretion system - Yersinia pestis Harbin35
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ypj03070  Bacterial secretion system
ypj03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Yersinia pestis Harbin35 [GN:ypj]
Gene
CH55_2150  type I secretion outer membrane, TolC family protein [KO:K12340]
CH55_3502  eprI; type III secretion apparatus needle protein [KO:K03221]
CH55_4372  eprI; type III secretion apparatus needle protein [KO:K03221]
CH55_4291  type III secretion YscO family protein [KO:K04056]
CH55_4290  type III secretion system needle length determinant [KO:K04057]
CH55_4297  type III secretion protein, YscX family [KO:K04059]
CH55_4278  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
CH55_3506  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
CH55_4294  type III secretion regulator YopN/LcrE/InvE/MxiC [KO:K04058]
CH55_3499  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
CH55_4368  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
CH55_3490  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
CH55_4288  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
CH55_3489  type III secretion, HrpO family protein [KO:K03227]
CH55_4287  type III secretion, HrpO family protein [KO:K03227]
CH55_3488  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
CH55_4286  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
CH55_3487  escU; escU [KO:K03229]
CH55_4285  yscU; yop s translocation protein U [KO:K03229]
CH55_3495  FHIPEP family protein [KO:K03230]
CH55_3496  FHIPEP family protein [KO:K03230]
CH55_4299  type III secretion, HrcV family protein [KO:K03230]
CH55_3494  ATPase, FliI/YscN family protein [KO:K03224] [EC:7.4.2.8]
CH55_4292  ATPase, FliI/YscN family protein [KO:K03224] [EC:7.4.2.8]
CH55_3491  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
CH55_4289  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
CH55_4366  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
CH55_3724  gspD; type II secretion system protein D [KO:K02453]
CH55_3736  bacterial chaperone lipo family protein [KO:K02465]
CH55_3723  type IV pilus biogenesis family protein [KO:K02452]
CH55_3727  type II secretion system (T2SS), F family protein [KO:K02455]
CH55_3728  gspG; type II secretion system protein G [KO:K02456]
CH55_3729  hypothetical protein [KO:K02457]
CH55_3730  type II secretion system (T2SS), I family protein [KO:K02458]
CH55_3731  gspJ; type II secretion system protein J [KO:K02459]
CH55_3732  type II secretion system (T2SS), K family protein [KO:K02460]
CH55_3733  gspL; type II secretion system protein L [KO:K02461]
CH55_3725  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
CH55_3735  outO; type 4 prepilin-like proteins leader peptide-processing enzyme [KO:K02464] [EC:3.4.23.43 2.1.1.-]
CH55_1766  secD; export membrane protein SecD [KO:K03072]
CH55_1765  secF; export membrane protein secF [KO:K03074]
CH55_3273  secE; preprotein translocase, SecE subunit [KO:K03073]
CH55_3335  secG; preprotein translocase, SecG subunit [KO:K03075]
CH55_2968  secY; preprotein translocase, SecY subunit [KO:K03076]
CH55_1767  yajC; preprotein translocase, YajC subunit [KO:K03210]
CH55_2784  yidC; membrane protein insertase, YidC/Oxa1 family [KO:K03217]
CH55_2301  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
CH55_2300  secretion monitor family protein [KO:K13301]
CH55_3201  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
CH55_3028  secB; protein-export chaperone SecB [KO:K03071]
CH55_1872  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
CH55_3238  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
CH55_3239  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
CH55_3240  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
CH55_1579  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03425]
CH55_693  shlB; hemolysin transporter protein shlB [KO:K11017]
CH55_2840  shlB; hemolysin transporter protein shlB [KO:K11017]
CH55_2839  shlA; hemolysin [KO:K11016]
CH55_691  hemagluttinin repeat family protein [KO:K11016]
CH55_692  hypothetical protein [KO:K11016]
CH55_4341  yadA; adhesin yadA [KO:K12341]
CH55_1155  hypothetical protein [KO:K12342]
CH55_1156  coiled stalk of trimeric autotransporter adhesin family protein [KO:K12342]
CH55_1066  Rhs element Vgr family protein [KO:K11904]
CH55_2588  Rhs element Vgr family protein [KO:K11904]
CH55_2597  Rhs element Vgr family protein [KO:K11904]
CH55_3535  Rhs element Vgr family protein [KO:K11904]
CH55_3570  Rhs element Vgr family protein [KO:K11904]
CH55_2249  Rhs element Vgr family protein [KO:K11904]
CH55_4151  Rhs element Vgr family protein [KO:K11904]
CH55_1068  type VI secretion system effector, Hcp1 family protein [KO:K11903]
CH55_3568  type VI secretion system effector, Hcp1 family protein [KO:K11903]
CH55_2852  type VI secretion system effector, Hcp1 family protein [KO:K11903]
CH55_2244  hypothetical protein [KO:K11903]
CH55_4142  type VI secretion system effector, Hcp1 family protein [KO:K11903]
CH55_1051  type VI secretion lipofamily protein [KO:K11906]
CH55_2607  type VI secretion lipofamily protein [KO:K11906]
CH55_2254  type VI secretion lipofamily protein [KO:K11906]
CH55_4143  type VI secretion lipofamily protein [KO:K11906]
CH55_1058  intracellular multiplication and macrophage-killing family protein [KO:K11891]
CH55_2600  intracellular multiplication and macrophage-killing family protein [KO:K11891]
CH55_2258  intracellular multiplication and macrophage-killing family protein [KO:K11891]
CH55_4150  intracellular multiplication and macrophage-killing family protein [KO:K11891]
CH55_1070  type IV/VI secretion system, DotU family domain protein [KO:K11892]
CH55_2605  type IV/VI secretion system, DotU family domain protein [KO:K11892]
CH55_3566  type IV/VI secretion system, DotU family domain protein [KO:K11892]
CH55_2256  hypothetical protein [KO:K11892]
CH55_2257  ompA family protein [KO:K11892]
CH55_4149  type VI secretion system peptidoglycan-associated domain protein [KO:K11892]
CH55_4145  type IV/VI secretion system, DotU family domain protein [KO:K11892]
CH55_1067  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
CH55_2604  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
CH55_3569  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
CH55_2248  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
CH55_4132  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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