KEGG   Petaurus breviceps papuanus (sugar glider): 138167502
Entry
138167502         CDS       T10505                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pbrv  Petaurus breviceps papuanus (sugar glider)
Pathway
pbrv01521  EGFR tyrosine kinase inhibitor resistance
pbrv01522  Endocrine resistance
pbrv01524  Platinum drug resistance
pbrv04012  ErbB signaling pathway
pbrv04014  Ras signaling pathway
pbrv04015  Rap1 signaling pathway
pbrv04024  cAMP signaling pathway
pbrv04062  Chemokine signaling pathway
pbrv04066  HIF-1 signaling pathway
pbrv04068  FoxO signaling pathway
pbrv04070  Phosphatidylinositol signaling system
pbrv04071  Sphingolipid signaling pathway
pbrv04072  Phospholipase D signaling pathway
pbrv04081  Hormone signaling
pbrv04140  Autophagy - animal
pbrv04145  Phagocytosis
pbrv04150  mTOR signaling pathway
pbrv04151  PI3K-Akt signaling pathway
pbrv04152  AMPK signaling pathway
pbrv04210  Apoptosis
pbrv04211  Longevity regulating pathway
pbrv04213  Longevity regulating pathway - multiple species
pbrv04218  Cellular senescence
pbrv04360  Axon guidance
pbrv04370  VEGF signaling pathway
pbrv04380  Osteoclast differentiation
pbrv04510  Focal adhesion
pbrv04517  IgSF CAM signaling
pbrv04518  Integrin signaling
pbrv04550  Signaling pathways regulating pluripotency of stem cells
pbrv04611  Platelet activation
pbrv04613  Neutrophil extracellular trap formation
pbrv04620  Toll-like receptor signaling pathway
pbrv04625  C-type lectin receptor signaling pathway
pbrv04630  JAK-STAT signaling pathway
pbrv04650  Natural killer cell mediated cytotoxicity
pbrv04660  T cell receptor signaling pathway
pbrv04662  B cell receptor signaling pathway
pbrv04664  Fc epsilon RI signaling pathway
pbrv04666  Fc gamma R-mediated phagosome formation
pbrv04668  TNF signaling pathway
pbrv04670  Leukocyte transendothelial migration
pbrv04722  Neurotrophin signaling pathway
pbrv04725  Cholinergic synapse
pbrv04750  Inflammatory mediator regulation of TRP channels
pbrv04810  Regulation of actin cytoskeleton
pbrv04910  Insulin signaling pathway
pbrv04914  Progesterone-mediated oocyte maturation
pbrv04915  Estrogen signaling pathway
pbrv04917  Prolactin signaling pathway
pbrv04919  Thyroid hormone signaling pathway
pbrv04923  Regulation of lipolysis in adipocytes
pbrv04926  Relaxin signaling pathway
pbrv04929  GnRH secretion
pbrv04930  Type II diabetes mellitus
pbrv04931  Insulin resistance
pbrv04932  Non-alcoholic fatty liver disease
pbrv04933  AGE-RAGE signaling pathway in diabetic complications
pbrv04935  Growth hormone synthesis, secretion and action
pbrv04960  Aldosterone-regulated sodium reabsorption
pbrv04973  Carbohydrate digestion and absorption
pbrv05010  Alzheimer disease
pbrv05017  Spinocerebellar ataxia
pbrv05020  Prion disease
pbrv05100  Bacterial invasion of epithelial cells
pbrv05135  Yersinia infection
pbrv05142  Chagas disease
pbrv05146  Amoebiasis
pbrv05160  Hepatitis C
pbrv05161  Hepatitis B
pbrv05162  Measles
pbrv05163  Human cytomegalovirus infection
pbrv05164  Influenza A
pbrv05165  Human papillomavirus infection
pbrv05166  Human T-cell leukemia virus 1 infection
pbrv05167  Kaposi sarcoma-associated herpesvirus infection
pbrv05168  Herpes simplex virus 1 infection
pbrv05169  Epstein-Barr virus infection
pbrv05170  Human immunodeficiency virus 1 infection
pbrv05171  Coronavirus disease
pbrv05200  Pathways in cancer
pbrv05203  Viral carcinogenesis
pbrv05205  Proteoglycans in cancer
pbrv05206  MicroRNAs in cancer
pbrv05207  Chemical carcinogenesis - receptor activation
pbrv05208  Chemical carcinogenesis - reactive oxygen species
pbrv05210  Colorectal cancer
pbrv05211  Renal cell carcinoma
pbrv05212  Pancreatic cancer
pbrv05213  Endometrial cancer
pbrv05214  Glioma
pbrv05215  Prostate cancer
pbrv05218  Melanoma
pbrv05220  Chronic myeloid leukemia
pbrv05221  Acute myeloid leukemia
pbrv05222  Small cell lung cancer
pbrv05223  Non-small cell lung cancer
pbrv05224  Breast cancer
pbrv05225  Hepatocellular carcinoma
pbrv05226  Gastric cancer
pbrv05230  Central carbon metabolism in cancer
pbrv05231  Choline metabolism in cancer
pbrv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pbrv05415  Diabetic cardiomyopathy
pbrv05417  Lipid and atherosclerosis
pbrv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pbrv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    138167502 (PIK3R1)
   04014 Ras signaling pathway
    138167502 (PIK3R1)
   04015 Rap1 signaling pathway
    138167502 (PIK3R1)
   04370 VEGF signaling pathway
    138167502 (PIK3R1)
   04630 JAK-STAT signaling pathway
    138167502 (PIK3R1)
   04668 TNF signaling pathway
    138167502 (PIK3R1)
   04066 HIF-1 signaling pathway
    138167502 (PIK3R1)
   04068 FoxO signaling pathway
    138167502 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    138167502 (PIK3R1)
   04072 Phospholipase D signaling pathway
    138167502 (PIK3R1)
   04071 Sphingolipid signaling pathway
    138167502 (PIK3R1)
   04024 cAMP signaling pathway
    138167502 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    138167502 (PIK3R1)
   04152 AMPK signaling pathway
    138167502 (PIK3R1)
   04150 mTOR signaling pathway
    138167502 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    138167502 (PIK3R1)
   04517 IgSF CAM signaling
    138167502 (PIK3R1)
   04518 Integrin signaling
    138167502 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    138167502 (PIK3R1)
   04140 Autophagy - animal
    138167502 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    138167502 (PIK3R1)
   04218 Cellular senescence
    138167502 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138167502 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    138167502 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138167502 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    138167502 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    138167502 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    138167502 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    138167502 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    138167502 (PIK3R1)
   04660 T cell receptor signaling pathway
    138167502 (PIK3R1)
   04662 B cell receptor signaling pathway
    138167502 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    138167502 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    138167502 (PIK3R1)
   04670 Leukocyte transendothelial migration
    138167502 (PIK3R1)
   04062 Chemokine signaling pathway
    138167502 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138167502 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    138167502 (PIK3R1)
   04929 GnRH secretion
    138167502 (PIK3R1)
   04915 Estrogen signaling pathway
    138167502 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    138167502 (PIK3R1)
   04917 Prolactin signaling pathway
    138167502 (PIK3R1)
   04926 Relaxin signaling pathway
    138167502 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    138167502 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    138167502 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    138167502 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    138167502 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    138167502 (PIK3R1)
   04722 Neurotrophin signaling pathway
    138167502 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    138167502 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    138167502 (PIK3R1)
   04380 Osteoclast differentiation
    138167502 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    138167502 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    138167502 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138167502 (PIK3R1)
   05206 MicroRNAs in cancer
    138167502 (PIK3R1)
   05205 Proteoglycans in cancer
    138167502 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    138167502 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    138167502 (PIK3R1)
   05203 Viral carcinogenesis
    138167502 (PIK3R1)
   05230 Central carbon metabolism in cancer
    138167502 (PIK3R1)
   05231 Choline metabolism in cancer
    138167502 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138167502 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138167502 (PIK3R1)
   05212 Pancreatic cancer
    138167502 (PIK3R1)
   05225 Hepatocellular carcinoma
    138167502 (PIK3R1)
   05226 Gastric cancer
    138167502 (PIK3R1)
   05214 Glioma
    138167502 (PIK3R1)
   05221 Acute myeloid leukemia
    138167502 (PIK3R1)
   05220 Chronic myeloid leukemia
    138167502 (PIK3R1)
   05218 Melanoma
    138167502 (PIK3R1)
   05211 Renal cell carcinoma
    138167502 (PIK3R1)
   05215 Prostate cancer
    138167502 (PIK3R1)
   05213 Endometrial cancer
    138167502 (PIK3R1)
   05224 Breast cancer
    138167502 (PIK3R1)
   05222 Small cell lung cancer
    138167502 (PIK3R1)
   05223 Non-small cell lung cancer
    138167502 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138167502 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    138167502 (PIK3R1)
   05161 Hepatitis B
    138167502 (PIK3R1)
   05160 Hepatitis C
    138167502 (PIK3R1)
   05171 Coronavirus disease
    138167502 (PIK3R1)
   05164 Influenza A
    138167502 (PIK3R1)
   05162 Measles
    138167502 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    138167502 (PIK3R1)
   05163 Human cytomegalovirus infection
    138167502 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138167502 (PIK3R1)
   05169 Epstein-Barr virus infection
    138167502 (PIK3R1)
   05165 Human papillomavirus infection
    138167502 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    138167502 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    138167502 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    138167502 (PIK3R1)
   05142 Chagas disease
    138167502 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138167502 (PIK3R1)
   05017 Spinocerebellar ataxia
    138167502 (PIK3R1)
   05020 Prion disease
    138167502 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    138167502 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    138167502 (PIK3R1)
   05415 Diabetic cardiomyopathy
    138167502 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    138167502 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    138167502 (PIK3R1)
   04931 Insulin resistance
    138167502 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    138167502 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138167502 (PIK3R1)
   01524 Platinum drug resistance
    138167502 (PIK3R1)
   01522 Endocrine resistance
    138167502 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pbrv04131]
    138167502 (PIK3R1)
Membrane trafficking [BR:pbrv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    138167502 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 SH3_1 CEP135_TSGA10_CC SH3_2 Laminin_I CCDC113_CCDC96_CC SH3_9 Imm6 ODF2_C Exonuc_VII_L
Other DBs
NCBI-GeneID: 138167502
NCBI-ProteinID: XP_068952547
LinkDB
Position
Unknown
AA seq 731 aa
MVTLAKMSAEGYQYRALYEYKKEREEDIDLHVGDILTVNKGSLVALGFSEGEEAKPDEIG
WLSGFNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKLETDNEQQGFA
LLDLTEQFSSPAIAPPILIKLVEAIEKKGLECPTLYRTQSSSSLAELRQLLDCDASSVDF
DVIDMQVLSDAFKRYLLDLPNPVIPGTIYSEMISVAQELQSTEENVQMLKKLMRTPHIPH
QHGLTLQYLLKHFFRLCQASSKNLLNARSLSEIFSPMLFRSPITGSDNAENLIKTIELLI
SSEWNERQPAPALPPKPPKPTTVTANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADG
TFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESL
AQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRT
SQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKS
RISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKK
LNEWLGNENTEDQYSMVEDDEDLPHHDERTWNVGSSNRSKAENLLRGKRDGTFLVRESSK
QGCFACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVT
LAYPVNAQQRR
NT seq 2196 nt   +upstreamnt  +downstreamnt
atggtaacattggcaaaaatgagtgctgaaggataccaatatagagccttgtatgagtat
aaaaaagaacgggaagaagatattgacttgcatgtgggggatatattaactgtgaataaa
gggtcattagtagcacttggcttcagtgaaggagaagaagcaaagcccgatgaaattggt
tggctaagcggctttaatgaaacaacaggggaaagaggggactttccaggaacttatgta
gaatatattggaaggaaaagaatttcacctcctacaccaaagcctcgtccacctcgaccc
cttcctgtagctccgggctcttcaaaactggaaacagataatgagcaacaaggtttcgca
cttttagacctcacagaacagttttcctctcctgcaattgcgccacctatccttattaaa
ttagtagaagctattgagaagaaaggcctggaatgtccaactttgtacagaacccagagc
tcaagcagcttagctgaactccggcagcttcttgattgtgatgcctcttcagtggacttt
gatgtgattgatatgcaggtcctatctgatgctttcaagagatatctcctggacctgccg
aatcctgtcattccagggacaatttacagtgaaatgatttctgtagcacaagaactacag
agcacagaagagaatgtccagatgctgaagaagcttatgaggactcctcacatacctcat
cagcatgggctcacgcttcagtatttgttaaaacatttcttcagactctgccaagcttca
agcaaaaatcttttgaatgcaagatctctctctgaaattttcagccctatgcttttcagg
tctccaatcacgggctctgataatgccgaaaacctcataaaaacgatagagcttttgatc
tcaagtgaatggaatgagcgacagcctgcaccagcactgcctcctaagccacccaaaccc
actactgtaacagctaacaacggtatgaataacaatatgtccttacaagatgcagagtgg
tactggggagacatctcaagggaagaagtaaatgaaaagctacgtgatacagcagatggt
acctttttggttcgagatgcatccaccaaaatgcatggtgactatactcttacacttagg
aaaggaggaaataacaaattaatcaaaatatttcaccgagatgggaaatatggcttctct
gacccattgactttcaattctgtggttgaactgataaaccactaccggaatgaatctcta
gctcagtataatcccaaactggatgtgaaattactttatccagtatccaagtaccaacag
gatcaagtagtaaaagaagataatattgaagctgtaggaaagaagttacatgaatataac
actcaattccaagaaaaaagcagagaatatgatcgattatatgaagattatacccgtaca
tctcaggaaatccaaatgaaaagaacagctatcgaagcatttaatgaaacaataaagata
tttgaagaacagtgccaaacccaggaacggtacagcaaagaatacatagaaaagtttaaa
cgtgaaggaaatgaaaaagaaatacaaaggattatgcataattatgaaaagttaaagtct
cgaatcagtgaaattgtggatagtagacgaaggttagaggaggatttgaagaagcaagct
gctgagtatcgagagattgacaaacggatgaacagcattaagccagatctcattcaactg
aggaagacaagggaccaatacttaatgtggttgactcaaaaaggtgtccgacaaaagaag
ttgaatgaatggctgggcaatgaaaatacagaagaccaatattcaatggtggaagatgac
gaggacttgccgcaccatgatgagaggacgtggaatgtgggcagcagcaaccggagcaag
gcagagaacctcttgcgtggcaaaagggacggcaccttcctggtccgagagagcagcaag
cagggctgttttgcttgctccgtagtggtggatggtgaagtaaagcactgcgtgataaac
aaaacgccaacggggtatggatttgcagagccatataacttgtacaactctctgaaagag
ctggtgctacattaccaacacacatcccttgttcagcacaacgactctctcaatgtcacc
ttagcctacccagtcaatgcacagcagaggcgatga

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