KEGG   Prionailurus bengalensis (leopard cat): 122496268
Entry
122496268         CDS       T07574                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg00562  Inositol phosphate metabolism
pbg01100  Metabolic pathways
pbg01521  EGFR tyrosine kinase inhibitor resistance
pbg04012  ErbB signaling pathway
pbg04014  Ras signaling pathway
pbg04015  Rap1 signaling pathway
pbg04020  Calcium signaling pathway
pbg04062  Chemokine signaling pathway
pbg04064  NF-kappa B signaling pathway
pbg04066  HIF-1 signaling pathway
pbg04070  Phosphatidylinositol signaling system
pbg04072  Phospholipase D signaling pathway
pbg04360  Axon guidance
pbg04370  VEGF signaling pathway
pbg04613  Neutrophil extracellular trap formation
pbg04650  Natural killer cell mediated cytotoxicity
pbg04658  Th1 and Th2 cell differentiation
pbg04659  Th17 cell differentiation
pbg04660  T cell receptor signaling pathway
pbg04664  Fc epsilon RI signaling pathway
pbg04666  Fc gamma R-mediated phagocytosis
pbg04670  Leukocyte transendothelial migration
pbg04722  Neurotrophin signaling pathway
pbg04750  Inflammatory mediator regulation of TRP channels
pbg04919  Thyroid hormone signaling pathway
pbg04933  AGE-RAGE signaling pathway in diabetic complications
pbg04935  Growth hormone synthesis, secretion and action
pbg05012  Parkinson disease
pbg05022  Pathways of neurodegeneration - multiple diseases
pbg05135  Yersinia infection
pbg05167  Kaposi sarcoma-associated herpesvirus infection
pbg05170  Human immunodeficiency virus 1 infection
pbg05171  Coronavirus disease - COVID-19
pbg05200  Pathways in cancer
pbg05205  Proteoglycans in cancer
pbg05206  MicroRNAs in cancer
pbg05214  Glioma
pbg05223  Non-small cell lung cancer
pbg05225  Hepatocellular carcinoma
pbg05231  Choline metabolism in cancer
pbg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pbg05417  Lipid and atherosclerosis
Module
pbg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122496268 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122496268 (PLCG1)
   04014 Ras signaling pathway
    122496268 (PLCG1)
   04015 Rap1 signaling pathway
    122496268 (PLCG1)
   04370 VEGF signaling pathway
    122496268 (PLCG1)
   04064 NF-kappa B signaling pathway
    122496268 (PLCG1)
   04066 HIF-1 signaling pathway
    122496268 (PLCG1)
   04020 Calcium signaling pathway
    122496268 (PLCG1)
   04070 Phosphatidylinositol signaling system
    122496268 (PLCG1)
   04072 Phospholipase D signaling pathway
    122496268 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122496268 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    122496268 (PLCG1)
   04660 T cell receptor signaling pathway
    122496268 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    122496268 (PLCG1)
   04659 Th17 cell differentiation
    122496268 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    122496268 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    122496268 (PLCG1)
   04670 Leukocyte transendothelial migration
    122496268 (PLCG1)
   04062 Chemokine signaling pathway
    122496268 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    122496268 (PLCG1)
   04919 Thyroid hormone signaling pathway
    122496268 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    122496268 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122496268 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    122496268 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122496268 (PLCG1)
   05206 MicroRNAs in cancer
    122496268 (PLCG1)
   05205 Proteoglycans in cancer
    122496268 (PLCG1)
   05231 Choline metabolism in cancer
    122496268 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122496268 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    122496268 (PLCG1)
   05214 Glioma
    122496268 (PLCG1)
   05223 Non-small cell lung cancer
    122496268 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122496268 (PLCG1)
   05171 Coronavirus disease - COVID-19
    122496268 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122496268 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    122496268 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    122496268 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    122496268 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122496268 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122496268 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122496268 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pbg04131]
    122496268 (PLCG1)
Enzymes [BR:pbg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122496268 (PLCG1)
Membrane trafficking [BR:pbg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122496268 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122496268 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 122496268
NCBI-ProteinID: XP_043458307
LinkDB
Position
A3:complement(19041215..19077938)
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRTDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
VERPELCRVSLPEFQQFLLEYQGELWATDQLQVQEFMLSFLRDPLREIEEPYFLLDEFVT
FLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVVLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKAGYRAVPLKNNYSEDL
ELASLLIKIEVFPAKQENGDVSPFSSMSLRERGSDASGQLFHGRGREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggaacggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggatcctgctttccga
acagaccagtcacactgctttgtcatactgtatgggatggagttccgcctgaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaaggggttaacttggctg
atggaagatacattgcaggcggccacacctctgcagattgaaaggtggctgaggaagcag
ttctattcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctatgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggcg
gtggagcggccggagctctgtcgcgtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggccaccgaccagcttcaggtgcaagaatttatgctcagcttt
ctccgagaccccttgcgagagattgaagagccgtacttcctcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcagtgtgcccagaa
accatgaacaaccccctctcccactactggatctcctcctcccacaacacatacctgact
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcagacgtcctgcacactatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtccattgaggaccattgcagcattgcc
cagcagaggaacatggcacagtacttcaagaaggtgcttggggacacactccttaccaag
cctgtggacatcgctgccgatggactcccctcacccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggcagagggcagtgcctatgaagaggtgcctacatcagtgatg
tactccgagaacgatatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgagtggtatccccactacttcgtcctgaccagcagcaaaatctactactct
gaggagacgagcagtgaccagggcaacgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccagtgagaaatggttccacgggaagcttggggcaggacgggat
gggcggcacatcgctgagcgcctgcttaccgagtactgcatcgagaccggggcccctgat
ggctccttcctcgtgcgagagagcgagaccttcgtgggcgactataccctctctttctgg
cggaatgggaaagtccagcactgtcggatccactctcggcaggacgctggggcccccaag
ttcttcttgacagacaacctggtctttgactcgctctatgacctcatcacacactaccag
caggtgcccctacgctgcaacgaatttgagatgcgcctctcagagccagtcccgcagacc
aatgcccacgagagcaaagagtggtaccatgccagcctgaccagagctcaggccgagcac
atgctgatgcgcgtcccccgggatggggccttcctggtgaggaaacggaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcattgccgcgtccagcaggag
ggccagacggtggtcctgggcaactcagagttcgacagcctcgtggacctcatcagctac
tatgagaagcacccactgtaccgcaagatgaagctgcgctatcccatcaacgaggaggcg
ctggagaagatcggcacagctgagccagactacggggccctgtatgagggccgcaaccca
ggcttctatgtagaggcgaatcctatgccgactttcaagtgtgcagtcaaagcactcttt
gactacaaggcccagagagaggatgagctgactttcactaagagcgccatcatccagaat
gtggagaagcaagaaggtggctggtggcggggggactatggtgggaagaagcagctgtgg
ttcccgtcaaactacgtggaagagatggtcagccccgcagccctggagcctgagagggag
cacttggacgagaacagccccttgggggatttgctccggggggtcttggatgtgccagct
tgtcagattgccatccgtcccgagggcaagaacaaccggctgttcgtcttctccatcagt
atggcttctgtggcgcactggtccctggatgtcgctgctgactcacaagaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacagcagacgccaggctcacggagggc
aagatgatggagcggaggaagaagatcgccctggagctctctgagctggttgtctactgt
cggcctgttccctttgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtccttcccggaaaccaaggctgagaaatacgtgaacaaggctaaaggcaagaagttt
ctccagtacaaccggctgcagctctcccgcatctaccccaagggccagcggctagactct
tccaattacgaccccttgcccatgtggatctgtggcagtcagctcgtggctctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggccggtggccactgt
ggctacgtgctgcagccgagcaccatgcgggatgaggcctttgatccctttgacaagagc
agcctccgaggcctggagccatatgccatctgcatcgaggtgctgggggcccggcacctg
ccgaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggccggagcagag
tatgacagcatcaaacagaagacagaatttgtggtggacaacggactgaaccctgtttgg
cccgccaagcccttccacttccagatcagtaacccagaattcgccttcctgcgctttgtg
gtgtatgaggaggacatgttcagtgaccagaacttcctggctcaggccaccttcccagtg
aagggcttgaaggcaggatacagagccgtgcctttgaagaacaactacagtgaggacctg
gagctggcctccctgctcatcaagatcgaggttttccctgccaagcaggagaacggtgac
gtcagtcccttcagtagtatgtctctgcgggagcggggctccgatgcctcgggccagctg
ttccatggccggggccgggaaggttcctttgaagcccgctaccagcagccgtttgaggac
tttcgaatctcccaagagcatctggcagaccattttgacagtcgggaacggagggcccca
cgaaggactcgggtcaacggggacaaccgcctctag

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