Physeter macrocephalus (sperm whale): 102988082 Help Entry 102988082         CDS       T06011                                  Symbol CASP8 Name (RefSeq) caspase-8 isoform X1   KO K04398   caspase 8 [EC:3.4.22.61] Organism pcad  Physeter macrocephalus (sperm whale) Pathway pcad01524   Platinum drug resistance pcad04115   p53 signaling pathway pcad04210   Apoptosis pcad04215   Apoptosis - multiple species pcad04217   Necroptosis pcad04620   Toll-like receptor signaling pathway pcad04621   NOD-like receptor signaling pathway pcad04622   RIG-I-like receptor signaling pathway pcad04623   Cytosolic DNA-sensing pathway pcad04625   C-type lectin receptor signaling pathway pcad04657   IL-17 signaling pathway pcad04668   TNF signaling pathway pcad04932   Non-alcoholic fatty liver disease pcad04936   Alcoholic liver disease pcad05010   Alzheimer disease pcad05016   Huntington disease pcad05022   Pathways of neurodegeneration - multiple diseases pcad05132   Salmonella infection pcad05134   Legionellosis pcad05142   Chagas disease pcad05145   Toxoplasmosis pcad05152   Tuberculosis pcad05160   Hepatitis C pcad05161   Hepatitis B pcad05162   Measles pcad05163   Human cytomegalovirus infection pcad05164   Influenza A pcad05165   Human papillomavirus infection pcad05167   Kaposi sarcoma-associated herpesvirus infection pcad05168   Herpes simplex virus 1 infection pcad05169   Epstein-Barr virus infection pcad05170   Human immunodeficiency virus 1 infection pcad05200   Pathways in cancer pcad05203   Viral carcinogenesis pcad05416   Viral myocarditis pcad05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     102988082 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     102988082 (CASP8)    04215 Apoptosis - multiple species     102988082 (CASP8)    04217 Necroptosis     102988082 (CASP8)    04115 p53 signaling pathway     102988082 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102988082 (CASP8)    04621 NOD-like receptor signaling pathway     102988082 (CASP8)    04622 RIG-I-like receptor signaling pathway     102988082 (CASP8)    04623 Cytosolic DNA-sensing pathway     102988082 (CASP8)    04625 C-type lectin receptor signaling pathway     102988082 (CASP8)    04657 IL-17 signaling pathway     102988082 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102988082 (CASP8)    05203 Viral carcinogenesis     102988082 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102988082 (CASP8)    05161 Hepatitis B     102988082 (CASP8)    05160 Hepatitis C     102988082 (CASP8)    05164 Influenza A     102988082 (CASP8)    05162 Measles     102988082 (CASP8)    05168 Herpes simplex virus 1 infection     102988082 (CASP8)    05163 Human cytomegalovirus infection     102988082 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     102988082 (CASP8)    05169 Epstein-Barr virus infection     102988082 (CASP8)    05165 Human papillomavirus infection     102988082 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     102988082 (CASP8)    05134 Legionellosis     102988082 (CASP8)    05152 Tuberculosis     102988082 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102988082 (CASP8)    05142 Chagas disease     102988082 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     102988082 (CASP8)    05016 Huntington disease     102988082 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     102988082 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102988082 (CASP8)    05416 Viral myocarditis     102988082 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     102988082 (CASP8)    04932 Non-alcoholic fatty liver disease     102988082 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     102988082 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:pcad01002]     102988082 (CASP8) Enzymes [BR:pcad01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      102988082 (CASP8) Peptidases and inhibitors [BR:pcad01002]  Cysteine peptidases   Family C14: caspase family    102988082 (CASP8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C14 DED Dynamin_N ARM_TT21_5th Motif Other DBs NCBI-GeneID:  102988082 NCBI-ProteinID:  XP_007112978 Ensembl:  ENSPCTG00005001931 UniProt:  A0A2Y9F1C7 LinkDB All DBs Position 2:105034782..105085748 Genome browser AA seq 486 aa AA seqDB search MNFNRCLYNIGEQLGSEDLAALKFLSLDYIPHRKQEPIKDALMLFQRLQEKRMLEESNLS FLKELLFRMNRLDLLLTYLDTSEEEMERELQMPGRAQISAYRVMLFQISEDVNKLELKDF KFFLSQEIAKCKLDDDMTLLDIFIEMEKRVILGERNLDTLKRICEQINRSLLKKINDYEE LSREQRMSLERGPDEFSNDVSQLLMREGSLEMLAMSDSPGEKDSESQTSNTVYRMKSKPR GYCLIFNNYDFSIARKDVPKLHSIKDRNGTDLDAEALRKTFSELHFEIVHYKDYTAKKIC EVLKSYQSMDHNNKDCFICCILSHGDKGIIYGSDGQEAPIYELTSYFTGSKCPSLLGKPK IFFIQACQGDNYQRGIAVEADSEQKEAYLEMDSSLQKRYIPDEADFLLGMATVNNCVSYR STMEGTWYIQSLCQSLRERCPRGEDILTILTKVNFEVSNKDDKKNMGKQMPQPTFTLRKK LFFPLN NT seq 1461 nt NT seq  +upstreamnt  +downstreamnt atgaatttcaacagatgtctctataatattggggaacagctgggcagtgaagacctggct gccctcaagttcctgagcctggactacattccacataggaagcaggaacccatcaaggat gccttgatgctattccagaggctccaagaaaagagaatgttggaggaaagcaacctgtcc ttcttgaaggagctgcttttccgaatgaatagactggatctgctgctcacctacctggac accagtgaggaggagatggagagggagcttcagatgccgggcagggcccagatctctgcc tatagggtcatgctttttcagatttcagaagatgtgaacaaactggaattgaaggacttc aagttttttttgagccaggagatcgccaaatgtaagctggatgatgacatgaccttgctt gatattttcatagagatggagaagagggtcatcctaggggaaagaaacttggacaccctg aaaagaatctgtgagcaaatcaacaggagcctcctgaagaaaatcaatgattatgaagaa ctaagcagagagcaaagaatgagccttgaaagaggtccggatgaattttcaaacgatgtt tcacaattgctcatgagggagggctctcttgaaatgctggccatgtcggactctccagga gaaaaggacagtgagtcacagacatcgaacacagtttaccgaatgaaaagcaaacctcgg ggatactgtttgatctttaacaattatgattttagcatagcaaggaaggatgtgcccaaa cttcacagcattaaggataggaatggaacagacttggatgcagaggctttgagaaagacc tttagcgagcttcattttgagatagtgcattacaaagactacactgcgaagaaaatctgt gaggttctgaaatcctaccaaagcatggaccacaataacaaggactgcttcatctgctgc atcctctcccatggagacaaaggcatcatctatggctccgatgggcaggaagcccccatc tatgagctgacctcttacttcactggttcaaagtgcccttcccttcttggcaaacccaaa atcttttttattcaggcttgtcaaggggataactaccagagaggtatagctgttgaggct gactcagaacagaaggaagcctatttagaaatggattcatcacttcagaagagatatatc ccagatgaggctgactttctgctggggatggccaccgtgaacaactgtgtttcctaccga agcaccatggaggggacctggtatatccagtcactttgccagagcctgagagaaagatgt cctaggggtgaagatattctcaccatcctcaccaaggtgaactttgaagtaagcaataag gatgacaagaaaaatatgggcaaacagatgccacaacctactttcacactgagaaaaaaa ctcttctttccccttaattga

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