KEGG   Prionailurus bengalensis (leopard cat): 122489641
Entry
122489641         CDS       T07574                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg01521  EGFR tyrosine kinase inhibitor resistance
pbg01522  Endocrine resistance
pbg01524  Platinum drug resistance
pbg04012  ErbB signaling pathway
pbg04014  Ras signaling pathway
pbg04015  Rap1 signaling pathway
pbg04024  cAMP signaling pathway
pbg04062  Chemokine signaling pathway
pbg04066  HIF-1 signaling pathway
pbg04068  FoxO signaling pathway
pbg04070  Phosphatidylinositol signaling system
pbg04071  Sphingolipid signaling pathway
pbg04072  Phospholipase D signaling pathway
pbg04081  Hormone signaling
pbg04140  Autophagy - animal
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04152  AMPK signaling pathway
pbg04210  Apoptosis
pbg04211  Longevity regulating pathway
pbg04213  Longevity regulating pathway - multiple species
pbg04218  Cellular senescence
pbg04360  Axon guidance
pbg04370  VEGF signaling pathway
pbg04380  Osteoclast differentiation
pbg04510  Focal adhesion
pbg04550  Signaling pathways regulating pluripotency of stem cells
pbg04611  Platelet activation
pbg04613  Neutrophil extracellular trap formation
pbg04620  Toll-like receptor signaling pathway
pbg04625  C-type lectin receptor signaling pathway
pbg04630  JAK-STAT signaling pathway
pbg04650  Natural killer cell mediated cytotoxicity
pbg04660  T cell receptor signaling pathway
pbg04662  B cell receptor signaling pathway
pbg04664  Fc epsilon RI signaling pathway
pbg04666  Fc gamma R-mediated phagocytosis
pbg04668  TNF signaling pathway
pbg04670  Leukocyte transendothelial migration
pbg04722  Neurotrophin signaling pathway
pbg04725  Cholinergic synapse
pbg04750  Inflammatory mediator regulation of TRP channels
pbg04810  Regulation of actin cytoskeleton
pbg04910  Insulin signaling pathway
pbg04914  Progesterone-mediated oocyte maturation
pbg04915  Estrogen signaling pathway
pbg04917  Prolactin signaling pathway
pbg04919  Thyroid hormone signaling pathway
pbg04923  Regulation of lipolysis in adipocytes
pbg04926  Relaxin signaling pathway
pbg04929  GnRH secretion
pbg04930  Type II diabetes mellitus
pbg04931  Insulin resistance
pbg04932  Non-alcoholic fatty liver disease
pbg04933  AGE-RAGE signaling pathway in diabetic complications
pbg04935  Growth hormone synthesis, secretion and action
pbg04960  Aldosterone-regulated sodium reabsorption
pbg04973  Carbohydrate digestion and absorption
pbg05010  Alzheimer disease
pbg05017  Spinocerebellar ataxia
pbg05020  Prion disease
pbg05100  Bacterial invasion of epithelial cells
pbg05135  Yersinia infection
pbg05142  Chagas disease
pbg05146  Amoebiasis
pbg05160  Hepatitis C
pbg05161  Hepatitis B
pbg05162  Measles
pbg05163  Human cytomegalovirus infection
pbg05164  Influenza A
pbg05165  Human papillomavirus infection
pbg05166  Human T-cell leukemia virus 1 infection
pbg05167  Kaposi sarcoma-associated herpesvirus infection
pbg05168  Herpes simplex virus 1 infection
pbg05169  Epstein-Barr virus infection
pbg05170  Human immunodeficiency virus 1 infection
pbg05171  Coronavirus disease - COVID-19
pbg05200  Pathways in cancer
pbg05203  Viral carcinogenesis
pbg05205  Proteoglycans in cancer
pbg05206  MicroRNAs in cancer
pbg05207  Chemical carcinogenesis - receptor activation
pbg05208  Chemical carcinogenesis - reactive oxygen species
pbg05210  Colorectal cancer
pbg05211  Renal cell carcinoma
pbg05212  Pancreatic cancer
pbg05213  Endometrial cancer
pbg05214  Glioma
pbg05215  Prostate cancer
pbg05218  Melanoma
pbg05220  Chronic myeloid leukemia
pbg05221  Acute myeloid leukemia
pbg05222  Small cell lung cancer
pbg05223  Non-small cell lung cancer
pbg05224  Breast cancer
pbg05225  Hepatocellular carcinoma
pbg05226  Gastric cancer
pbg05230  Central carbon metabolism in cancer
pbg05231  Choline metabolism in cancer
pbg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pbg05415  Diabetic cardiomyopathy
pbg05417  Lipid and atherosclerosis
pbg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122489641 (PIK3R1)
   04014 Ras signaling pathway
    122489641 (PIK3R1)
   04015 Rap1 signaling pathway
    122489641 (PIK3R1)
   04370 VEGF signaling pathway
    122489641 (PIK3R1)
   04630 JAK-STAT signaling pathway
    122489641 (PIK3R1)
   04668 TNF signaling pathway
    122489641 (PIK3R1)
   04066 HIF-1 signaling pathway
    122489641 (PIK3R1)
   04068 FoxO signaling pathway
    122489641 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    122489641 (PIK3R1)
   04072 Phospholipase D signaling pathway
    122489641 (PIK3R1)
   04071 Sphingolipid signaling pathway
    122489641 (PIK3R1)
   04024 cAMP signaling pathway
    122489641 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    122489641 (PIK3R1)
   04152 AMPK signaling pathway
    122489641 (PIK3R1)
   04150 mTOR signaling pathway
    122489641 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122489641 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122489641 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    122489641 (PIK3R1)
   04218 Cellular senescence
    122489641 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122489641 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122489641 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122489641 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122489641 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    122489641 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    122489641 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    122489641 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    122489641 (PIK3R1)
   04660 T cell receptor signaling pathway
    122489641 (PIK3R1)
   04662 B cell receptor signaling pathway
    122489641 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    122489641 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    122489641 (PIK3R1)
   04670 Leukocyte transendothelial migration
    122489641 (PIK3R1)
   04062 Chemokine signaling pathway
    122489641 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122489641 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    122489641 (PIK3R1)
   04929 GnRH secretion
    122489641 (PIK3R1)
   04915 Estrogen signaling pathway
    122489641 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    122489641 (PIK3R1)
   04917 Prolactin signaling pathway
    122489641 (PIK3R1)
   04926 Relaxin signaling pathway
    122489641 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    122489641 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    122489641 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122489641 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122489641 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    122489641 (PIK3R1)
   04722 Neurotrophin signaling pathway
    122489641 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122489641 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    122489641 (PIK3R1)
   04380 Osteoclast differentiation
    122489641 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    122489641 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    122489641 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122489641 (PIK3R1)
   05206 MicroRNAs in cancer
    122489641 (PIK3R1)
   05205 Proteoglycans in cancer
    122489641 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    122489641 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122489641 (PIK3R1)
   05203 Viral carcinogenesis
    122489641 (PIK3R1)
   05230 Central carbon metabolism in cancer
    122489641 (PIK3R1)
   05231 Choline metabolism in cancer
    122489641 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122489641 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122489641 (PIK3R1)
   05212 Pancreatic cancer
    122489641 (PIK3R1)
   05225 Hepatocellular carcinoma
    122489641 (PIK3R1)
   05226 Gastric cancer
    122489641 (PIK3R1)
   05214 Glioma
    122489641 (PIK3R1)
   05221 Acute myeloid leukemia
    122489641 (PIK3R1)
   05220 Chronic myeloid leukemia
    122489641 (PIK3R1)
   05218 Melanoma
    122489641 (PIK3R1)
   05211 Renal cell carcinoma
    122489641 (PIK3R1)
   05215 Prostate cancer
    122489641 (PIK3R1)
   05213 Endometrial cancer
    122489641 (PIK3R1)
   05224 Breast cancer
    122489641 (PIK3R1)
   05222 Small cell lung cancer
    122489641 (PIK3R1)
   05223 Non-small cell lung cancer
    122489641 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122489641 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    122489641 (PIK3R1)
   05161 Hepatitis B
    122489641 (PIK3R1)
   05160 Hepatitis C
    122489641 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    122489641 (PIK3R1)
   05164 Influenza A
    122489641 (PIK3R1)
   05162 Measles
    122489641 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    122489641 (PIK3R1)
   05163 Human cytomegalovirus infection
    122489641 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122489641 (PIK3R1)
   05169 Epstein-Barr virus infection
    122489641 (PIK3R1)
   05165 Human papillomavirus infection
    122489641 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    122489641 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    122489641 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122489641 (PIK3R1)
   05142 Chagas disease
    122489641 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122489641 (PIK3R1)
   05017 Spinocerebellar ataxia
    122489641 (PIK3R1)
   05020 Prion disease
    122489641 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122489641 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    122489641 (PIK3R1)
   05415 Diabetic cardiomyopathy
    122489641 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122489641 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    122489641 (PIK3R1)
   04931 Insulin resistance
    122489641 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122489641 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122489641 (PIK3R1)
   01524 Platinum drug resistance
    122489641 (PIK3R1)
   01522 Endocrine resistance
    122489641 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pbg04131]
    122489641 (PIK3R1)
Membrane trafficking [BR:pbg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122489641 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 CCDC113_CCDC96_CC Laminin_I
Other DBs
NCBI-GeneID: 122489641
NCBI-ProteinID: XP_043447607
LinkDB
Position
A1:135633962..135720990
AA seq 725 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALTLPDLA
EQFAPPDIAPPLLVKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLEMIDV
QVLGDAFKRYLMDLPNPVIPVAVYNEMLYLAQEVQSPEEYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLSQISSKNLLNARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgggcgctgtatgattacaaaaaggaacgagaagaa
gatattgacttgcacttgggcgatgtattgactgtgaataaagggtctttagtagctctt
ggattcagtgacggacaggaagccaggcctgaagaaattggctggttaaatggttataat
gaaaccacgggggaaagaggggactttccaggaacttacgttgaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcaaaagctgaagcagacagtgagcaacaacaagctttgactctgccagatcttgct
gagcagtttgcccctcctgacatcgctccgcctcttcttgtgaagctagtggaagccatt
gaaaagaaaggtctggaatgttcaactttatacagaacacagagctccagcaacccagca
gaattacgacagcttcttgattgtgatgccgcctccgtggacttggaaatgatcgatgtg
caagttttaggagacgctttcaaacgctatcttatggacttaccgaatcctgtcattcca
gtagccgtttacaatgagatgctttatttagcccaagaagtacaaagccctgaagaatat
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggcttacg
cttcagtatttgctaaaacatttcttcaagctctctcaaatctccagcaagaatcttctg
aatgcaagagtactctctgaacttttcagccctctgcttttcagattcccagcagccagc
tctgagaatactgaacacctcataaaagttatagaaattttaatctcgaccgagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccacccaaacccactactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgatgggacctttttggtacgagac
gcatctactaaaatgcacggtgattatactcttacactaaggaaaggaggaaataacaag
ttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactaaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtccctagcccagtataatcccaaa
ctggacgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaa
agtcgagaatatgatagattatatgaagattatacccgtacttcccaggaaatccagatg
aaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagagcagtgccaa
agccaagaacggtacagcaaagaatacatagaaaaatttaaacgggaaggcaatgagaaa
gaaatacaaaggattatgcataattatgaaaagttgaagtctcgcatcagcgaaattgtg
gacagtagaagacgactggaggaggacttgaagaaacaggcagctgagtatcgggagatt
gacaagcgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaacgagtggctgggc
aatgagaacactgaagaccaatactcgctggtggaggatgatgaggatttgccgcaccac
gacgagaagacatggaatgtcggcagcagcaacagaaacaaggctgaaaacctactccgg
gggaagcgagatggcaccttcctggttcgggaaagcagtaaacagggctgctatgcctgc
tcggtagtggtggatggcgaagtgaagcactgtgtcatcaacaaaacggcaactggctac
ggctttgccgagccctataacctgtacagctccctgaaagagctggtgctacattaccaa
cacacctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtatat
gcacagcagaggcgatga

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