Physeter macrocephalus (sperm whale): 102992290 Help Entry 102992290         CDS       T06011                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism pcad  Physeter macrocephalus (sperm whale) Pathway pcad04022   cGMP-PKG signaling pathway pcad04068   FoxO signaling pathway pcad04081   Hormone signaling pcad04140   Autophagy - animal pcad04150   mTOR signaling pathway pcad04151   PI3K-Akt signaling pathway pcad04152   AMPK signaling pathway pcad04211   Longevity regulating pathway pcad04213   Longevity regulating pathway - multiple species pcad04722   Neurotrophin signaling pathway pcad04910   Insulin signaling pathway pcad04920   Adipocytokine signaling pathway pcad04923   Regulation of lipolysis in adipocytes pcad04930   Type II diabetes mellitus pcad04931   Insulin resistance pcad04932   Non-alcoholic fatty liver disease pcad04935   Growth hormone synthesis, secretion and action pcad04960   Aldosterone-regulated sodium reabsorption pcad05010   Alzheimer disease pcad05206   MicroRNAs in cancer pcad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     102992290 (IRS1)    04022 cGMP-PKG signaling pathway     102992290 (IRS1)    04151 PI3K-Akt signaling pathway     102992290 (IRS1)    04152 AMPK signaling pathway     102992290 (IRS1)    04150 mTOR signaling pathway     102992290 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     102992290 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102992290 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102992290 (IRS1)    04923 Regulation of lipolysis in adipocytes     102992290 (IRS1)    04920 Adipocytokine signaling pathway     102992290 (IRS1)    04935 Growth hormone synthesis, secretion and action     102992290 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102992290 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102992290 (IRS1)   09149 Aging    04211 Longevity regulating pathway     102992290 (IRS1)    04213 Longevity regulating pathway - multiple species     102992290 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     102992290 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     102992290 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102992290 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102992290 (IRS1)    04932 Non-alcoholic fatty liver disease     102992290 (IRS1)    04931 Insulin resistance     102992290 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  102992290 NCBI-ProteinID:  XP_007127060 Ensembl:  ENSPCTG00005011909 UniProt:  A0A2Y9FMQ1 LinkDB All DBs Position 2:complement(127316689..127388222) Genome browser AA seq 1245 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGASCSGSSGLGEAGEDLSYGDAPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRSGNGHRYIPAAGLGTSPALTGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGTGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRVGHHR PDTSNLHTDDGYMPMSPGVAPVPGSRKGSADYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSGGSSSGVAPSGSSYGKLWTNGVGGHHSHALPHPRLPVES SSGKLLSCTGGYMNMSPVGDSNTSSPSDCYCGPEDPQHKPVLSYYSLPRSFKHTQRPGEL EEGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGFCAARPEPGLPHLHHQVLQPH LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQPPPPPPPLLPPPEPKSPGEYVN IEFGSDQPGYLSGPGASHSSPSVRCPSQLQPAPREEETGAEEYMNMDLGPGRRAAWRESP GVQPGSMGPAPAGAASVCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRAG GGVVVEEASLLGAAAAAPSSSSTASASPAGPQAAEELTARPSLLGGPQGPGGPSAFTRVN LSPNRNPSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVPFGGGAAAGGGGGGSSTED VKRHSSASFENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFNQSPQERPA QPQPPPPPPPHQSLGRSESGSTSRSSEDLSAYASISFQKPPEDLQ NT seq 3738 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctcccgagaccgacggcttctccgacgtgcgcaaggtgggctacctgcgc aagcccaagagcatgcacaagcgattcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggccgactccaagaac aagcacctggtggccctctatacccgggacgagcactttgccatcgcggcggacagtgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcccccggagcgggaggcggcggggccagctgcagtggcagctcc ggccttggcgaggctggggaggacttgagctacggggacgcgcccccaggacccgccttc aaggaagtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gctgccgcggtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacgggacccggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacaatcctggaagccatgcgggccatg agcgatgagttccgccctcgaagcaagagccagtcctcctccaactgctccaaccccatc agtgtccccctgcgcaggcatcacctcaacaaccctccacccagccaggtggggctgacc cgccgctcgcgcacagagagcatcactgccacctccccggccagcttggtgggcgggaag cagggctccttccgggtccgtgcgtctagtgatggcgaaggcaccatgtctcgccctgcc tctgtggacggcagtcctgtgagtcccagcaccaacaggacccatgcccaccggcatcga ggcagttcccggctgcacccgcctctcaaccacagccgctccatccccatgccatcttct cgctgctcgccttccgccaccagcccggtcagtctgtcgtccagtagcaccagtggccac ggctccacctcggactgtctcttcccgcggcggtctagtgcttccgtgtctggttccccc agtgatggcggtttcatctcctctgatgagtatggctccagtccctgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacaccccgccggcccgcggtgaggag gagctgagcaactacatctgcatgggaggcaagggggcctccaccctcacggcccccaat ggtcactacattttgcctcggagtggcaacggtcaccgctacatcccggcagctggcttg ggcacgagcccagccctgacaggggatgaagcagccagtgctgcagatctggacaatcgg ttccgaaagcggactcactctgctggcacgtcgcctaccatttcccaccagaagacccca tcccagtcctctgtggcctccattgaggagtataccgagatgatgcctgcctacccacca ggaggtggcactggaggccgagtgcccagctaccgccactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgtgggccaccaccgc ccagacacctccaacctccacaccgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccgggagccgaaagggcagtgcggactacatgcccatgagccccaagagcgtg tctgcccctcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggcgggcccagc agcggcggcagcagcagcggtgtcgccccttctgggagcagctatggcaagctctggacg aatggggtagggggccaccactctcacgccctgccacaccccagactccctgtggagagc agtagcggcaagctgttgtcttgtacgggtggctacatgaacatgtcgccagtgggggac tccaacaccagcagcccttccgactgctactgtggccccgaggacccccagcacaagcca gtcctctcctactactcactgccaaggtcctttaagcacacccagcgccccggggagctg gaggagggcgcccggcaccagcacctccgcctttcctccagctccggtcgactcctctat gctgcggcggcggaagattcctcctcgtccaccagcagcgacagcctgggggggggattc tgcgcggctaggcccgagcccggcctcccgcatctccaccatcaggtcctgcagccccat ctgcctcgaaaggtggacacagctgcccagaccaacagccgcctggcccggcccacgagg ctgtccctgggggatcccaaggccagcaccttaccccgggcccgagagcagcagccgccg ccgccgccgccgcccctgctgccccctccggagcccaagagcccaggggaatatgtgaat attgaatttgggagcgatcagccgggctacttatcaggcccgggggcgtcccacagctcg ccttctgtccggtgtccatcccagctccagcccgctcccagagaggaggagacgggcgcg gaagagtacatgaacatggacctggggccgggccggagggccgcctggcgggagagccct ggggtccagccgggcagcatgggcccggcgcccgctggagccgctagcgtgtgcaggccc accagggcagtgcccagcagccggggtgactacatgaccatgcagatgggctgtccccgg cagagctacgtggacacctcgccggtcgcccccatcagctatgcggacatgcgggccggc ggcggcgtcgtcgtggaggaggccagcctgcttggggccgccgcggccgcgccctcctct tcctcgacggcctctgcttcccccgctgggcctcaagcagcagaggaactgacggcccgc ccttccctgctggggggcccgcagggacccgggggcccgagtgccttcacgcgggtgaac ctcagtcccaaccgcaacccgagtgccaaagtgatccgtgccgacccgcaagggtgcagg aggaggcacagctccgagaccttctcctcgacgcccagcgccacccgggcaggcaacacg gtgcccttcggagggggggctgcagccgggggcggcggcggcggcagcagcacggaggat gtgaaacgccacagctctgcttcctttgagaacgtgtggctgcggcctggggagctcggg ggagcccccaaggagctggcccaagtgtgcggggccgccgggggtctggagaatgggctt aactacatagacctggatttggtcaaggacttcaaccagagccctcaagagcgccccgct cagccgcagcctcctcctcccccgccccctcatcagtctctgggacgcagcgagagcggc tccaccagccgctccagcgaggatttaagcgcctatgccagcatcagtttccagaagccg ccagaggacctccagtag

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