KEGG   Prionailurus bengalensis (leopard cat): 122487093
Entry
122487093         CDS       T07574                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg01521  EGFR tyrosine kinase inhibitor resistance
pbg01522  Endocrine resistance
pbg01524  Platinum drug resistance
pbg04012  ErbB signaling pathway
pbg04014  Ras signaling pathway
pbg04015  Rap1 signaling pathway
pbg04024  cAMP signaling pathway
pbg04062  Chemokine signaling pathway
pbg04066  HIF-1 signaling pathway
pbg04068  FoxO signaling pathway
pbg04070  Phosphatidylinositol signaling system
pbg04071  Sphingolipid signaling pathway
pbg04072  Phospholipase D signaling pathway
pbg04081  Hormone signaling
pbg04140  Autophagy - animal
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04152  AMPK signaling pathway
pbg04210  Apoptosis
pbg04211  Longevity regulating pathway
pbg04213  Longevity regulating pathway - multiple species
pbg04218  Cellular senescence
pbg04360  Axon guidance
pbg04370  VEGF signaling pathway
pbg04380  Osteoclast differentiation
pbg04510  Focal adhesion
pbg04550  Signaling pathways regulating pluripotency of stem cells
pbg04611  Platelet activation
pbg04613  Neutrophil extracellular trap formation
pbg04620  Toll-like receptor signaling pathway
pbg04625  C-type lectin receptor signaling pathway
pbg04630  JAK-STAT signaling pathway
pbg04650  Natural killer cell mediated cytotoxicity
pbg04660  T cell receptor signaling pathway
pbg04662  B cell receptor signaling pathway
pbg04664  Fc epsilon RI signaling pathway
pbg04666  Fc gamma R-mediated phagocytosis
pbg04668  TNF signaling pathway
pbg04670  Leukocyte transendothelial migration
pbg04722  Neurotrophin signaling pathway
pbg04725  Cholinergic synapse
pbg04750  Inflammatory mediator regulation of TRP channels
pbg04810  Regulation of actin cytoskeleton
pbg04910  Insulin signaling pathway
pbg04914  Progesterone-mediated oocyte maturation
pbg04915  Estrogen signaling pathway
pbg04917  Prolactin signaling pathway
pbg04919  Thyroid hormone signaling pathway
pbg04923  Regulation of lipolysis in adipocytes
pbg04926  Relaxin signaling pathway
pbg04929  GnRH secretion
pbg04930  Type II diabetes mellitus
pbg04931  Insulin resistance
pbg04932  Non-alcoholic fatty liver disease
pbg04933  AGE-RAGE signaling pathway in diabetic complications
pbg04935  Growth hormone synthesis, secretion and action
pbg04960  Aldosterone-regulated sodium reabsorption
pbg04973  Carbohydrate digestion and absorption
pbg05010  Alzheimer disease
pbg05017  Spinocerebellar ataxia
pbg05020  Prion disease
pbg05100  Bacterial invasion of epithelial cells
pbg05135  Yersinia infection
pbg05142  Chagas disease
pbg05146  Amoebiasis
pbg05160  Hepatitis C
pbg05161  Hepatitis B
pbg05162  Measles
pbg05163  Human cytomegalovirus infection
pbg05164  Influenza A
pbg05165  Human papillomavirus infection
pbg05166  Human T-cell leukemia virus 1 infection
pbg05167  Kaposi sarcoma-associated herpesvirus infection
pbg05168  Herpes simplex virus 1 infection
pbg05169  Epstein-Barr virus infection
pbg05170  Human immunodeficiency virus 1 infection
pbg05171  Coronavirus disease - COVID-19
pbg05200  Pathways in cancer
pbg05203  Viral carcinogenesis
pbg05205  Proteoglycans in cancer
pbg05206  MicroRNAs in cancer
pbg05207  Chemical carcinogenesis - receptor activation
pbg05208  Chemical carcinogenesis - reactive oxygen species
pbg05210  Colorectal cancer
pbg05211  Renal cell carcinoma
pbg05212  Pancreatic cancer
pbg05213  Endometrial cancer
pbg05214  Glioma
pbg05215  Prostate cancer
pbg05218  Melanoma
pbg05220  Chronic myeloid leukemia
pbg05221  Acute myeloid leukemia
pbg05222  Small cell lung cancer
pbg05223  Non-small cell lung cancer
pbg05224  Breast cancer
pbg05225  Hepatocellular carcinoma
pbg05226  Gastric cancer
pbg05230  Central carbon metabolism in cancer
pbg05231  Choline metabolism in cancer
pbg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pbg05415  Diabetic cardiomyopathy
pbg05417  Lipid and atherosclerosis
pbg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122487093 (PIK3R2)
   04014 Ras signaling pathway
    122487093 (PIK3R2)
   04015 Rap1 signaling pathway
    122487093 (PIK3R2)
   04370 VEGF signaling pathway
    122487093 (PIK3R2)
   04630 JAK-STAT signaling pathway
    122487093 (PIK3R2)
   04668 TNF signaling pathway
    122487093 (PIK3R2)
   04066 HIF-1 signaling pathway
    122487093 (PIK3R2)
   04068 FoxO signaling pathway
    122487093 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    122487093 (PIK3R2)
   04072 Phospholipase D signaling pathway
    122487093 (PIK3R2)
   04071 Sphingolipid signaling pathway
    122487093 (PIK3R2)
   04024 cAMP signaling pathway
    122487093 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    122487093 (PIK3R2)
   04152 AMPK signaling pathway
    122487093 (PIK3R2)
   04150 mTOR signaling pathway
    122487093 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122487093 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122487093 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    122487093 (PIK3R2)
   04218 Cellular senescence
    122487093 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122487093 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    122487093 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122487093 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122487093 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    122487093 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    122487093 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    122487093 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    122487093 (PIK3R2)
   04660 T cell receptor signaling pathway
    122487093 (PIK3R2)
   04662 B cell receptor signaling pathway
    122487093 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    122487093 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    122487093 (PIK3R2)
   04670 Leukocyte transendothelial migration
    122487093 (PIK3R2)
   04062 Chemokine signaling pathway
    122487093 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122487093 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    122487093 (PIK3R2)
   04929 GnRH secretion
    122487093 (PIK3R2)
   04915 Estrogen signaling pathway
    122487093 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    122487093 (PIK3R2)
   04917 Prolactin signaling pathway
    122487093 (PIK3R2)
   04926 Relaxin signaling pathway
    122487093 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    122487093 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    122487093 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122487093 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122487093 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    122487093 (PIK3R2)
   04722 Neurotrophin signaling pathway
    122487093 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122487093 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    122487093 (PIK3R2)
   04380 Osteoclast differentiation
    122487093 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    122487093 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    122487093 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122487093 (PIK3R2)
   05206 MicroRNAs in cancer
    122487093 (PIK3R2)
   05205 Proteoglycans in cancer
    122487093 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    122487093 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    122487093 (PIK3R2)
   05203 Viral carcinogenesis
    122487093 (PIK3R2)
   05230 Central carbon metabolism in cancer
    122487093 (PIK3R2)
   05231 Choline metabolism in cancer
    122487093 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122487093 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122487093 (PIK3R2)
   05212 Pancreatic cancer
    122487093 (PIK3R2)
   05225 Hepatocellular carcinoma
    122487093 (PIK3R2)
   05226 Gastric cancer
    122487093 (PIK3R2)
   05214 Glioma
    122487093 (PIK3R2)
   05221 Acute myeloid leukemia
    122487093 (PIK3R2)
   05220 Chronic myeloid leukemia
    122487093 (PIK3R2)
   05218 Melanoma
    122487093 (PIK3R2)
   05211 Renal cell carcinoma
    122487093 (PIK3R2)
   05215 Prostate cancer
    122487093 (PIK3R2)
   05213 Endometrial cancer
    122487093 (PIK3R2)
   05224 Breast cancer
    122487093 (PIK3R2)
   05222 Small cell lung cancer
    122487093 (PIK3R2)
   05223 Non-small cell lung cancer
    122487093 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122487093 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    122487093 (PIK3R2)
   05161 Hepatitis B
    122487093 (PIK3R2)
   05160 Hepatitis C
    122487093 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    122487093 (PIK3R2)
   05164 Influenza A
    122487093 (PIK3R2)
   05162 Measles
    122487093 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    122487093 (PIK3R2)
   05163 Human cytomegalovirus infection
    122487093 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122487093 (PIK3R2)
   05169 Epstein-Barr virus infection
    122487093 (PIK3R2)
   05165 Human papillomavirus infection
    122487093 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    122487093 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    122487093 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122487093 (PIK3R2)
   05142 Chagas disease
    122487093 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122487093 (PIK3R2)
   05017 Spinocerebellar ataxia
    122487093 (PIK3R2)
   05020 Prion disease
    122487093 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122487093 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    122487093 (PIK3R2)
   05415 Diabetic cardiomyopathy
    122487093 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122487093 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    122487093 (PIK3R2)
   04931 Insulin resistance
    122487093 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122487093 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122487093 (PIK3R2)
   01524 Platinum drug resistance
    122487093 (PIK3R2)
   01522 Endocrine resistance
    122487093 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pbg04131]
    122487093 (PIK3R2)
Membrane trafficking [BR:pbg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122487093 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 122487093
NCBI-ProteinID: XP_043442981
LinkDB
Position
A2:13652418..13665259
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPEPPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgagcagccctgcaggtg
ctgggcgtggccgagggcaacgagcgctgcccacagagcgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagagcagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagccgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctggtggagaagttgcttcaggaacatctggaagagcaggaggtcgcgcccccagcgctg
ccacccaaaccccccaaggccaagccagcccccgcaggcctagccaatggggggagcccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccgctcaccttctgctccgttgtggacctcatc
acccactaccgccacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacgcaagagaagtgtagc
aaggagtatctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gagcaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaggctgaggaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctccgtggtggtggac
ggcgacaccaagcactgtgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgcgggcccccgggcccggg
cccccgccagccacccgctga

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