KEGG   PATHWAY: zro04138
Entry
zro04138                    Pathway                                
Name
Autophagy - yeast - Zygosaccharomyces rouxii
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
zro04138  Autophagy - yeast
zro04138

Other DBs
GO: 0006914
Organism
Zygosaccharomyces rouxii [GN:zro]
Gene
ZYRO0B09438g  hypothetical protein [KO:K07827]
ZYRO0G18502g  hypothetical protein [KO:K04345] [EC:2.7.11.11]
ZYRO0G08844g  hypothetical protein [KO:K04345] [EC:2.7.11.11]
ZYRO0F01034g  hypothetical protein [KO:K16314] [EC:2.7.11.1]
ZYRO0G19052g  hypothetical protein [KO:K21157] [EC:2.7.11.1]
ZYRO0A05544g  hypothetical protein [KO:K12761] [EC:2.7.11.1]
ZYRO0G19074g  hypothetical protein [KO:K08269] [EC:2.7.11.1]
ZYRO0D00924g  hypothetical protein [KO:K08331]
ZYRO0B13618g  hypothetical protein [KO:K08329]
ZYRO0A03454g  hypothetical protein [KO:K21144]
ZYRO0F07744g  hypothetical protein [KO:K21143]
ZYRO0F11264g  hypothetical protein [KO:K17907]
ZYRO0F15730g  hypothetical protein [KO:K17906]
ZYRO0F14850g  hypothetical protein [KO:K17908]
ZYRO0G00946g  hypothetical protein [KO:K17908]
ZYRO0B13882g  hypothetical protein [KO:K17909]
ZYRO0D16940g  hypothetical protein [KO:K21141]
ZYRO0C15686g  hypothetical protein [KO:K08330]
ZYRO0B04928g  hypothetical protein [KO:K17260]
ZYRO0G01936g  hypothetical protein [KO:K18584]
ZYRO0C14762g  hypothetical protein [KO:K05757]
ZYRO0D07942g  hypothetical protein [KO:K05758]
ZYRO0B07502g  hypothetical protein [KO:K05756]
ZYRO0E00660g  hypothetical protein [KO:K05755]
ZYRO0C08426g  hypothetical protein [KO:K05754]
ZYRO0G00506g  hypothetical protein [KO:K19800] [EC:2.7.11.1]
ZYRO0G16082g  hypothetical protein [KO:K04464] [EC:2.7.11.24]
ZYRO0D07282g  hypothetical protein [KO:K00654] [EC:2.3.1.50]
ZYRO0G09152g  hypothetical protein [KO:K00654] [EC:2.3.1.50]
ZYRO0D07744g  hypothetical protein [KO:K07204]
ZYRO0G01958g  hypothetical protein [KO:K07203] [EC:2.7.11.1]
ZYRO0E04620g  hypothetical protein [KO:K08266]
ZYRO0E06644g  hypothetical protein [KO:K17606]
ZYRO0F05610g  hypothetical protein [KO:K04382] [EC:3.1.3.16]
ZYRO0G17336g  hypothetical protein [KO:K17607]
ZYRO0F03014g  hypothetical protein [KO:K12767] [EC:2.7.11.36]
ZYRO0F01012g  hypothetical protein [KO:K09468]
ZYRO0G16632g  hypothetical protein [KO:K16196] [EC:2.7.11.1]
ZYRO0G12056g  hypothetical protein [KO:K03237]
ZYRO0D09174g  hypothetical protein [KO:K09464]
ZYRO0F08074g  hypothetical protein [KO:K06655] [EC:2.7.11.22]
ZYRO0C14454g  hypothetical protein [KO:K21197]
ZYRO0C04686g  hypothetical protein [KO:K09243]
ZYRO0B03542g  hypothetical protein [KO:K08341]
ZYRO0F10978g  hypothetical protein [KO:K08334]
ZYRO0C17006g  hypothetical protein [KO:K08335]
ZYRO0F11198g  hypothetical protein [KO:K21145]
ZYRO0C15884g  hypothetical protein [KO:K08333] [EC:2.7.11.1]
ZYRO0C04356g  hypothetical protein [KO:K00914] [EC:2.7.1.137]
ZYRO0F14542g  hypothetical protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]
ZYRO0A03674g  hypothetical protein [KO:K07756] [EC:2.7.4.21]
ZYRO0G18062g  hypothetical protein [KO:K18083] [EC:3.1.3.64 3.1.3.95]
ZYRO0C04862g  hypothetical protein [KO:K08336]
ZYRO0C11726g  hypothetical protein [KO:K08337]
ZYRO0G07766g  hypothetical protein [KO:K08338]
ZYRO0F07150g  hypothetical protein [KO:K08339]
ZYRO0A07590g  hypothetical protein [KO:K08340]
ZYRO0C05500g  hypothetical protein [KO:K08343]
ZYRO0F15334g  hypothetical protein [KO:K08342] [EC:3.4.22.-]
ZYRO0B09614g  hypothetical protein [KO:K21155]
ZYRO0E08580g  hypothetical protein [KO:K08502]
ZYRO0C05720g  hypothetical protein [KO:K08493]
ZYRO0B13684g  hypothetical protein [KO:K08516]
ZYRO0G12738g  hypothetical protein [KO:K06027] [EC:3.6.4.6]
ZYRO0G18106g  hypothetical protein [KO:K15296]
ZYRO0C07700g  hypothetical protein [KO:K07897]
ZYRO0E01716g  hypothetical protein [KO:K20195]
ZYRO0C17160g  hypothetical protein [KO:K21156]
ZYRO0G15642g  hypothetical protein [KO:K20179]
ZYRO0F08338g  hypothetical protein [KO:K20180]
ZYRO0F14234g  hypothetical protein [KO:K20181]
ZYRO0B12584g  hypothetical protein [KO:K20182]
ZYRO0B06644g  hypothetical protein [KO:K20177]
ZYRO0G10670g  hypothetical protein [KO:K20178]
ZYRO0B12958g  hypothetical protein [KO:K20183]
ZYRO0B11264g  hypothetical protein [KO:K20184]
ZYRO0G03520g  hypothetical protein [KO:K12479]
ZYRO0F07392g  hypothetical protein [KO:K01381] [EC:3.4.23.25]
ZYRO0C07942g  hypothetical protein [KO:K01336] [EC:3.4.21.48 3.4.21.-]
ZYRO0D08338g  hypothetical protein [KO:K17900] [EC:3.1.1.3]
ZYRO0F17820g  hypothetical protein [KO:K06902]
ZYRO0A10538g  hypothetical protein [KO:K14209]
ZYRO0B09548g  hypothetical protein [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
LinkDB

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