Puma concolor (puma): 112853630 Help Entry 112853630         CDS       T08890                                  Symbol TNF Name (RefSeq) tumor necrosis factor   KO K03156   tumor necrosis factor superfamily, member 2 Organism pcoo  Puma concolor (puma) Pathway pcoo01523   Antifolate resistance pcoo04010   MAPK signaling pathway pcoo04060   Cytokine-cytokine receptor interaction pcoo04061   Viral protein interaction with cytokine and cytokine receptor pcoo04064   NF-kappa B signaling pathway pcoo04071   Sphingolipid signaling pathway pcoo04150   mTOR signaling pathway pcoo04210   Apoptosis pcoo04217   Necroptosis pcoo04350   TGF-beta signaling pathway pcoo04380   Osteoclast differentiation pcoo04612   Antigen processing and presentation pcoo04620   Toll-like receptor signaling pathway pcoo04621   NOD-like receptor signaling pathway pcoo04622   RIG-I-like receptor signaling pathway pcoo04625   C-type lectin receptor signaling pathway pcoo04640   Hematopoietic cell lineage pcoo04650   Natural killer cell mediated cytotoxicity pcoo04657   IL-17 signaling pathway pcoo04660   T cell receptor signaling pathway pcoo04664   Fc epsilon RI signaling pathway pcoo04668   TNF signaling pathway pcoo04920   Adipocytokine signaling pathway pcoo04930   Type II diabetes mellitus pcoo04931   Insulin resistance pcoo04932   Non-alcoholic fatty liver disease pcoo04933   AGE-RAGE signaling pathway in diabetic complications pcoo04936   Alcoholic liver disease pcoo04940   Type I diabetes mellitus pcoo05010   Alzheimer disease pcoo05014   Amyotrophic lateral sclerosis pcoo05020   Prion disease pcoo05022   Pathways of neurodegeneration - multiple diseases pcoo05132   Salmonella infection pcoo05133   Pertussis pcoo05134   Legionellosis pcoo05135   Yersinia infection pcoo05140   Leishmaniasis pcoo05142   Chagas disease pcoo05143   African trypanosomiasis pcoo05144   Malaria pcoo05145   Toxoplasmosis pcoo05146   Amoebiasis pcoo05152   Tuberculosis pcoo05160   Hepatitis C pcoo05161   Hepatitis B pcoo05163   Human cytomegalovirus infection pcoo05164   Influenza A pcoo05165   Human papillomavirus infection pcoo05166   Human T-cell leukemia virus 1 infection pcoo05168   Herpes simplex virus 1 infection pcoo05169   Epstein-Barr virus infection pcoo05170   Human immunodeficiency virus 1 infection pcoo05171   Coronavirus disease - COVID-19 pcoo05205   Proteoglycans in cancer pcoo05310   Asthma pcoo05321   Inflammatory bowel disease pcoo05322   Systemic lupus erythematosus pcoo05323   Rheumatoid arthritis pcoo05330   Allograft rejection pcoo05332   Graft-versus-host disease pcoo05410   Hypertrophic cardiomyopathy pcoo05414   Dilated cardiomyopathy pcoo05417   Lipid and atherosclerosis pcoo05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     112853630 (TNF)    04350 TGF-beta signaling pathway     112853630 (TNF)    04064 NF-kappa B signaling pathway     112853630 (TNF)    04668 TNF signaling pathway     112853630 (TNF)    04071 Sphingolipid signaling pathway     112853630 (TNF)    04150 mTOR signaling pathway     112853630 (TNF)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     112853630 (TNF)    04061 Viral protein interaction with cytokine and cytokine receptor     112853630 (TNF)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     112853630 (TNF)    04217 Necroptosis     112853630 (TNF)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     112853630 (TNF)    04620 Toll-like receptor signaling pathway     112853630 (TNF)    04621 NOD-like receptor signaling pathway     112853630 (TNF)    04622 RIG-I-like receptor signaling pathway     112853630 (TNF)    04625 C-type lectin receptor signaling pathway     112853630 (TNF)    04650 Natural killer cell mediated cytotoxicity     112853630 (TNF)    04612 Antigen processing and presentation     112853630 (TNF)    04660 T cell receptor signaling pathway     112853630 (TNF)    04657 IL-17 signaling pathway     112853630 (TNF)    04664 Fc epsilon RI signaling pathway     112853630 (TNF)   09152 Endocrine system    04920 Adipocytokine signaling pathway     112853630 (TNF)   09158 Development and regeneration    04380 Osteoclast differentiation     112853630 (TNF)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     112853630 (TNF)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112853630 (TNF)    05170 Human immunodeficiency virus 1 infection     112853630 (TNF)    05161 Hepatitis B     112853630 (TNF)    05160 Hepatitis C     112853630 (TNF)    05171 Coronavirus disease - COVID-19     112853630 (TNF)    05164 Influenza A     112853630 (TNF)    05168 Herpes simplex virus 1 infection     112853630 (TNF)    05163 Human cytomegalovirus infection     112853630 (TNF)    05169 Epstein-Barr virus infection     112853630 (TNF)    05165 Human papillomavirus infection     112853630 (TNF)   09171 Infectious disease: bacterial    05132 Salmonella infection     112853630 (TNF)    05135 Yersinia infection     112853630 (TNF)    05133 Pertussis     112853630 (TNF)    05134 Legionellosis     112853630 (TNF)    05152 Tuberculosis     112853630 (TNF)   09174 Infectious disease: parasitic    05146 Amoebiasis     112853630 (TNF)    05144 Malaria     112853630 (TNF)    05145 Toxoplasmosis     112853630 (TNF)    05140 Leishmaniasis     112853630 (TNF)    05142 Chagas disease     112853630 (TNF)    05143 African trypanosomiasis     112853630 (TNF)   09163 Immune disease    05310 Asthma     112853630 (TNF)    05322 Systemic lupus erythematosus     112853630 (TNF)    05323 Rheumatoid arthritis     112853630 (TNF)    05321 Inflammatory bowel disease     112853630 (TNF)    05330 Allograft rejection     112853630 (TNF)    05332 Graft-versus-host disease     112853630 (TNF)   09164 Neurodegenerative disease    05010 Alzheimer disease     112853630 (TNF)    05014 Amyotrophic lateral sclerosis     112853630 (TNF)    05020 Prion disease     112853630 (TNF)    05022 Pathways of neurodegeneration - multiple diseases     112853630 (TNF)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     112853630 (TNF)    05418 Fluid shear stress and atherosclerosis     112853630 (TNF)    05410 Hypertrophic cardiomyopathy     112853630 (TNF)    05414 Dilated cardiomyopathy     112853630 (TNF)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     112853630 (TNF)    04940 Type I diabetes mellitus     112853630 (TNF)    04936 Alcoholic liver disease     112853630 (TNF)    04932 Non-alcoholic fatty liver disease     112853630 (TNF)    04931 Insulin resistance     112853630 (TNF)    04933 AGE-RAGE signaling pathway in diabetic complications     112853630 (TNF)   09176 Drug resistance: antineoplastic    01523 Antifolate resistance     112853630 (TNF)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:pcoo04052]     112853630 (TNF)    00536 Glycosaminoglycan binding proteins [BR:pcoo00536]     112853630 (TNF) Cytokines and neuropeptides [BR:pcoo04052]  Cytokines   Tumor necrosis fators    112853630 (TNF) Glycosaminoglycan binding proteins [BR:pcoo00536]  Heparan sulfate / Heparin   Cytokines    112853630 (TNF) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TNF Motif Other DBs NCBI-GeneID:  112853630 NCBI-ProteinID:  XP_025772972 UniProt:  A0A6P6HB69 LinkDB All DBs Position Unknown AA seq 233 aa AA seqDB search MSTESMIRDVELAEEALPKKAGGPQGSRRCLCLSLFSFLLVAGATTLFCLLHFGVIGPQR EELPHGLQLINPLPQTLRSSSRTPSDKPVAHVVANPEAEGQLQWLSRRANALLANGVELT DNQLKVPSDGLYLIYSQVLFTGQGCPSTHVLLTHTISRFAVSYQTKVNLLSAIKSPCQRE TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINLPDYLDFAESGQVYFGIIAL NT seq 702 nt NT seq  +upstreamnt  +downstreamnt atgagcactgaaagcatgatccgggacgtggagctggccgaggaggcactccccaagaag gcagggggcccccagggctccagaaggtgcttgtgcctcagcctcttctccttcctcctc gtcgcaggagccaccacactcttctgcctgctgcactttggagtgatcggcccccagagg gaagagctcccacatggcctgcaactaatcaaccctctgccccagacactcagatcatct tctcgaactccgagtgacaagccagtagcccatgtagtagcaaaccccgaagctgaaggg caactccagtggctgagccggcgtgccaatgccctcctggccaatggcgtggagctgaca gacaaccagctgaaggtgccctcagacgggctgtacctcatctactcccaggtcctcttc acgggccaaggatgtccttccacacatgtgctcctcacccacaccatcagccgctttgcc gtttcctaccagaccaaggtcaacctcctctctgccatcaagagcccttgccagagggag accccagagggggctgaggccaagccctggtatgagcccatctacctgggaggggtcttc caactggagaagggtgatcgactcagcgctgagatcaatctgcctgactatcttgacttt gccgagtctgggcaagtctactttggaatcattgccctgtga

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